{"id":{"repo_id":"uiuc","oai_identifier":"oai:www.ideals.illinois.edu:2142/82543"},"canonical_url":"https://search.dev.ndltd.org/etd/uiuc/oai:www.ideals.illinois.edu:2142/82543","repository":{"repo_id":"uiuc","name":"University of Illinois - Urbana-Champaign","base_url":"https://www.ideals.illinois.edu/oai-pmh"},"display":{"title":"Elucidating the Role of the Fragile-X Mental Retardation Protein in the Central Nervous System","abstract":"The discovery that proteins are synthesized at synapses, away from somata where most proteins are made, is fairly recent, and only a couple of proteins are currently known to be made near synapses; none have been shown to be made in response to changes in the synaptic environment. Proteins made in response to afferent activity at synapses are likely candidates to be involved with the plasticity (functional, structural, or both) of synapses, as afferent activation is largely responsible for the postnatal organization of the nervous system. In attempts to discern which proteins are made at synapses specifically for involvement in synaptic plasticity, it was discovered that fmr -1 mRNA, a product of the FMR-1 gene, associates rapidly with protein synthesis machinery in response to neurotransmitter stimulation in an in vitro synaptoneurosome preparation. This suggested that the Fragile-X Mental Retardation Protein, the product of fmr-1 mRNA, is synthesized at synapses in response to afferent activation and is possibly involved in synaptic plasticity. The following studies attempt to further link the expression/function of this protein with synaptic plasticity processes.","abstract_html":"The discovery that proteins are synthesized at synapses, away from somata where most proteins are made, is fairly recent, and only a couple of proteins are currently known to be made near synapses; none have been shown to be made in response to changes in the synaptic environment. Proteins made in response to afferent activity at synapses are likely candidates to be involved with the plasticity (functional, structural, or both) of synapses, as afferent activation is largely responsible for the postnatal organization of the nervous system. In attempts to discern which proteins are made at synapses specifically for involvement in synaptic plasticity, it was discovered that fmr -1 mRNA, a product of the FMR-1 gene, associates rapidly with protein synthesis machinery in response to neurotransmitter stimulation in an in vitro synaptoneurosome preparation. This suggested that the Fragile-X Mental Retardation Protein, the product of fmr-1 mRNA, is synthesized at synapses in response to afferent activation and is possibly involved in synaptic plasticity. The following studies attempt to further link the expression/function of this protein with synaptic plasticity processes.","abstract_has_math":false,"creators":["Irwin, Scott Alan"],"institution":"University of Illinois at Urbana-Champaign","degree_name":"Ph.D.","degree_level":"Dissertation","degree_discipline":"Neuroscience","degree_department":null,"school":null,"contributors":["Greenough, William T."],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2015,"date_issued":"2015-09-25T20:45:47Z","date_published":"2015-09-25T20:45:47Z","updated_at":"2026-07-22T22:26:18Z","subjects":["Health Sciences, Human Development"],"languages":["eng"],"rights":[],"rights_urls":[],"identifier_entries":[{"key":"dc:identifier","label":"Identifier","values":["(MiAaPQ)AAI9971102"],"render_values":[{"text":"(MiAaPQ)AAI9971102","href":null,"code":true}]}]},"links":{"outbound_url":"http://hdl.handle.net/2142/82543","outbound_label":"Handle","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["Greenough, William T."]},{"key":"dc:creator","label":"Author","values":["Irwin, Scott Alan"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["2015-09-25T20:45:47Z","10000-01-01","2000"]},{"key":"dc:type","label":"Dc Type","values":["text"]},{"key":"thesis:degree_discipline","label":"Discipline","values":["Neuroscience"]},{"key":"thesis:degree_level","label":"Degree Level","values":["Dissertation"]},{"key":"thesis:degree_name","label":"Degree Name","values":["Ph.D."]