{"id":{"repo_id":"uiuc","oai_identifier":"oai:www.ideals.illinois.edu:2142/78560"},"canonical_url":"https://search.dev.ndltd.org/etd/uiuc/oai:www.ideals.illinois.edu:2142/78560","repository":{"repo_id":"uiuc","name":"University of Illinois - Urbana-Champaign","base_url":"https://www.ideals.illinois.edu/oai-pmh"},"display":{"title":"Cell migration and alignment on mechanically controlled environment","abstract":"This thesis studies the effect of mechanically controlled environment on cell migration and alignment in vitro. Understanding such behaviors are necessary to study wound healing of life, metastatic of cancer cells, tissue engineering, and regenerative medicines. First study is a cell migration behavior on stiffness controlled three-dimensional in vitro environment. The continuous stiffness gradient 3D environment is provided by the effective stiffness on a PDMS wavy pattern, and the relationship between stiffness gradient and the cell migration is analyzed. Next, the effect of cell-cell interaction on cell alignment on a PDMS wavy pattern is studied. The previous study about the cell alignment behavior with feature characteristics is repeated for further research. Lastly, we look at the cell development behavior on various micro scale structures. Tubule etching structures, ribbon-like 3D structures, and table structures are explored to observe the cell growth, migration, alignment, and even the effect of cells on those structures. Studying the mechanically controlled environment on cells would provide easier and more precise controllable methods for tissues engineering and regenerative medicine.","abstract_html":"This thesis studies the effect of mechanically controlled environment on cell migration and alignment in vitro. Understanding such behaviors are necessary to study wound healing of life, metastatic of cancer cells, tissue engineering, and regenerative medicines. First study is a cell migration behavior on stiffness controlled three-dimensional in vitro environment. The continuous stiffness gradient 3D environment is provided by the effective stiffness on a PDMS wavy pattern, and the relationship between stiffness gradient and the cell migration is analyzed. Next, the effect of cell-cell interaction on cell alignment on a PDMS wavy pattern is studied. The previous study about the cell alignment behavior with feature characteristics is repeated for further research. Lastly, we look at the cell development behavior on various micro scale structures. Tubule etching structures, ribbon-like 3D structures, and table structures are explored to observe the cell growth, migration, alignment, and even the effect of cells on those structures. Studying the mechanically controlled environment on cells would provide easier and more precise controllable methods for tissues engineering and regenerative medicine.","abstract_has_math":false,"creators":["Kwon, Gubeum"],"institution":"University of Illinois at Urbana-Champaign","degree_name":"M.S.","degree_level":"Thesis","degree_discipline":"Mechanical Engineering","degree_department":null,"school":null,"contributors":[],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2015,"date_issued":"2015-07-22T22:18:17Z","date_published":"2015-07-22T22:18:17Z","updated_at":"2026-07-22T22:26:11Z","subjects":["cell migration","cell alignment","contact guidance","cell-matrix interaction"],"languages":["en"],"rights":["Copyright 2015 Gubeum Kwon"],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"http://hdl.handle.net/2142/78560","outbound_label":"Handle","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:creator","label":"Author","values":["Kwon, Gubeum"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["2015-07-22T22:18:17Z","2015-05","2015-05-01","2015-5"]},{"key":"dc:type","label":"Dc Type","values":["text"]},{"key":"thesis:degree_discipline","label":"Discipline","values":["Mechanical Engineering"]},{"key":"thesis:degree_level","label":"Degree Level","values":["Thesis"]},{"key":"thesis:degree_name","label":"Degree Name","values":["M.S."]},{"key":"thesis:institution_name","label":"Thesis Institution Name","values":["University of Illinois at Urbana-Champaign"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["cell migration","cell alignment","contact guidance","cell-matrix interaction"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["en"]},{"key":"dc:rights","label":"Dc Rights","values":["Copyright 2015 Gubeum Kwon"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["http://hdl.handle.net/2142/78560"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["This thesis studies the effect of mechanically controlled environment on cell migration and alignment in vitro. Understanding such behaviors are necessary to study wound healing of life, metastatic of cancer cells, tissue engineering, and regenerative medicines. First study is a cell migration behavior on stiffness controlled three-dimensional in vitro environment. The continuous stiffness gradient 3D environment is provided by the effective stiffness on a PDMS wavy pattern, and the relationship between stiffness gradient and the cell migration is analyzed. Next, the effect of cell-cell interaction on cell alignment on a PDMS wavy pattern is studied. The previous study about the cell alignment behavior with feature characteristics is repeated for further research. Lastly, we look at the cell development behavior on various micro scale structures. Tubule etching structures, ribbon-like 3D structures, and table structures are explored to observe the cell growth, migration, alignment, and even the effect of cells on those structures. Studying the mechanically controlled environment on cells would provide easier and more precise controllable methods for tissues engineering and regenerative medicine.","Submission original under an indefinite embargo labeled 'Open Access'. The submission was exported from vireo on 2015-07-22 without embargo terms","The student, Gubeum Kwon, accepted the attached license on 2015-04-30 at 10:24.","The student, Gubeum Kwon, submitted this Thesis for approval on 2015-04-30 at 10:35.","This Thesis was approved for publication on 2015-05-01 at 11:03.","DSpace SAF Submission Ingestion Package generated from Vireo submission #8209 on 2015-07-22 at 10:35:09","Made available in DSpace on 2015-07-22T22:18:17Z (GMT). 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The continuous stiffness gradient 3D environment is provided by the effective stiffness on a PDMS wavy pattern, and the relationship between stiffness gradient and the cell migration is analyzed. Next, the effect of cell-cell interaction on cell alignment on a PDMS wavy pattern is studied. The previous study about the cell alignment behavior with feature characteristics is repeated for further research. Lastly, we look at the cell development behavior on various micro scale structures. Tubule etching structures, ribbon-like 3D structures, and table structures are explored to observe the cell growth, migration, alignment, and even the effect of cells on those structures. Studying the mechanically controlled environment on cells would provide easier and more precise controllable methods for tissues engineering and regenerative medicine.","Submission original under an indefinite embargo labeled 'Open Access'. The submission was exported from vireo on 2015-07-22 without embargo terms","The student, Gubeum Kwon, accepted the attached license on 2015-04-30 at 10:24.","The student, Gubeum Kwon, submitted this Thesis for approval on 2015-04-30 at 10:35.","This Thesis was approved for publication on 2015-05-01 at 11:03.","DSpace SAF Submission Ingestion Package generated from Vireo submission #8209 on 2015-07-22 at 10:35:09","Made available in DSpace on 2015-07-22T22:18:17Z (GMT). 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