{"id":{"repo_id":"uiuc","oai_identifier":"oai:www.ideals.illinois.edu:2142/78729"},"canonical_url":"https://search.dev.ndltd.org/etd/uiuc/oai:www.ideals.illinois.edu:2142/78729","repository":{"repo_id":"uiuc","name":"University of Illinois - Urbana-Champaign","base_url":"https://www.ideals.illinois.edu/oai-pmh"},"display":{"title":"Biomechanical regulation of epigenetics and chromatin organization in single living cells","abstract":"Mechanical forces are known to play a key role in regulating various cellular functions that control human development, cancer, disease, and aging. It, however, remains elusive how mechanical cues regulate biochemical mechanisms in the nucleus that control cellular decision-making. These mechanisms include epigenetic modification, chromatin organization, and gene expression. It is, therefore, highly important to investigate force-induced regulation of these mechanisms to better understand human physiology and disease. In this research, we aim at answering two key questions: one, how mechanical forces regulate epigenetics in tumor repopulating cells (TRCs), and two, how these forces unfold chromatin and induce gene expression in single living cells. Our findings suggest that mechanical forces play critical roles in regulating nuclear structure and function. Biomechanical cues can propagate deep inside the nucleus and regulate epigenetics, chromatin organization, and gene expression.","abstract_html":"Mechanical forces are known to play a key role in regulating various cellular functions that control human development, cancer, disease, and aging. It, however, remains elusive how mechanical cues regulate biochemical mechanisms in the nucleus that control cellular decision-making. These mechanisms include epigenetic modification, chromatin organization, and gene expression. It is, therefore, highly important to investigate force-induced regulation of these mechanisms to better understand human physiology and disease. In this research, we aim at answering two key questions: one, how mechanical forces regulate epigenetics in tumor repopulating cells (TRCs), and two, how these forces unfold chromatin and induce gene expression in single living cells. Our findings suggest that mechanical forces play critical roles in regulating nuclear structure and function. Biomechanical cues can propagate deep inside the nucleus and regulate epigenetics, chromatin organization, and gene expression.","abstract_has_math":false,"creators":["Tajik, Arash"],"institution":"University of Illinois at Urbana-Champaign","degree_name":"Ph.D.","degree_level":"Dissertation","degree_discipline":"Mechanical Engineering","degree_department":null,"school":null,"contributors":["Wang, Ning","Wang, Yingxiao","Cheng, Jianjun","Nam, SungWoo","Ma, Jian"],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2015,"date_issued":"2015-07-22T22:45:14Z","date_published":"2015-07-22T22:45:14Z","updated_at":"2026-07-22T22:26:12Z","subjects":["Biomechanics","Cell Mechanics","Mechanotransduction","Epigenetics","Chromatin Organization"],"languages":["en"],"rights":["Copyright 2015 Arash Tajik"],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"http://hdl.handle.net/2142/78729","outbound_label":"Handle","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["Wang, Ning","Wang, Yingxiao","Cheng, Jianjun","Nam, SungWoo","Ma, Jian"]},{"key":"dc:creator","label":"Author","values":["Tajik, Arash"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["2015-07-22T22:45:14Z","2017-07-23T09:15:27Z","2015-05","2015-04-13","2015-5"]},{"key":"dc:type","label":"Dc Type","values":["text"]},{"key":"thesis:degree_discipline","label":"Discipline","values":["Mechanical Engineering"]},{"key":"thesis:degree_level","label":"Degree Level","values":["Dissertation"]},{"key":"thesis:degree_name","label":"Degree Name","values":["Ph.D."]},{"key":"thesis:institution_name","label":"Thesis Institution Name","values":["University of Illinois at Urbana-Champaign"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Biomechanics","Cell Mechanics","Mechanotransduction","Epigenetics","Chromatin Organization"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["en"]},{"key":"dc:rights","label":"Dc Rights","values":["Copyright 2015 Arash Tajik"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["http://hdl.handle.net/2142/78729"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["Mechanical forces are known to play a key role in regulating various cellular functions that control human development, cancer, disease, and aging. It, however, remains elusive how mechanical cues regulate biochemical mechanisms in the nucleus that control cellular decision-making. These mechanisms include epigenetic modification, chromatin organization, and gene expression. It is, therefore, highly important to investigate force-induced regulation of these mechanisms to better understand human physiology and disease. In this research, we aim at answering two key questions: one, how mechanical forces regulate epigenetics in tumor repopulating cells (TRCs), and two, how these forces unfold chromatin and induce gene expression in single living cells. Our findings suggest that mechanical forces play critical roles in regulating nuclear structure and function. Biomechanical cues can propagate deep inside the nucleus and regulate epigenetics, chromatin organization, and gene expression.","Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2017-05-01","The student, Arash Tajik, accepted the attached license on 2015-04-10 at 15:37.","The student, Arash Tajik, submitted this Dissertation for approval on 2015-04-10 at 15:45.","This Dissertation was approved for publication on 2015-04-13 at 14:33.","DSpace SAF Submission Ingestion Package generated from Vireo submission #7818 on 2015-07-22 at 14:24:21","Made available in DSpace on 2015-07-22T22:45:14Z (GMT). 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It, however, remains elusive how mechanical cues regulate biochemical mechanisms in the nucleus that control cellular decision-making. These mechanisms include epigenetic modification, chromatin organization, and gene expression. It is, therefore, highly important to investigate force-induced regulation of these mechanisms to better understand human physiology and disease. In this research, we aim at answering two key questions: one, how mechanical forces regulate epigenetics in tumor repopulating cells (TRCs), and two, how these forces unfold chromatin and induce gene expression in single living cells. Our findings suggest that mechanical forces play critical roles in regulating nuclear structure and function. Biomechanical cues can propagate deep inside the nucleus and regulate epigenetics, chromatin organization, and gene expression.","Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2017-05-01","The student, Arash Tajik, accepted the attached license on 2015-04-10 at 15:37.","The student, Arash Tajik, submitted this Dissertation for approval on 2015-04-10 at 15:45.","This Dissertation was approved for publication on 2015-04-13 at 14:33.","DSpace SAF Submission Ingestion Package generated from Vireo submission #7818 on 2015-07-22 at 14:24:21","Made available in DSpace on 2015-07-22T22:45:14Z (GMT). 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