{"id":{"repo_id":"uiuc","oai_identifier":"oai:www.ideals.illinois.edu:2142/71451"},"canonical_url":"https://search.dev.ndltd.org/etd/uiuc/oai:www.ideals.illinois.edu:2142/71451","repository":{"repo_id":"uiuc","name":"University of Illinois - Urbana-Champaign","base_url":"https://www.ideals.illinois.edu/oai-pmh"},"display":{"title":"Analysis of Neural Contributions to Ultradian Oscillations of Blood Pressure and Heart Rate in Dogs","abstract":"A remarkably stable and accurate FM telemetry system was used to obtain long-term recordings of mean arterial pressure (MAP) and heart rate (HR) from unanesthetized, free-running dogs. These data were analyzed for their harmonic content by applying standard Fast Fourier Transform (FFT) time series analysis techniques. The FFT coefficients were used to calculate power spectral density functions from which the primary oscillatory frequency and the associated power of the primary frequency were determined. Initial studies revealed coherent ultradian oscillations of MAP and HR with a period between 1-2 hours (hr). These oscillations were found to be in phase. The significant decrease in power of these oscillations following the administration of clonidine, a centrally acting alpha$\\sb2$ agonist, suggested that the central nervous system was involved in the genesis of these rhythms. Peripheral ganglionic blockade induced by hexamethonium bromide (10mg/kg/hr) significantly reduced the power of both MAP and HR oscillations, demonstrating the contribution of the autonomic efferent nerves. Atropine sulfate (2mg/hr) potentiated the power of both MAP and HR oscillations (P $<$ 0.06) suggesting that vagal efferent nerves are not mediating either HR or MAP oscillations, and may actually attenuate them. Metoprolol (200mg/day; b.i.d. for 5 days), a beta$\\sb1$ antagonist, significantly decreased the power of HR and MAP oscillations. Prazosin (50ug/kg/hr), an alpha$\\sb1$ antagonist, significantly decreased the power of MAP oscillations but increased the power of HR oscillations. These latter two series suggest that sympathetic innervation of both the vasculature and the heart are involved in expressing these rhythms.","abstract_html":"A remarkably stable and accurate FM telemetry system was used to obtain long-term recordings of mean arterial pressure (MAP) and heart rate (HR) from unanesthetized, free-running dogs. These data were analyzed for their harmonic content by applying standard Fast Fourier Transform (FFT) time series analysis techniques. The FFT coefficients were used to calculate power spectral density functions from which the primary oscillatory frequency and the associated power of the primary frequency were determined. Initial studies revealed coherent ultradian oscillations of MAP and HR with a period between 1-2 hours (hr). These oscillations were found to be in phase. The significant decrease in power of these oscillations following the administration of clonidine, a centrally acting alpha$\\sb2$ agonist, suggested that the central nervous system was involved in the genesis of these rhythms. Peripheral ganglionic blockade induced by hexamethonium bromide (10mg/kg/hr) significantly reduced the power of both MAP and HR oscillations, demonstrating the contribution of the autonomic efferent nerves. Atropine sulfate (2mg/hr) potentiated the power of both MAP and HR oscillations (P $<$ 0.06) suggesting that vagal efferent nerves are not mediating either HR or MAP oscillations, and may actually attenuate them. Metoprolol (200mg/day; b.i.d. for 5 days), a beta$\\sb1$ antagonist, significantly decreased the power of HR and MAP oscillations. Prazosin (50ug/kg/hr), an alpha$\\sb1$ antagonist, significantly decreased the power of MAP oscillations but increased the power of HR oscillations. These latter two series suggest that sympathetic innervation of both the vasculature and the heart are involved in expressing these rhythms.","abstract_has_math":true,"creators":["Broten, Theodore Paul"],"institution":"University of Illinois at Urbana-Champaign","degree_name":"Ph.D.","degree_level":"Dissertation","degree_discipline":"Physiology","degree_department":null,"school":null,"contributors":["Zehr, John E."],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2014,"date_issued":"2014-12-16T06:45:52Z","date_published":"2014-12-16T06:45:52Z","updated_at":"2026-07-22T22:26:04Z","subjects":["Biology, Animal Physiology"],"languages":[],"rights":[],"rights_urls":[],"identifier_entries":[{"key":"dc:identifier","label":"Identifier","values":["(UMI)AAI8802987"],"render_values":[{"text":"(UMI)AAI8802987","href":null,"code":true}]}]},"links":{"outbound_url":"http://hdl.handle.net/2142/71451","outbound_label":"Handle","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["Zehr, John E."]