Synthesis and Complexation Studies of Heterocyclic Compounds With Two or Three Contiguous Hydrogen Bonding Sites
The design and synthesis of heterocyclic compounds with two or three adjacent hydrogen bonding sites is described. A general synthetic methodology was developed to produce 5-substituted anthyridine analogs. These compounds exhibited increased stability over the unsubstituted anthyridines. A novel hydrogen bond donor-donor-acceptor (DDA) unit was synthesized to mimic the hydrogen bond functionality of guanosine. A guanosine receptor was developed to ascertain the negative steric interactions inherent in Hamilton's guanosine receptor.
University of Illinois - Urbana-Champaign
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University of Illinois at Urbana-Champaign