{"id":{"repo_id":"uiuc","oai_identifier":"oai:www.ideals.illinois.edu:2142/78531"},"canonical_url":"https://search.dev.ndltd.org/etd/uiuc/oai:www.ideals.illinois.edu:2142/78531","repository":{"repo_id":"uiuc","name":"University of Illinois - Urbana-Champaign","base_url":"https://www.ideals.illinois.edu/oai-pmh"},"display":{"title":"Tyrosine hydroxylase immunoreactive fibers in the upper layers of the adolescent rat medial prefrontal cortex","abstract":"Adolescence is an important period of maturation for the brain. In particular, the medial prefrontal cortex continues developing throughout adolescence and is responsible for a number of executive and cognitive functions. Innervation of the medial prefrontal cortex by the dopaminergic system contributes to some of these maturing behaviors and the dopaminergic system is implicated in mental illnesses. However, much previous work on medial prefrontal cortex development over adolescence has considered only one sex or has failed to capture timing of changes. Here, the development of tyrosine hydroxylase-immunoreactive axons, to indicate dopaminergic innervation, in the upper layers of the medial prefrontal cortex was examined in both sexes of Long-Evans rats during five ages from postnatal day 25 to 90. Tyrosine hydroxylase-immunoreactive axon density was found to increase over the course of adolescence, with the most marked increases being prepubertal in both males and females. No sex differences were identified. These results suggest a similar development, and thus similar susceptibility to disruption, of the dopaminergic system in the rat medial prefrontal cortex in both sexes.","abstract_html":"Adolescence is an important period of maturation for the brain. In particular, the medial prefrontal cortex continues developing throughout adolescence and is responsible for a number of executive and cognitive functions. Innervation of the medial prefrontal cortex by the dopaminergic system contributes to some of these maturing behaviors and the dopaminergic system is implicated in mental illnesses. However, much previous work on medial prefrontal cortex development over adolescence has considered only one sex or has failed to capture timing of changes. Here, the development of tyrosine hydroxylase-immunoreactive axons, to indicate dopaminergic innervation, in the upper layers of the medial prefrontal cortex was examined in both sexes of Long-Evans rats during five ages from postnatal day 25 to 90. Tyrosine hydroxylase-immunoreactive axon density was found to increase over the course of adolescence, with the most marked increases being prepubertal in both males and females. No sex differences were identified. These results suggest a similar development, and thus similar susceptibility to disruption, of the dopaminergic system in the rat medial prefrontal cortex in both sexes.","abstract_has_math":false,"creators":["Brodsky, Joseph Michael"],"institution":"University of Illinois at Urbana-Champaign","degree_name":"M.S.","degree_level":"Thesis","degree_discipline":"Biology","degree_department":null,"school":null,"contributors":[],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2015,"date_issued":"2015-07-22T22:18:00Z","date_published":"2015-07-22T22:18:00Z","updated_at":"2026-07-22T22:26:11Z","subjects":["Adolescence","Dopamine","prefrontal cortex","Rat","Sex Differences"],"languages":["en"],"rights":["Copyright 2015 Joseph Brodsky"],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"http://hdl.handle.net/2142/78531","outbound_label":"Handle","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:creator","label":"Author","values":["Brodsky, Joseph Michael"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["2015-07-22T22:18:00Z","2015-05","2015-04-30","2015-5"]},{"key":"dc:type","label":"Dc Type","values":["text"]},{"key":"thesis:degree_discipline","label":"Discipline","values":["Biology"]},{"key":"thesis:degree_level","label":"Degree Level","values":["Thesis"]},{"key":"thesis:degree_name","label":"Degree Name","values":["M.S."]