{"id":{"repo_id":"uiuc","oai_identifier":"oai:www.ideals.illinois.edu:2142/82378"},"canonical_url":"https://search.dev.ndltd.org/etd/uiuc/oai:www.ideals.illinois.edu:2142/82378","repository":{"repo_id":"uiuc","name":"University of Illinois - Urbana-Champaign","base_url":"https://www.ideals.illinois.edu/oai-pmh"},"display":{"title":"Interfacial Properties of Environmentally Responsive Polymers","abstract":"Direct force measurements quantified the substantial pH-dependent change in the molecular properties of end-grafted NIPAM-N-Gly-(C18) 2 monolayers. At pH 8.0, where the glycine side chains are ionized, the polymers exhibit stereotypical polyelectrolyte behavior. Side chain neutralization at pH 5.0 causes a substantial decrease in the film thickness, and the polymer films adhere strongly. The adhesion is presumably through H-bonding between the glycine side chains. Our findings revealed the likely molecular basis of pH-dependent changes in the copolymer films and identified clear design criteria for tuning the interfacial properties of these polymer films. In addition to the study of the interfacial properties of NIPAM-Gly copolymer, we also investigated the mucoadhesive properties using SFA and Surface Plasmon Resonance (SPR), and identify key parameters that control the interaction between hydrogen bonding polymers and soluble mucin.","abstract_html":"Direct force measurements quantified the substantial pH-dependent change in the molecular properties of end-grafted NIPAM-N-Gly-(C18) 2 monolayers. At pH 8.0, where the glycine side chains are ionized, the polymers exhibit stereotypical polyelectrolyte behavior. Side chain neutralization at pH 5.0 causes a substantial decrease in the film thickness, and the polymer films adhere strongly. The adhesion is presumably through H-bonding between the glycine side chains. Our findings revealed the likely molecular basis of pH-dependent changes in the copolymer films and identified clear design criteria for tuning the interfacial properties of these polymer films. In addition to the study of the interfacial properties of NIPAM-Gly copolymer, we also investigated the mucoadhesive properties using SFA and Surface Plasmon Resonance (SPR), and identify key parameters that control the interaction between hydrogen bonding polymers and soluble mucin.","abstract_has_math":false,"creators":["Zhu, Xi"],"institution":"University of Illinois at Urbana-Champaign","degree_name":"Ph.D.","degree_level":"Dissertation","degree_discipline":"Chemical Engineering","degree_department":null,"school":null,"contributors":["Deborah Leckband"],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2015,"date_issued":"2015-09-25T20:43:25Z","date_published":"2015-09-25T20:43:25Z","updated_at":"2026-07-22T22:26:18Z","subjects":["Chemistry, Polymer"],"languages":["eng"],"rights":[],"rights_urls":[],"identifier_entries":[{"key":"dc:identifier","label":"Identifier","values":["(MiAaPQ)AAI3199203"],"render_values":[{"text":"(MiAaPQ)AAI3199203","href":null,"code":true}]}]},"links":{"outbound_url":"http://hdl.handle.net/2142/82378","outbound_label":"Handle","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["Deborah Leckband"]},{"key":"dc:creator","label":"Author","values":["Zhu, Xi"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["2015-09-25T20:43:25Z","10000-01-01","2005"]},{"key":"dc:type","label":"Dc Type","values":["text"]},{"key":"thesis:degree_discipline","label":"Discipline","values":["Chemical Engineering"]},{"key":"thesis:degree_level","label":"Degree Level","values":["Dissertation"]},{"key":"thesis:degree_name","label":"Degree Name","values":["Ph.D."]},{"key":"thesis:institution_name","label":"Thesis Institution Name","values":["University of Illinois at Urbana-Champaign"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Chemistry, Polymer"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["eng"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["http://hdl.handle.net/2142/82378","(MiAaPQ)AAI3199203"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["Direct force measurements quantified the substantial pH-dependent change in the molecular properties of end-grafted NIPAM-N-Gly-(C18) 2 monolayers. At pH 8.0, where the glycine side chains are ionized, the polymers exhibit stereotypical polyelectrolyte behavior. Side chain neutralization at pH 5.0 causes a substantial decrease in the film thickness, and the polymer films adhere strongly. The adhesion is presumably through H-bonding between the glycine side chains. Our findings revealed the likely molecular basis of pH-dependent changes in the copolymer films and identified clear design criteria for tuning the interfacial properties of these polymer films. In addition to the study of the interfacial properties of NIPAM-Gly copolymer, we also investigated the mucoadhesive properties using SFA and Surface Plasmon Resonance (SPR), and identify key parameters that control the interaction between hydrogen bonding polymers and soluble mucin.","Made available in DSpace on 2015-09-25T20:43:25Z (GMT). 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At pH 8.0, where the glycine side chains are ionized, the polymers exhibit stereotypical polyelectrolyte behavior. Side chain neutralization at pH 5.0 causes a substantial decrease in the film thickness, and the polymer films adhere strongly. The adhesion is presumably through H-bonding between the glycine side chains. Our findings revealed the likely molecular basis of pH-dependent changes in the copolymer films and identified clear design criteria for tuning the interfacial properties of these polymer films. In addition to the study of the interfacial properties of NIPAM-Gly copolymer, we also investigated the mucoadhesive properties using SFA and Surface Plasmon Resonance (SPR), and identify key parameters that control the interaction between hydrogen bonding polymers and soluble mucin.","Made available in DSpace on 2015-09-25T20:43:25Z (GMT). No. of bitstreams: 2 license.txt: 4848 bytes, checksum: 96035ab3f5e1c23cc7138a224ce498bd (MD5) 3199203.pdf: 2784307 bytes, checksum: 70c2e87158dc4a5d0181913264fe6ab4 (MD5) Previous issue date: 2005","Embargo set by: Seth Robbins for item 83659 Lift date: Forever Reason: Restricted to the U of I community idenfinitely during batch ingest of legacy ETDs","Restricted to the U of I community idenfinitely during batch ingest of legacy ETDs","U of I Only","152 p.","Thesis (Ph.D.)--University of Illinois at Urbana-Champaign, 2005."],"dc:identifier":["http://hdl.handle.net/2142/82378","(MiAaPQ)AAI3199203"],"dc:language":["eng"],"dc:subject":["Chemistry, Polymer"],"dc:title":["Interfacial Properties of Environmentally Responsive Polymers"],"dc:type":["text"],"thesis:degree_discipline":["Chemical Engineering"],"thesis:degree_level":["Dissertation"],"thesis:degree_name":["Ph.D."],"thesis:institution_name":["University of Illinois at Urbana-Champaign"]},"updated_at":"2026-07-22T22:26:18Z"}