{"id":{"repo_id":"uiuc","oai_identifier":"oai:www.ideals.illinois.edu:2142/78550"},"canonical_url":"https://search.dev.ndltd.org/etd/uiuc/oai:www.ideals.illinois.edu:2142/78550","repository":{"repo_id":"uiuc","name":"University of Illinois - Urbana-Champaign","base_url":"https://www.ideals.illinois.edu/oai-pmh"},"display":{"title":"Physical fitness and cardiovascular function in multiple sclerosis","abstract":"Multiple sclerosis (MS) is an immune-mediated neurodegenerative disease that affects the central nervous system. Cardiovascular function (CV) has been shown to be impaired in persons with MS which can lead to the development of comorbidities that can promote disability progression. Cardiorespiratory fitness (CRF) and, to a lesser extent, muscular fitness (MF) have been shown to improve CV function in healthy populations. This thesis examined the relationships between CRF, MF, and exercise presented by randomized controlled trials via meta-analysis. Then, the relationships between CRF, MF, and CV function in persons with MS was determined in order to determine targets for therapy that might improve CV function. Results suggest exercise training improved CRF and MF in RCTs of exercise training examining CRF and MF outcomes. Further, the results of this cross-sectional study indicate significant relationships exist between CRF, MF and CV function in persons with MS. These studies support the potential to improve physiological fitness through exercise training as a possible means to improve CV function in persons with MS. This might be accomplished through exercise training interventions involving aerobic and/or resistance exercise.","abstract_html":"Multiple sclerosis (MS) is an immune-mediated neurodegenerative disease that affects the central nervous system. Cardiovascular function (CV) has been shown to be impaired in persons with MS which can lead to the development of comorbidities that can promote disability progression. Cardiorespiratory fitness (CRF) and, to a lesser extent, muscular fitness (MF) have been shown to improve CV function in healthy populations. This thesis examined the relationships between CRF, MF, and exercise presented by randomized controlled trials via meta-analysis. Then, the relationships between CRF, MF, and CV function in persons with MS was determined in order to determine targets for therapy that might improve CV function. Results suggest exercise training improved CRF and MF in RCTs of exercise training examining CRF and MF outcomes. Further, the results of this cross-sectional study indicate significant relationships exist between CRF, MF and CV function in persons with MS. These studies support the potential to improve physiological fitness through exercise training as a possible means to improve CV function in persons with MS. This might be accomplished through exercise training interventions involving aerobic and/or resistance exercise.","abstract_has_math":false,"creators":["Platta, Matthew E."],"institution":"University of Illinois at Urbana-Champaign","degree_name":"M.S.","degree_level":"Thesis","degree_discipline":"Kinesiology","degree_department":null,"school":null,"contributors":[],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2015,"date_issued":"2015-07-22T22:18:10Z","date_published":"2015-07-22T22:18:10Z","updated_at":"2026-07-22T22:26:11Z","subjects":["multiples sclerosis","exercise","respiratory fitness","muscular fitness","fitness","arterial function","cardiovascular"],"languages":["en"],"rights":["Copyright 2015 Matthew Platta"],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"http://hdl.handle.net/2142/78550","outbound_label":"Handle","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:creator","label":"Author","values":["Platta, Matthew E."]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["2015-07-22T22:18:10Z","2015-05","2015-04-30","2015-5"]},{"key":"dc:type","label":"Dc Type","values":["text"]},{"key":"thesis:degree_discipline","label":"Discipline","values":["Kinesiology"]},{"key":"thesis:degree_level","label":"Degree Level","values":["Thesis"]},{"key":"thesis:degree_name","label":"Degree Name","values":["M.S."]},{"key":"thesis:institution_name","label":"Thesis Institution Name","values":["University of Illinois at Urbana-Champaign"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["multiples sclerosis","exercise","respiratory fitness","muscular fitness","fitness","arterial function","cardiovascular"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["en"]},{"key":"dc:rights","label":"Dc Rights","values":["Copyright 2015 Matthew Platta"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["http://hdl.handle.net/2142/78550"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["Multiple sclerosis (MS) is an immune-mediated neurodegenerative disease that affects the central nervous system. Cardiovascular function (CV) has been shown to be impaired in persons with MS which can lead to the development of comorbidities that can promote disability progression. Cardiorespiratory fitness (CRF) and, to a lesser extent, muscular fitness (MF) have been shown to improve CV function in healthy populations. This thesis examined the relationships between CRF, MF, and exercise presented by randomized controlled trials via meta-analysis. Then, the relationships between CRF, MF, and CV function in persons with MS was determined in order to determine targets for therapy that might improve CV function. Results suggest exercise training improved CRF and MF in RCTs of exercise training examining CRF and MF outcomes. Further, the results of this cross-sectional study indicate significant relationships exist between CRF, MF and CV function in persons with MS. These studies support the potential to improve physiological fitness through exercise training as a possible means to improve CV function in persons with MS. This might be accomplished through exercise training interventions involving aerobic and/or resistance exercise.","Submission original under an indefinite embargo labeled 'Open Access'. The submission was exported from vireo on 2015-07-22 without embargo terms","The student, Matthew Platta, accepted the attached license on 2015-04-29 at 15:54.","The student, Matthew Platta, submitted this Thesis for approval on 2015-04-29 at 16:01.","This Thesis was approved for publication on 2015-04-30 at 14:21.","DSpace SAF Submission Ingestion Package generated from Vireo submission #8193 on 2015-07-22 at 10:34:55","Made available in DSpace on 2015-07-22T22:18:10Z (GMT). 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This thesis examined the relationships between CRF, MF, and exercise presented by randomized controlled trials via meta-analysis. Then, the relationships between CRF, MF, and CV function in persons with MS was determined in order to determine targets for therapy that might improve CV function. Results suggest exercise training improved CRF and MF in RCTs of exercise training examining CRF and MF outcomes. Further, the results of this cross-sectional study indicate significant relationships exist between CRF, MF and CV function in persons with MS. These studies support the potential to improve physiological fitness through exercise training as a possible means to improve CV function in persons with MS. This might be accomplished through exercise training interventions involving aerobic and/or resistance exercise.","Submission original under an indefinite embargo labeled 'Open Access'. The submission was exported from vireo on 2015-07-22 without embargo terms","The student, Matthew Platta, accepted the attached license on 2015-04-29 at 15:54.","The student, Matthew Platta, submitted this Thesis for approval on 2015-04-29 at 16:01.","This Thesis was approved for publication on 2015-04-30 at 14:21.","DSpace SAF Submission Ingestion Package generated from Vireo submission #8193 on 2015-07-22 at 10:34:55","Made available in DSpace on 2015-07-22T22:18:10Z (GMT). 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