{"id":{"repo_id":"uiuc","oai_identifier":"oai:www.ideals.illinois.edu:2142/78773"},"canonical_url":"https://search.dev.ndltd.org/etd/uiuc/oai:www.ideals.illinois.edu:2142/78773","repository":{"repo_id":"uiuc","name":"University of Illinois - Urbana-Champaign","base_url":"https://www.ideals.illinois.edu/oai-pmh"},"display":{"title":"A multifaceted approach to addressing feeding intolerance in the preterm infant","abstract":"Limited Restriction Lifted for Item 80014 on 2017-07-23T09:15:33Z.","abstract_html":"Limited Restriction Lifted for Item 80014 on 2017-07-23T09:15:33Z.","abstract_has_math":false,"creators":["Naberhuis, Jane"],"institution":"University of Illinois at Urbana-Champaign","degree_name":"Ph.D.","degree_level":"Dissertation","degree_discipline":"Nutritional Sciences","degree_department":null,"school":null,"contributors":["Tappenden, Kelly A.","Teran-Garcia, Margarita","Swanson, Kelly S.","Soloveychik, Vitaliy"],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2015,"date_issued":"2015-07-22T22:45:57Z","date_published":"2015-07-22T22:45:57Z","updated_at":"2026-07-22T22:26:12Z","subjects":["Feeding intolerance","necrotizing enterocolitis","preterm","infant","teduglutide"],"languages":["en"],"rights":["Copyright 2015 Jane Kelly Naberhuis"],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"http://hdl.handle.net/2142/78773","outbound_label":"Handle","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["Tappenden, Kelly A.","Teran-Garcia, Margarita","Swanson, Kelly S.","Soloveychik, Vitaliy"]},{"key":"dc:creator","label":"Author","values":["Naberhuis, Jane"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["2015-07-22T22:45:57Z","2017-07-23T09:15:33Z","2015-05","2015-04-22","2015-5"]},{"key":"dc:type","label":"Dc Type","values":["text"]},{"key":"thesis:degree_discipline","label":"Discipline","values":["Nutritional Sciences"]},{"key":"thesis:degree_level","label":"Degree Level","values":["Dissertation"]},{"key":"thesis:degree_name","label":"Degree Name","values":["Ph.D."]},{"key":"thesis:institution_name","label":"Thesis Institution Name","values":["University of Illinois at Urbana-Champaign"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Feeding intolerance","necrotizing enterocolitis","preterm","infant","teduglutide"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["en"]},{"key":"dc:rights","label":"Dc Rights","values":["Copyright 2015 Jane Kelly Naberhuis"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["http://hdl.handle.net/2142/78773"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["Limited Restriction Lifted for Item 80014 on 2017-07-23T09:15:33Z.","In 2013, 11.4% of births in the United States occurred preterm.1 Due to the immaturity of the gastrointestinal tract, these infants are at increased risk of feeding intolerance and necrotizing enterocolitis (NEC). NEC is the most common surgical emergency among infants and proves fatal for 25-33% those diagnosed.2,3 Effective early detection of these conditions,4 combined with targeted therapies to promote intestinal adaptation and weaning from parenteral nutrition (PN), represent an important opportunity to improve infant outcomes. To this end, the following studies were conducted. 1. The safety and efficacy of teduglutide, an analog of human glucagon-like peptide-2 (GLP-2) approved for use only in adults, in reducing PN requirements was assessed via a systematic review.5 Fourteen reports met the inclusion criteria. Teduglutide reduced PN requirements vs. placebo regardless of PN dependence duration, whereas adverse event incidence was similar between groups (number needed to treat to benefit [NNTB] = 3-4; number needed to treat to harm [NNTH] = 24-187). 2. Teduglutide-stimulated intestinal adaptation, potential synergies with partial enteral nutrition (PEN), and distinct temporal markers of adaptation were investigated in a neonatal piglet model of short bowel syndrome (SBS). Teduglutide improved (P < 0.05) mucosal surface area (villus height: duodenum, jejunum, ileum; crypt depth: ileum, colon; proliferation: duodenum, jejunum, ileum, colon; apoptosis: jejunum, ileum, colon) and acute nutrient processing capacity (glucose: duodenum, jejunum, ileum; glutamine: duodenum, jejunum). PEN complimented and synergistically enhanced these effects. Structural adaptation preceded functional adaptation, but crypt depth was a strong indicator of adaptation, regardless of time. 3. A novel feeding intolerance and NEC risk scoring tool was implemented in the University of Illinois-affiliated Carle Foundation Hospital (CFH) level III neonatal intensive care unit (NICU). During the study