{"id":{"repo_id":"uiuc","oai_identifier":"oai:www.ideals.illinois.edu:2142/72296"},"canonical_url":"https://search.dev.ndltd.org/etd/uiuc/oai:www.ideals.illinois.edu:2142/72296","repository":{"repo_id":"uiuc","name":"University of Illinois - Urbana-Champaign","base_url":"https://www.ideals.illinois.edu/oai-pmh"},"display":{"title":"Mechanistic Aspects of Enantioselective Complexation","abstract":"The effect of differential penetration (&quot;intercalation&quot;) of enantiomeric analytes between the strands of synthetic, brush-type liquid chromatographic chiral stationary phases (CSPs) has been investigated. The design and evaluation of a new family of $\\pi$-basic CSPs which utilize these intercalative effects to enhance enantioselectivity is discussed. These CSPs, designed from mechanistic considerations, are useful in the separation of the enantiomers of a number of chiral amines, amino acid esters and amides, amino alcohols and alcohols. Solution-state NMR evidence, including intermolecular nuclear Overhauser enhancements, and X-ray crystallographic data provide support for the primary chiral recognition mechanism.","abstract_html":"The effect of differential penetration (&amp;quot;intercalation&amp;quot;) of enantiomeric analytes between the strands of synthetic, brush-type liquid chromatographic chiral stationary phases (CSPs) has been investigated. The design and evaluation of a new family of <span class=\"etd-inline-math\">&pi;</span>-basic CSPs which utilize these intercalative effects to enhance enantioselectivity is discussed. These CSPs, designed from mechanistic considerations, are useful in the separation of the enantiomers of a number of chiral amines, amino acid esters and amides, amino alcohols and alcohols. Solution-state NMR evidence, including intermolecular nuclear Overhauser enhancements, and X-ray crystallographic data provide support for the primary chiral recognition mechanism.","abstract_has_math":true,"creators":["Murray, Patrick Gerard"],"institution":"University of Illinois at Urbana-Champaign","degree_name":"Ph.D.","degree_level":"Dissertation","degree_discipline":"Chemistry","degree_department":null,"school":null,"contributors":["Pirkle, William H."],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2014,"date_issued":"2014-12-17T21:29:14Z","date_published":"2014-12-17T21:29:14Z","updated_at":"2026-07-22T22:26:06Z","subjects":["Chemistry, Analytical","Chemistry, Organic"],"languages":[],"rights":[],"rights_urls":[],"identifier_entries":[{"key":"dc:identifier","label":"Identifier","values":["(UMI)AAI9503279"],"render_values":[{"text":"(UMI)AAI9503279","href":null,"code":true}]}]},"links":{"outbound_url":"http://hdl.handle.net/2142/72296","outbound_label":"Handle","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["Pirkle, William H."]},{"key":"dc:creator","label":"Author","values":["Murray, Patrick Gerard"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["2014-12-17T21:29:14Z","10000-01-01","1994"]},{"key":"dc:type","label":"Dc Type","values":["text"]},{"key":"thesis:degree_discipline","label":"Discipline","values":["Chemistry"]},{"key":"thesis:degree_level","label":"Degree Level","values":["Dissertation"]},{"key":"thesis:degree_name","label":"Degree Name","values":["Ph.D."]},{"key":"thesis:institution_name","label":"Thesis Institution Name","values":["University of Illinois at Urbana-Champaign"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Chemistry, Analytical","Chemistry, Organic"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["http://hdl.handle.net/2142/72296","(UMI)AAI9503279"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["The effect of differential penetration (&quot;intercalation&quot;) of enantiomeric analytes between the strands of synthetic, brush-type liquid chromatographic chiral stationary phases (CSPs) has been investigated. The design and evaluation of a new family of $\\pi$-basic CSPs which utilize these intercalative effects to enhance enantioselectivity is discussed. These CSPs, designed from mechanistic considerations, are useful in the separation of the enantiomers of a number of chiral amines, amino acid esters and amides, amino alcohols and alcohols. Solution-state NMR evidence, including intermolecular nuclear Overhauser enhancements, and X-ray crystallographic data provide support for the primary chiral recognition mechanism.","Made available in DSpace on 2014-12-17T21:29:14Z (GMT). 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The design and evaluation of a new family of $\\pi$-basic CSPs which utilize these intercalative effects to enhance enantioselectivity is discussed. These CSPs, designed from mechanistic considerations, are useful in the separation of the enantiomers of a number of chiral amines, amino acid esters and amides, amino alcohols and alcohols. Solution-state NMR evidence, including intermolecular nuclear Overhauser enhancements, and X-ray crystallographic data provide support for the primary chiral recognition mechanism.","Made available in DSpace on 2014-12-17T21:29:14Z (GMT). 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