Effects of nutrition, disease, and body condition score during the transition period on dairy cattle liver gene expression
type: CreativeWork
description: Transcriptomics and the introduction of bioinformatics approaches over the last couple of decades have had a large impact on the current revolutions in dairy welfare and the economics and structure of dairy industries. The etiology of disease e.g. endomeritits, metabolic dis-comforts and optimal calving BCS are major challenges for future advances in dairy cow management. The current research conducted five different studies to investigate the effects of nutrition, infection, disease and different calving BCS on cows’ hepatic transcriptomes and metabolic profiles using mRNA gene expression profiles, biochemical parameters, and the latest bioinformatics tools. The first study investigated the expression and regulatory mechanism of FGF21 under early postpartal ketosis, L-carnitine infusion, a prepartal high energy diet and inflammatory mediators. Ketosis increased the expression and serum level of FGF2; however, a high plasma concentration of carnitine decreased hepatic expression of FGF21. Prepartal high energy diet increased FGF21 expression and intra mammary LPS challenge further increased hepatic expression of FGF21. The decrease in hepatic KLB expression may suggest adipose as a target tissue for FGF21 in these cows. The findings from this study revealed that, like rodents and other mammals, bovine hepatic FGF21 is also regulated by changes in nutrition, metabolism, and inflammatory conditions through different mechanisms. This study will help to clarify the role of FGF21 as a nutrition adaptation factor in dairy cows (For details see chapter 2). The liver has a precise role in lipid metabolism; any change in dietary lipid supplementation can affect hepatic cell function through modulating the expression of an array of genes from different networks. The second project uncovered the change in phospholipids (PL) and triacylglycerol (TAG) LCFA profiles and expression of genes associated PPARα signaling, metabolism, growth, energy and immune responses in transitional…
abstract: Transcriptomics and the introduction of bioinformatics approaches over the last couple of decades have had a large impact on the current revolutions in dairy welfare and the economics and structure of dairy industries. The etiology of disease e.g. endomeritits, metabolic dis-comforts and optimal calving BCS are major challenges for future advances in dairy cow management. The current research conducted five different studies to investigate the effects of nutrition, infection, disease and different calving BCS on cows’ hepatic transcriptomes and metabolic profiles using mRNA gene expression profiles, biochemical parameters, and the latest bioinformatics tools. The first study investigated the expression and regulatory mechanism of FGF21 under early postpartal ketosis, L-carnitine infusion, a prepartal high energy diet and inflammatory mediators. Ketosis increased the expression and serum level of FGF2; however, a high plasma concentration of carnitine decreased hepatic expression of FGF21. Prepartal high energy diet increased FGF21 expression and intra mammary LPS challenge further increased hepatic expression of FGF21. The decrease in hepatic KLB expression may suggest adipose as a target tissue for FGF21 in these cows. The findings from this study revealed that, like rodents and other mammals, bovine hepatic FGF21 is also regulated by changes in nutrition, metabolism, and inflammatory conditions through different mechanisms. This study will help to clarify the role of FGF21 as a nutrition adaptation factor in dairy cows (For details see chapter 2). The liver has a precise role in lipid metabolism; any change in dietary lipid supplementation can affect hepatic cell function through modulating the expression of an array of genes from different networks. The second project uncovered the change in phospholipids (PL) and triacylglycerol (TAG) LCFA profiles and expression of genes associated PPARα signaling, metabolism, growth, energy and immune responses in transitional…
author: Akbar, Haji
language: en
keywords: dairy cows, diet, uterine infection, body condition score (BCS), liver transcriptomes
date published: 2015-01-21T19:55:09Z
date modified: 2026-07-22T22:26:07Z
provider: University of Illinois - Urbana-Champaign
publisher: Networked Digital Library of Theses and Dissertations
type: WebPage
source organization: University of Illinois at Urbana-Champaign

PropertyValue
property ID: Handle
value: http://hdl.handle.net/2142/72974