{"id":{"repo_id":"uiuc","oai_identifier":"oai:www.ideals.illinois.edu:2142/78797"},"canonical_url":"https://search.dev.ndltd.org/etd/uiuc/oai:www.ideals.illinois.edu:2142/78797","repository":{"repo_id":"uiuc","name":"University of Illinois - Urbana-Champaign","base_url":"https://www.ideals.illinois.edu/oai-pmh"},"display":{"title":"Silicon based photonic crystal coupled to an optical cavity for highly sensitive biodetection","abstract":"Since its discovery by Sir John Frederick William Herschel in 1845, fluorescence detection technology has developed extensively to be used in disease diagnosis, DNA sequencing, cellular imaging, flow cytometry, forensics, and monitoring processes in biological systems. In order to achieve better sensitivity and higher signal-to-noise ratio (SNR), metal-enhancement fluorescence and nano-engineered surfaces were used to augment the excitation of fluorophores and provide directionality to the emitted light for improved collection. Photonic crystals (PCs), which are composed of periodically refractive index modulated nano-structures, have proven to be a great surface for improving the emission from surface-bound fluorophores. When the resonant guided mode condition is reached, PCs provide fluorescence enhancement mainly through two mechanisms: enhanced excitation and enhanced extraction. This thesis addresses the design, fabrication, and characterization of a silicon based PC coupled to an optical cavity. Compared to an ordinary PC without coupled optical cavity, the new PC can further increase fluorescent output via stronger evanescent field. A fluorescent dye tagged protein detection experiment was conducted on the new PC showing that it provides 10x SNR, opening the door for detection of biomarkers in sub-pg/ml range.","abstract_html":"Since its discovery by Sir John Frederick William Herschel in 1845, fluorescence detection technology has developed extensively to be used in disease diagnosis, DNA sequencing, cellular imaging, flow cytometry, forensics, and monitoring processes in biological systems. In order to achieve better sensitivity and higher signal-to-noise ratio (SNR), metal-enhancement fluorescence and nano-engineered surfaces were used to augment the excitation of fluorophores and provide directionality to the emitted light for improved collection. Photonic crystals (PCs), which are composed of periodically refractive index modulated nano-structures, have proven to be a great surface for improving the emission from surface-bound fluorophores. When the resonant guided mode condition is reached, PCs provide fluorescence enhancement mainly through two mechanisms: enhanced excitation and enhanced extraction. This thesis addresses the design, fabrication, and characterization of a silicon based PC coupled to an optical cavity. Compared to an ordinary PC without coupled optical cavity, the new PC can further increase fluorescent output via stronger evanescent field. A fluorescent dye tagged protein detection experiment was conducted on the new PC showing that it provides 10x SNR, opening the door for detection of biomarkers in sub-pg/ml range.","abstract_has_math":false,"creators":["Tang, Tiantian"],"institution":"University of Illinois at Urbana-Champaign","degree_name":"M.S.","degree_level":"Thesis","degree_discipline":"Electrical & Computer Engr","degree_department":null,"school":null,"contributors":[],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2015,"date_issued":"2015-07-22T22:46:07Z","date_published":"2015-07-22T22:46:07Z","updated_at":"2026-07-22T22:26:12Z","subjects":["Photonic crystal enhanced fluorescence"],"languages":["en"],"rights":["Copyright 2015 Tiantian Tang"],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"http://hdl.handle.net/2142/78797","outbound_label":"Handle","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:creator","label":"Author","values":["Tang, Tiantian"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["2015-07-22T22:46:07Z","2017-07-23T09:15:32Z","2015-05","2015-05-01","2015-5"]},{"key":"dc:type","label":"Dc Type","values":["text"]},{"key":"thesis:degree_discipline","label":"Discipline","values":["Electrical & Computer Engr"]},{"key":"thesis:degree_level","label":"Degree Level","values":["Thesis"]},{"key":"thesis:degree_name","label":"Degree Name","values":["M.S."]