{"id":{"repo_id":"uiuc","oai_identifier":"oai:www.ideals.illinois.edu:2142/77441"},"canonical_url":"https://search.dev.ndltd.org/etd/uiuc/oai:www.ideals.illinois.edu:2142/77441","repository":{"repo_id":"uiuc","name":"University of Illinois - Urbana-Champaign","base_url":"https://www.ideals.illinois.edu/oai-pmh"},"display":{"title":"Alterations in Vitamin a and Thyroid Hormone Metabolism in Anorexia Nervosa and Associated Disorders","abstract":"Vitamin A and thyroid hormone metabolism was investigated in subjects with anorexia nervosa. Subjects referred to the Eating Disorders Clinic were selected for the study if they had experienced a weight loss of (GREATERTHEQ) 15% of original body weight and had a basal metabolic rate (BMR) of (LESSTHEQ) -15%. Twenty-seven subjects were divided according to eating behavior, i.e., dietary restriction or bulimia; and by level of serum carotene. This subdivision resulted in three groups: Group I, dietary restricters, normal serum carotene; Group II, dietary restricters, elevated serum carotene; and Group III, bulimic, elevated serum carotene. All bulimic subjects fulfilling the initial criteria were hypercarotenemic. Data were compared to normal, healthy volunteers.","abstract_html":"Vitamin A and thyroid hormone metabolism was investigated in subjects with anorexia nervosa. Subjects referred to the Eating Disorders Clinic were selected for the study if they had experienced a weight loss of (GREATERTHEQ) 15% of original body weight and had a basal metabolic rate (BMR) of (LESSTHEQ) -15%. Twenty-seven subjects were divided according to eating behavior, i.e., dietary restriction or bulimia; and by level of serum carotene. This subdivision resulted in three groups: Group I, dietary restricters, normal serum carotene; Group II, dietary restricters, elevated serum carotene; and Group III, bulimic, elevated serum carotene. All bulimic subjects fulfilling the initial criteria were hypercarotenemic. Data were compared to normal, healthy volunteers.","abstract_has_math":false,"creators":["Curran, Joanne Marie"],"institution":"University of Illinois at Urbana-Champaign","degree_name":"Ph.D.","degree_level":"Dissertation","degree_discipline":"Food Science","degree_department":null,"school":null,"contributors":[],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2015,"date_issued":"2015-05-13T15:44:17Z","date_published":"2015-05-13T15:44:17Z","updated_at":"2026-07-22T22:26:10Z","subjects":["Health Sciences, Nutrition"],"languages":["eng"],"rights":[],"rights_urls":[],"identifier_entries":[{"key":"dc:identifier","label":"Identifier","values":["(UMI)AAI8302842"],"render_values":[{"text":"(UMI)AAI8302842","href":null,"code":true}]}]},"links":{"outbound_url":"http://hdl.handle.net/2142/77441","outbound_label":"Handle","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:creator","label":"Author","values":["Curran, Joanne Marie"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["2015-05-13T15:44:17Z","10000-01-01","1982"]},{"key":"dc:type","label":"Dc Type","values":["text"]},{"key":"thesis:degree_discipline","label":"Discipline","values":["Food Science"]},{"key":"thesis:degree_level","label":"Degree Level","values":["Dissertation"]},{"key":"thesis:degree_name","label":"Degree Name","values":["Ph.D."]},{"key":"thesis:institution_name","label":"Thesis Institution Name","values":["University of Illinois at Urbana-Champaign"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Health Sciences, Nutrition"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["eng"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["http://hdl.handle.net/2142/77441","(UMI)AAI8302842"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["Vitamin A and thyroid hormone metabolism was investigated in subjects with anorexia nervosa. Subjects referred to the Eating Disorders Clinic were selected for the study if they had experienced a weight loss of (GREATERTHEQ) 15% of original body weight and had a basal metabolic rate (BMR) of (LESSTHEQ) -15%. Twenty-seven subjects were divided according to eating behavior, i.e., dietary restriction or bulimia; and by level of serum carotene. This subdivision resulted in three groups: Group I, dietary restricters, normal serum carotene; Group II, dietary restricters, elevated serum carotene; and Group III, bulimic, elevated serum carotene. All bulimic subjects fulfilling the initial criteria were hypercarotenemic. Data were compared to normal, healthy volunteers.","Methods used in the analysis included: retinoid and carotenoid profiles by HPLC; retinol binding protein (RBP) by radial immuno-diffusion; thyroid hormones T(,4), T(,3) and rT(,3) by RIA; BMR by collection of basal respiratory gas and subsequent CO(,2) and O(,2) analysis.","Retinol and RBP were normal in all subjects. In Groups II and III, the hypercarotenemic groups, retinyl esters were significantly higher than in the non-hypercarotenemic group. The carotenoid profile revealed an elevation in retinoid active carotenoids, especially (beta)-carotene in hypercarotenemic groups, whereas in non-hypercarotenemic groups, non-vitamin A active lycopene was the major carotenoid. Thyroid hormones, T(,4) and T(,3), were significantly lower in the hypercarotenemic groups relative to control, whereas there was a trend toward elevated rT(,3) in all groups relative to control.","Diet was excluded from the etiology of hypercarotenemia