},{"key":"dc:creator","label":"Author","values":["Broten, Theodore Paul"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["2014-12-16T06:45:52Z","10000-01-01","1987"]},{"key":"dc:type","label":"Dc Type","values":["text"]},{"key":"thesis:degree_discipline","label":"Discipline","values":["Physiology"]},{"key":"thesis:degree_level","label":"Degree Level","values":["Dissertation"]},{"key":"thesis:degree_name","label":"Degree Name","values":["Ph.D."]},{"key":"thesis:institution_name","label":"Thesis Institution Name","values":["University of Illinois at Urbana-Champaign"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Biology, Animal Physiology"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["http://hdl.handle.net/2142/71451","(UMI)AAI8802987"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["A remarkably stable and accurate FM telemetry system was used to obtain long-term recordings of mean arterial pressure (MAP) and heart rate (HR) from unanesthetized, free-running dogs. These data were analyzed for their harmonic content by applying standard Fast Fourier Transform (FFT) time series analysis techniques. The FFT coefficients were used to calculate power spectral density functions from which the primary oscillatory frequency and the associated power of the primary frequency were determined. Initial studies revealed coherent ultradian oscillations of MAP and HR with a period between 1-2 hours (hr). These oscillations were found to be in phase. The significant decrease in power of these oscillations following the administration of clonidine, a centrally acting alpha$\\sb2$ agonist, suggested that the central nervous system was involved in the genesis of these rhythms. Peripheral ganglionic blockade induced by hexamethonium bromide (10mg/kg/hr) significantly reduced the power of both MAP and HR oscillations, demonstrating the contribution of the autonomic efferent nerves. Atropine sulfate (2mg/hr) potentiated the power of both MAP and HR oscillations (P $<$ 0.06) suggesting that vagal efferent nerves are not mediating either HR or MAP oscillations, and may actually attenuate them. Metoprolol (200mg/day; b.i.d. for 5 days), a beta$\\sb1$ antagonist, significantly decreased the power of HR and MAP oscillations. Prazosin (50ug/kg/hr), an alpha$\\sb1$ antagonist, significantly decreased the power of MAP oscillations but increased the power of HR oscillations. These latter two series suggest that sympathetic innervation of both the vasculature and the heart are involved in expressing these rhythms.","The role of the arterial baroreflexes in modulating these rhythms was also examined. Data from carotid sinus denervation, cervical aortic denervation, and combined sino-cervical aortic denervation suggest that afferent input from the baroreceptors is not necessary for the genesis of these ultradian rhythms. The carotid sinus baroreflex alone significantly buffers the magnitude of the MAP oscillations but does not affect the HR oscillations. These data also suggest that there are two functional ultradian oscillators, one for HR and one for MAP.","Lastly, the existence of these ultradian rhythms as well as other fluctuations in MAP were shown to significantly affect sampling paradigms for the estimation of 24 hour MAP. Statistical parameters describing the accuracy of short-term measurements as estimators of 24 hour MAP were described.","Made available in DSpace on 2014-12-16T06:45:52Z (GMT). No. of bitstreams: 1 8802987.pdf: 4803561 bytes, checksum: 98d70da251cd1ba076f06302f7ae30fc (MD5) Previous issue date: 1987","Embargo set by: Seth Robbins for item 71617 Lift date: Forever Reason: Restricted to the U of I community idenfinitely during batch ingest of legacy ETDs","Restricted to the U of I community idenfinitely during batch ingest of legacy ETDs","U of I Only","177 p.","Thesis (Ph.D.)