},{"key":"thesis:institution_name","label":"Thesis Institution Name","values":["University of Illinois at Urbana-Champaign"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Photonic crystal enhanced fluorescence"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["en"]},{"key":"dc:rights","label":"Dc Rights","values":["Copyright 2015 Tiantian Tang"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["http://hdl.handle.net/2142/78797"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["Since its discovery by Sir John Frederick William Herschel in 1845, fluorescence detection technology has developed extensively to be used in disease diagnosis, DNA sequencing, cellular imaging, flow cytometry, forensics, and monitoring processes in biological systems. In order to achieve better sensitivity and higher signal-to-noise ratio (SNR), metal-enhancement fluorescence and nano-engineered surfaces were used to augment the excitation of fluorophores and provide directionality to the emitted light for improved collection. Photonic crystals (PCs), which are composed of periodically refractive index modulated nano-structures, have proven to be a great surface for improving the emission from surface-bound fluorophores. When the resonant guided mode condition is reached, PCs provide fluorescence enhancement mainly through two mechanisms: enhanced excitation and enhanced extraction. This thesis addresses the design, fabrication, and characterization of a silicon based PC coupled to an optical cavity. Compared to an ordinary PC without coupled optical cavity, the new PC can further increase fluorescent output via stronger evanescent field. A fluorescent dye tagged protein detection experiment was conducted on the new PC showing that it provides 10x SNR, opening the door for detection of biomarkers in sub-pg/ml range.","Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2017-05-01","The student, Tiantian Tang, accepted the attached license on 2015-04-29 at 17:04.","The student, Tiantian Tang, submitted this Thesis for approval on 2015-04-29 at 17:08.","This Thesis was approved for publication on 2015-05-01 at 10:26.","DSpace SAF Submission Ingestion Package generated from Vireo submission #8194 on 2015-07-22 at 14:26:35","Made available in DSpace on 2015-07-22T22:46:07Z (GMT). No. of bitstreams: 2 TANG-THESIS-2015.pdf: 2362136 bytes, checksum: cd59eac5bedaca0147def064fd02ed49 (MD5) LICENSE.txt: 4210 bytes, checksum: f8e4b04833ea411dcc94d732a9e0fcb1 (MD5) Previous issue date: 2015-05-01","Embargo set by: Seth Robbins for item 80038 Lift date: 2017-07-22T22:46:21Z Reason: Author requested closed access (OA after 2yrs) in Vireo ETD system","Limited Restriction Lifted for Item 80038 on 2017-07-23T09:15:32Z."]},{"key":"dc:format","label":"Dc Format","values":["application/pdf"]},{"key":"dc:title","label":"Title","values":["Silicon based photonic crystal coupled to an optical cavity for highly sensitive biodetection"]}]}],"canonical_facts":{"dc:creator":["Tang, Tiantian"],"dc:date":["2015-07-22T22:46:07Z","2017-07-23T09:15:32Z","2015-05","2015-05-01","2015-5"],"dc:description":["Since its discovery by Sir John Frederick William Herschel in 1845, fluorescence detection technology has developed extensively to be used in disease diagnosis, DNA sequencing, cellular imaging, flow cytometry, forensics, and monitoring processes in biological systems. In order to achieve better sensitivity and higher signal-to-noise ratio (SNR), metal-enhancement fluorescence and nano-engineered surfaces were used to augment the excitation of fluorophores and provide directionality to the emitted light for improved collection. Photonic crystals (PCs), which are composed of periodically refractive index modulated nano-structures, have proven to be a great surface for improving the emission from surface-bound fluorophores. When the resonant guided mode condition is reached, PCs provide fluorescence enhancement mainly through two mechanisms: enhanced excitation and enhanced extraction. This thesis addresses the design, fabrication, and characterization of a silicon based PC coupled to an optical cavity. Compared to an ordinary PC without coupled optical cavity, the new PC can further increase fluorescent output via stronger evanescent field. A fluorescent dye tagged protein detection experiment was conducted on the new PC showing that it provides 10x SNR, opening the door for detection of biomarkers in sub-pg/ml range.","Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2017-05-01","The student, Tiantian Tang, accepted the attached license on 2015-04-29 at 17:04.","The student, Tiantian Tang, submitted this Thesis for approval on 2015-04-29 at 17:08.","This Thesis was approved for publication on 2015-05-01 at 10:26.","DSpace SAF Submission Ingestion Package generated from Vireo submission #8194 on 2015-07-22 at 14:26:35","Made available in DSpace on 2015-07-22T22:46:07Z (GMT). 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