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We attempt to mix sections of the sample solution where the analyte concentration is high with other sections where it is low, and thereby reduce the sensor response time when the detection kinetics are diffusion-limited. A serpentine micromixer, originally designed to mix two fluids in bulk solution via \"\"chaotic advection,\"\" is used to mix the sample as it passes through a surface plasmon resonance biosensor. These experiments indicate that such \"\"solution-based\"\" mixing strategies can be effective in microfluidic biosensors.\"","Made available in DSpace on 2015-09-25T20:44:19Z (GMT). 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