since there was no difference in dietary intake between Groups I and II. In subjects with AN there is an adaptive change in metabolism conserving tissue stores of protein and energy, clearly evidenced by the lowered metabolic rate. Elevated retinyl esters and serum carotene reflect a decreased tissue need or an actual change in the cellular metabolism of vitamin A. Once elevated, retinyl esters may effect thyroid hormone metabolism. The elevated esters may effect binding of thyroxine to transport proteins, uptake of T(,4) by peripheral tissue, and/or subsequent conversion of T(,4) to T(,3). An elevated rT(,3) concentration suggests an alteration in the conversion of T(,4) under these conditions to the less metabolically active form.","The results clearly suggest that the alterations in vitamin A and thyroid hormone status of patients with AN are interrelated.","Made available in DSpace on 2015-05-13T15:44:17Z (GMT). No. of bitstreams: 2 license.txt: 4848 bytes, checksum: 96035ab3f5e1c23cc7138a224ce498bd (MD5) 8302842.PDF: 4457097 bytes, checksum: 4618863589de3c7482119487e2a743f7 (MD5) Previous issue date: 1982","Embargo set by: Seth Robbins for item 78652 Lift date: Forever Reason: Restricted to the U of I community idenfinitely during batch ingest of legacy ETDs","Restricted to the U of I community idenfinitely during batch ingest of legacy ETDs","U of I Only","134 p.","Thesis (Ph.D.)--University of Illinois at Urbana-Champaign, 1982."]},{"key":"dc:title","label":"Title","values":["Alterations in Vitamin a and Thyroid Hormone Metabolism in Anorexia Nervosa and Associated Disorders"]}]}],"canonical_facts":{"dc:creator":["Curran, Joanne Marie"],"dc:date":["2015-05-13T15:44:17Z","10000-01-01","1982"],"dc:description":["Vitamin A and thyroid hormone metabolism was investigated in subjects with anorexia nervosa. Subjects referred to the Eating Disorders Clinic were selected for the study if they had experienced a weight loss of (GREATERTHEQ) 15% of original body weight and had a basal metabolic rate (BMR) of (LESSTHEQ) -15%. Twenty-seven subjects were divided according to eating behavior, i.e., dietary restriction or bulimia; and by level of serum carotene. This subdivision resulted in three groups: Group I, dietary restricters, normal serum carotene; Group II, dietary restricters, elevated serum carotene; and Group III, bulimic, elevated serum carotene. All bulimic subjects fulfilling the initial criteria were hypercarotenemic. Data were compared to normal, healthy volunteers.","Methods used in the analysis included: retinoid and carotenoid profiles by HPLC; retinol binding protein (RBP) by radial immuno-diffusion; thyroid hormones T(,4), T(,3) and rT(,3) by RIA; BMR by collection of basal respiratory gas and subsequent CO(,2) and O(,2) analysis.","Retinol and RBP were normal in all subjects. In Groups II and III, the hypercarotenemic groups, retinyl esters were significantly higher than in the non-hypercarotenemic group. The carotenoid profile revealed an elevation in retinoid active carotenoids, especially (beta)-carotene in hypercarotenemic groups, whereas in non-hypercarotenemic groups, non-vitamin A active lycopene was the major carotenoid. Thyroid hormones, T(,4) and T(,3), were significantly lower in the hypercarotenemic groups relative to control, whereas there was a trend toward elevated rT(,3) in all groups relative to control.","Diet was excluded from the etiology of hypercarotenemia since there was no difference in dietary intake between Groups I and II. In subjects with AN there is an adaptive change in metabolism conserving tissue stores of protein and energy, clearly evidenced by the lowered metabolic rate. Elevated retinyl esters and serum carotene reflect a decreased tissue need or an actual change in the cellular metabolism of vitamin A. Once elevated, retinyl esters may effect thyroid hormone metabolism. The elevated esters may effect binding of thyroxine to transport proteins, uptake of T(,4) by peripheral tissue, and/or subsequent conversion of T(,4) to T(,3). An elevated rT(,3) concentration suggests an alteration in the conversion of T(,4) under these conditions to the less metabolically active form.","The results clearly suggest that the alterations in vitamin A and thyroid hormone status of patients with AN are interrelated.","Made available in DSpace on 2015-05-13T15:44:17Z (GMT). No. of bitstreams: 2 license.txt: 4848 bytes, checksum: 96035ab3f5e1c23cc7138a224ce498bd (MD5) 8302842.PDF: 4457097 bytes, checksum: 4618863589de3c7482119487e2a743f7 (MD5) Previous issue date: 1982","Embargo set by: Seth Robbins for item 78652 Lift date: Forever Reason: Restricted to the U of I community idenfinitely during batch ingest of legacy ETDs","Restricted to the U of I community idenfinitely during batch ingest of legacy ETDs","U of I Only","134 p.","Thesis (Ph.D.)--University of Illinois at Urbana-Champaign, 1982."],"dc:identifier":["http://hdl.handle.net/2142/77441","(UMI)AAI8302842"],"dc:language":["eng"],"dc:subject":["Health Sciences, Nutrition"],"dc:title":["Alterations in Vitamin a and Thyroid Hormone Metabolism in Anorexia Nervosa and Associated Disorders"],"dc:type":["text"],"thesis:degree_discipline":["Food Science"],"thesis:degree_level":["Dissertation"],"thesis:degree_name":["Ph.D."],"thesis:institution_name":["University of Illinois at Urbana-Champaign"]},"updated_at":"2026-07-22T22:26:10Z"}