period, 499 tools were completed on the 133 enrolled infants. Indices of feeding intolerance included days with emesis, abdominal distention, or gastric residuals > 50% of previous feeding volume, and NEC. Anonymous surveys (n = 42) indicated nurses’ positive attitudes toward the tool (ease of use of 6.9 [SD 1.9] on 10-point scale). Estimated tool completion time was 4.2 minutes (range 1-10). Error rate (9.2%), Cronbach’s alpha (0.71), the intraclass correlation coefficient (ICC; 0.99), and Fleiss’ kappa (1.00) were in acceptable ranges. Gestational age at birth, hypoxia/asphyxia at birth, red blood cell (RBC) transfusion, and congenital heart disease/patent ductus arteriosis (PDA) were significantly associated with all four outcome measures. Total optimized tool score was also associated with all four outcome measures, with area under the ROC curve (AUC) and diagnostic odds ratio (OR) estimates [95% CI] of: emesis, AUC = 0.69 and OR = 1.14 [1.06, 1.23]; abdominal distention, AUC = 0.82 and OR = 1.28 [1.18, 1.41]; gastric residuals > 50% of previous feeding volume, AUC = 0.64 and OR = 1.11 [1.04, 1.20]; NEC, AUC = 0.90 and OR = 1.29 [1.12, 1.56]. Scores of infants who did and did not develop each of the four outcome measures were significantly (P < 0.05) different, and an “at-risk” threshold of 9 points was established. The tool represents a clinically feasible means to discriminate infants at risk of feeding intolerance and NEC. Further refinement will improve its clinical utility and identify infants who may benefit from targeted therapies, including teduglutide and/or PEN, to promote gastrointestinal maturation and improve feeding tolerance. REFERENCES 1. Martin J, Hamilton B, Osterman M, Curtin S, Mathews T. Births: final data for 2013. Natl Vital Stat Rep 2015;64(1):1-65. 2. Henry M, Moss R. Current issues in the management of necrotizing enterocolitis. Semin Perinatol 2004;28:221-233. 3. Lin P, Stoll B. Necrotising enterocolitis. Lancet 2006;368:1271-1283. 4. Neu J, Walker W. Necrotizing enterocolitis. N Engl J Med 2011;364:255-264. 5. Higgins J, Green S (eds). Cochrane Handbook for Systematic Reviews of Interventions, version 5.1.0. The Cochrane Collaboration 2011.","Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2017-05-01","The student, Jane Naberhuis, accepted the attached license on 2015-04-22 at 11:30.","The student, Jane Naberhuis, submitted this Dissertation for approval on 2015-04-22 at 11:38.","This Dissertation was approved for publication on 2015-04-22 at 15:54.","DSpace SAF Submission Ingestion Package generated from Vireo submission #8017 on 2015-07-22 at 14:26:19","Made available in DSpace on 2015-07-22T22:45:57Z (GMT). No. of bitstreams: 2 NABERHUIS-DISSERTATION-2015.pdf: 1650791 bytes, checksum: 081a0a530a10418de5a4ecee2bf2dfa7 (MD5) LICENSE.txt: 4211 bytes, checksum: 3f647f118c6ecc9ac1c24e8e3be6be14 (MD5) Previous issue date: 2015-04-22","Embargo set by: Seth Robbins for item 80014 Lift date: 2017-07-22T22:46:21Z Reason: Author requested closed access (OA after 2yrs) in Vireo ETD system"]},{"key":"dc:format","label":"Dc Format","values":["application/pdf"]},{"key":"dc:title","label":"Title","values":["A multifaceted approach to addressing feeding intolerance in the preterm infant"]}]}],"canonical_facts":{"dc:contributor":["Tappenden, Kelly A.","Teran-Garcia, Margarita","Swanson, Kelly S.","Soloveychik, Vitaliy"],"dc:creator":["Naberhuis, Jane"],"dc:date":["2015-07-22T22:45:57Z","2017-07-23T09:15:33Z","2015-05","2015-04-22","2015-5"],"dc:description":["Limited Restriction Lifted for Item 80014 on 2017-07-23T09:15:33Z.","In 2013, 11.4% of births in the United States occurred preterm.1 Due to the immaturity of the gastrointestinal tract, these infants are at increased risk of feeding intolerance and necrotizing enterocolitis (NEC). NEC is the most common surgical emergency among infants and proves fatal for 25-33% those diagnosed.2,3 Effective early detection of these conditions,4 combined with targeted therapies to promote intestinal adaptation and weaning from parenteral nutrition (PN), represent an important opportunity to improve infant outcomes. To this end, the following studies were conducted. 1. The safety and efficacy of teduglutide, an analog of human glucagon-like peptide-2 (GLP-2) approved for use only in adults, in reducing PN requirements was assessed via a systematic review.5 Fourteen reports met the inclusion criteria. Teduglutide reduced PN requirements vs. placebo regardless of PN dependence duration, whereas adverse event incidence was similar between groups (number needed to treat to benefit [NNTB] = 3-4; number needed to treat to harm [NNTH] = 24-187). 