},{"key":"thesis:institution_name","label":"Thesis Institution Name","values":["University of Illinois at Urbana-Champaign"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Health Sciences, Human Development"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["eng"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["http://hdl.handle.net/2142/82543","(MiAaPQ)AAI9971102"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["The discovery that proteins are synthesized at synapses, away from somata where most proteins are made, is fairly recent, and only a couple of proteins are currently known to be made near synapses; none have been shown to be made in response to changes in the synaptic environment. Proteins made in response to afferent activity at synapses are likely candidates to be involved with the plasticity (functional, structural, or both) of synapses, as afferent activation is largely responsible for the postnatal organization of the nervous system. In attempts to discern which proteins are made at synapses specifically for involvement in synaptic plasticity, it was discovered that fmr -1 mRNA, a product of the FMR-1 gene, associates rapidly with protein synthesis machinery in response to neurotransmitter stimulation in an in vitro synaptoneurosome preparation. This suggested that the Fragile-X Mental Retardation Protein, the product of fmr-1 mRNA, is synthesized at synapses in response to afferent activation and is possibly involved in synaptic plasticity. The following studies attempt to further link the expression/function of this protein with synaptic plasticity processes.","Made available in DSpace on 2015-09-25T20:45:47Z (GMT). No. of bitstreams: 2 license.txt: 4848 bytes, checksum: 96035ab3f5e1c23cc7138a224ce498bd (MD5) 9971102.pdf: 7655242 bytes, checksum: df9577235ee05e8098ede8b94798e04b (MD5) Previous issue date: 2000","Embargo set by: Seth Robbins for item 83824 Lift date: Forever Reason: Restricted to the U of I community idenfinitely during batch ingest of legacy ETDs","Restricted to the U of I community idenfinitely during batch ingest of legacy ETDs","U of I Only","156 p.","Thesis (Ph.D.)--University of Illinois at Urbana-Champaign, 2000."]},{"key":"dc:title","label":"Title","values":["Elucidating the Role of the Fragile-X Mental Retardation Protein in the Central Nervous System"]}]}],"canonical_facts":{"dc:contributor":["Greenough, William T."],"dc:creator":["Irwin, Scott Alan"],"dc:date":["2015-09-25T20:45:47Z","10000-01-01","2000"],"dc:description":["The discovery that proteins are synthesized at synapses, away from somata where most proteins are made, is fairly recent, and only a couple of proteins are currently known to be made near synapses; none have been shown to be made in response to changes in the synaptic environment. Proteins made in response to afferent activity at synapses are likely candidates to be involved with the plasticity (functional, structural, or both) of synapses, as afferent activation is largely responsible for the postnatal organization of the nervous system. In attempts to discern which proteins are made at synapses specifically for involvement in synaptic plasticity, it was discovered that fmr -1 mRNA, a product of the FMR-1 gene, associates rapidly with protein synthesis machinery in response to neurotransmitter stimulation in an in vitro synaptoneurosome preparation. This suggested that the Fragile-X Mental Retardation Protein, the product of fmr-1 mRNA, is synthesized at synapses in response to afferent activation and is possibly involved in synaptic plasticity. The following studies attempt to further link the expression/function of this protein with synaptic plasticity processes.","Made available in DSpace on 2015-09-25T20:45:47Z (GMT). No. of bitstreams: 2 license.txt: 4848 bytes, checksum: 96035ab3f5e1c23cc7138a224ce498bd (MD5) 9971102.pdf: 7655242 bytes, checksum: df9577235ee05e8098ede8b94798e04b (MD5) Previous issue date: 2000","Embargo set by: Seth Robbins for item 83824 Lift date: Forever Reason: Restricted to the U of I community idenfinitely during batch ingest of legacy ETDs","Restricted to the U of I community idenfinitely during batch ingest of legacy ETDs","U of I Only","156 p.","Thesis (Ph.D.)--University of Illinois at Urbana-Champaign, 2000."],"dc:identifier":["http://hdl.handle.net/2142/82543","(MiAaPQ)AAI9971102"],"dc:language":["eng"],"dc:subject":["Health Sciences, Human Development"],"dc:title":["Elucidating the Role of the Fragile-X Mental Retardation Protein in the Central Nervous System"],"dc:type":["text"],"thesis:degree_discipline":["Neuroscience"],"thesis:degree_level":["Dissertation"],"thesis:degree_name":["Ph.D."],"thesis:institution_name":["University of Illinois at Urbana-Champaign"]},"updated_at":"2026-07-22T22:26:18Z"}