--University of Illinois at Urbana-Champaign, 1987."]},{"key":"dc:title","label":"Title","values":["Analysis of Neural Contributions to Ultradian Oscillations of Blood Pressure and Heart Rate in Dogs"]}]}],"canonical_facts":{"dc:contributor":["Zehr, John E."],"dc:creator":["Broten, Theodore Paul"],"dc:date":["2014-12-16T06:45:52Z","10000-01-01","1987"],"dc:description":["A remarkably stable and accurate FM telemetry system was used to obtain long-term recordings of mean arterial pressure (MAP) and heart rate (HR) from unanesthetized, free-running dogs. These data were analyzed for their harmonic content by applying standard Fast Fourier Transform (FFT) time series analysis techniques. The FFT coefficients were used to calculate power spectral density functions from which the primary oscillatory frequency and the associated power of the primary frequency were determined. Initial studies revealed coherent ultradian oscillations of MAP and HR with a period between 1-2 hours (hr). These oscillations were found to be in phase. The significant decrease in power of these oscillations following the administration of clonidine, a centrally acting alpha$\\sb2$ agonist, suggested that the central nervous system was involved in the genesis of these rhythms. Peripheral ganglionic blockade induced by hexamethonium bromide (10mg/kg/hr) significantly reduced the power of both MAP and HR oscillations, demonstrating the contribution of the autonomic efferent nerves. Atropine sulfate (2mg/hr) potentiated the power of both MAP and HR oscillations (P $<$ 0.06) suggesting that vagal efferent nerves are not mediating either HR or MAP oscillations, and may actually attenuate them. Metoprolol (200mg/day; b.i.d. for 5 days), a beta$\\sb1$ antagonist, significantly decreased the power of HR and MAP oscillations. Prazosin (50ug/kg/hr), an alpha$\\sb1$ antagonist, significantly decreased the power of MAP oscillations but increased the power of HR oscillations. These latter two series suggest that sympathetic innervation of both the vasculature and the heart are involved in expressing these rhythms.","The role of the arterial baroreflexes in modulating these rhythms was also examined. Data from carotid sinus denervation, cervical aortic denervation, and combined sino-cervical aortic denervation suggest that afferent input from the baroreceptors is not necessary for the genesis of these ultradian rhythms. The carotid sinus baroreflex alone significantly buffers the magnitude of the MAP oscillations but does not affect the HR oscillations. These data also suggest that there are two functional ultradian oscillators, one for HR and one for MAP.","Lastly, the existence of these ultradian rhythms as well as other fluctuations in MAP were shown to significantly affect sampling paradigms for the estimation of 24 hour MAP. Statistical parameters describing the accuracy of short-term measurements as estimators of 24 hour MAP were described.","Made available in DSpace on 2014-12-16T06:45:52Z (GMT). No. of bitstreams: 1 8802987.pdf: 4803561 bytes, checksum: 98d70da251cd1ba076f06302f7ae30fc (MD5) Previous issue date: 1987","Embargo set by: Seth Robbins for item 71617 Lift date: Forever Reason: Restricted to the U of I community idenfinitely during batch ingest of legacy ETDs","Restricted to the U of I community idenfinitely during batch ingest of legacy ETDs","U of I Only","177 p.","Thesis (Ph.D.)--University of Illinois at Urbana-Champaign, 1987."],"dc:identifier":["http://hdl.handle.net/2142/71451","(UMI)AAI8802987"],"dc:subject":["Biology, Animal Physiology"],"dc:title":["Analysis of Neural Contributions to Ultradian Oscillations of Blood Pressure and Heart Rate in Dogs"],"dc:type":["text"],"thesis:degree_discipline":["Physiology"],"thesis:degree_level":["Dissertation"],"thesis:degree_name":["Ph.D."],"thesis:institution_name":["University of Illinois at Urbana-Champaign"]},"updated_at":"2026-07-22T22:26:04Z"}