},{"key":"thesis:institution_name","label":"Thesis Institution Name","values":["University of Illinois at Urbana-Champaign"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Adolescence","Dopamine","prefrontal cortex","Rat","Sex Differences"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["en"]},{"key":"dc:rights","label":"Dc Rights","values":["Copyright 2015 Joseph Brodsky"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["http://hdl.handle.net/2142/78531"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["Adolescence is an important period of maturation for the brain. In particular, the medial prefrontal cortex continues developing throughout adolescence and is responsible for a number of executive and cognitive functions. Innervation of the medial prefrontal cortex by the dopaminergic system contributes to some of these maturing behaviors and the dopaminergic system is implicated in mental illnesses. However, much previous work on medial prefrontal cortex development over adolescence has considered only one sex or has failed to capture timing of changes. Here, the development of tyrosine hydroxylase-immunoreactive axons, to indicate dopaminergic innervation, in the upper layers of the medial prefrontal cortex was examined in both sexes of Long-Evans rats during five ages from postnatal day 25 to 90. Tyrosine hydroxylase-immunoreactive axon density was found to increase over the course of adolescence, with the most marked increases being prepubertal in both males and females. No sex differences were identified. These results suggest a similar development, and thus similar susceptibility to disruption, of the dopaminergic system in the rat medial prefrontal cortex in both sexes.","Submission original under an indefinite embargo labeled 'Open Access'. The submission was exported from vireo on 2015-07-22 without embargo terms","The student, Joseph Brodsky, accepted the attached license on 2015-04-28 at 14:23.","The student, Joseph Brodsky, submitted this Thesis for approval on 2015-04-28 at 14:34.","This Thesis was approved for publication on 2015-04-30 at 11:21.","DSpace SAF Submission Ingestion Package generated from Vireo submission #8162 on 2015-07-22 at 10:34:36","Made available in DSpace on 2015-07-22T22:18:00Z (GMT). No. of bitstreams: 2 BRODSKY-THESIS-2015.pdf: 276971 bytes, checksum: d54f90ef04a134dc6957dd8e864e0ac4 (MD5) LICENSE.txt: 4211 bytes, checksum: 851557eaef69f22b4b2ec7122385c7c0 (MD5) Previous issue date: 2015-04-30"]},{"key":"dc:format","label":"Dc Format","values":["application/pdf"]},{"key":"dc:title","label":"Title","values":["Tyrosine hydroxylase immunoreactive fibers in the upper layers of the adolescent rat medial prefrontal cortex"]}]}],"canonical_facts":{"dc:creator":["Brodsky, Joseph Michael"],"dc:date":["2015-07-22T22:18:00Z","2015-05","2015-04-30","2015-5"],"dc:description":["Adolescence is an important period of maturation for the brain. In particular, the medial prefrontal cortex continues developing throughout adolescence and is responsible for a number of executive and cognitive functions. Innervation of the medial prefrontal cortex by the dopaminergic system contributes to some of these maturing behaviors and the dopaminergic system is implicated in mental illnesses. However, much previous work on medial prefrontal cortex development over adolescence has considered only one sex or has failed to capture timing of changes. Here, the development of tyrosine hydroxylase-immunoreactive axons, to indicate dopaminergic innervation, in the upper layers of the medial prefrontal cortex was examined in both sexes of Long-Evans rats during five ages from postnatal day 25 to 90. Tyrosine hydroxylase-immunoreactive axon density was found to increase over the course of adolescence, with the most marked increases being prepubertal in both males and females. No sex differences were identified. These results suggest a similar development, and thus similar susceptibility to disruption, of the dopaminergic system in the rat medial prefrontal cortex in both sexes.","Submission original under an indefinite embargo labeled 'Open Access'. The submission was exported from vireo on 2015-07-22 without embargo terms","The student, Joseph Brodsky, accepted the attached license on 2015-04-28 at 14:23.","The student, Joseph Brodsky, submitted this Thesis for approval on 2015-04-28 at 14:34.","This Thesis was approved for publication on 2015-04-30 at 11:21.","DSpace SAF Submission Ingestion Package generated from Vireo submission #8162 on 2015-07-22 at 10:34:36","Made available in DSpace on 2015-07-22T22:18:00Z (GMT). No. of bitstreams: 2 BRODSKY-THESIS-2015.pdf: 276971 bytes, checksum: d54f90ef04a134dc6957dd8e864e0ac4 (MD5) LICENSE.txt: 4211 bytes, checksum: 851557eaef69f22b4b2ec7122385c7c0 (MD5) Previous issue date: 2015-04-30"],"dc:format":["application/pdf"],"dc:identifier":["http://hdl.handle.net/2142/78531"],"dc:language":["en"],"dc:rights":["Copyright 2015 Joseph Brodsky"],"dc:subject":["Adolescence","Dopamine","prefrontal cortex","Rat","Sex Differences"],"dc:title":["Tyrosine hydroxylase immunoreactive fibers in the upper layers of the adolescent rat medial prefrontal cortex"],"dc:type":["text"],"thesis:degree_discipline":["Biology"],"thesis:degree_level":["Thesis"],"thesis:degree_name":["M.S."],"thesis:institution_name":["University of Illinois at Urbana-Champaign"]},"updated_at":"2026-07-22T22:26:11Z"}