2. Teduglutide-stimulated intestinal adaptation, potential synergies with partial enteral nutrition (PEN), and distinct temporal markers of adaptation were investigated in a neonatal piglet model of short bowel syndrome (SBS). Teduglutide improved (P < 0.05) mucosal surface area (villus height: duodenum, jejunum, ileum; crypt depth: ileum, colon; proliferation: duodenum, jejunum, ileum, colon; apoptosis: jejunum, ileum, colon) and acute nutrient processing capacity (glucose: duodenum, jejunum, ileum; glutamine: duodenum, jejunum). PEN complimented and synergistically enhanced these effects. Structural adaptation preceded functional adaptation, but crypt depth was a strong indicator of adaptation, regardless of time. 3. A novel feeding intolerance and NEC risk scoring tool was implemented in the University of Illinois-affiliated Carle Foundation Hospital (CFH) level III neonatal intensive care unit (NICU). During the study period, 499 tools were completed on the 133 enrolled infants. Indices of feeding intolerance included days with emesis, abdominal distention, or gastric residuals > 50% of previous feeding volume, and NEC. Anonymous surveys (n = 42) indicated nurses’ positive attitudes toward the tool (ease of use of 6.9 [SD 1.9] on 10-point scale). Estimated tool completion time was 4.2 minutes (range 1-10). Error rate (9.2%), Cronbach’s alpha (0.71), the intraclass correlation coefficient (ICC; 0.99), and Fleiss’ kappa (1.00) were in acceptable ranges. Gestational age at birth, hypoxia/asphyxia at birth, red blood cell (RBC) transfusion, and congenital heart disease/patent ductus arteriosis (PDA) were significantly associated with all four outcome measures. Total optimized tool score was also associated with all four outcome measures, with area under the ROC curve (AUC) and diagnostic odds ratio (OR) estimates [95% CI] of: emesis, AUC = 0.69 and OR = 1.14 [1.06, 1.23]; abdominal distention, AUC = 0.82 and OR = 1.28 [1.18, 1.41]; gastric residuals > 50% of previous feeding volume, AUC = 0.64 and OR = 1.11 [1.04, 1.20]; NEC, AUC = 0.90 and OR = 1.29 [1.12, 1.56]. Scores of infants who did and did not develop each of the four outcome measures were significantly (P < 0.05) different, and an “at-risk” threshold of 9 points was established. The tool represents a clinically feasible means to discriminate infants at risk of feeding intolerance and NEC. Further refinement will improve its clinical utility and identify infants who may benefit from targeted therapies, including teduglutide and/or PEN, to promote gastrointestinal maturation and improve feeding tolerance. REFERENCES 1. Martin J, Hamilton B, Osterman M, Curtin S, Mathews T. Births: final data for 2013. Natl Vital Stat Rep 2015;64(1):1-65. 2. Henry M, Moss R. Current issues in the management of necrotizing enterocolitis. Semin Perinatol 2004;28:221-233. 3. Lin P, Stoll B. Necrotising enterocolitis. Lancet 2006;368:1271-1283. 4. Neu J, Walker W. Necrotizing enterocolitis. N Engl J Med 2011;364:255-264. 5. Higgins J, Green S (eds). Cochrane Handbook for Systematic Reviews of Interventions, version 5.1.0. The Cochrane Collaboration 2011.","Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2017-05-01","The student, Jane Naberhuis, accepted the attached license on 2015-04-22 at 11:30.","The student, Jane Naberhuis, submitted this Dissertation for approval on 2015-04-22 at 11:38.","This Dissertation was approved for publication on 2015-04-22 at 15:54.","DSpace SAF Submission Ingestion Package generated from Vireo submission #8017 on 2015-07-22 at 14:26:19","Made available in DSpace on 2015-07-22T22:45:57Z (GMT). No. of bitstreams: 2 NABERHUIS-DISSERTATION-2015.pdf: 1650791 bytes, checksum: 081a0a530a10418de5a4ecee2bf2dfa7 (MD5) LICENSE.txt: 4211 bytes, checksum: 3f647f118c6ecc9ac1c24e8e3be6be14 (MD5) Previous issue date: 2015-04-22","Embargo set by: Seth Robbins for item 80014 Lift date: 2017-07-22T22:46:21Z Reason: Author requested closed access (OA after 2yrs) in Vireo ETD system"],"dc:format":["application/pdf"],"dc:identifier":["http://hdl.handle.net/2142/78773"],"dc:language":["en"],"dc:rights":["Copyright 2015 Jane Kelly Naberhuis"],"dc:subject":["Feeding intolerance","necrotizing enterocolitis","preterm","infant","teduglutide"],"dc:title":["A multifaceted approach to addressing feeding intolerance in the preterm infant"],"dc:type":["text"],"thesis:degree_discipline":["Nutritional Sciences"],"thesis:degree_level":["Dissertation"],"thesis:degree_name":["Ph.D."],"thesis:institution_name":["University of Illinois at Urbana-Champaign"]},"updated_at":"2026-07-22T22:26:12Z"}