{"id":{"repo_id":"uiuc","oai_identifier":"oai:www.ideals.illinois.edu:2142/71428"},"canonical_url":"https://search.dev.ndltd.org/etd/uiuc/oai:www.ideals.illinois.edu:2142/71428","repository":{"repo_id":"uiuc","name":"University of Illinois - Urbana-Champaign","base_url":"https://www.ideals.illinois.edu/oai-pmh"},"display":{"title":"Involvement of Beta-Endorphin in Thermoregulation of Rabbits, Oryctolagus Cuniculus","abstract":"164 p.","abstract_html":"164 p.","abstract_has_math":false,"creators":["Rezvani-Bidgoli, Amir Hosein"],"institution":"University of Illinois at Urbana-Champaign","degree_name":"Ph.D.","degree_level":"Dissertation","degree_discipline":"Physiology","degree_department":null,"school":null,"contributors":[],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2014,"date_issued":"2014-12-16T06:45:44Z","date_published":"2014-12-16T06:45:44Z","updated_at":"2026-07-22T22:26:04Z","subjects":["Biology, Animal Physiology"],"languages":[],"rights":[],"rights_urls":[],"identifier_entries":[{"key":"dc:identifier","label":"Identifier","values":["(UMI)AAI8410030"],"render_values":[{"text":"(UMI)AAI8410030","href":null,"code":true}]}]},"links":{"outbound_url":"http://hdl.handle.net/2142/71428","outbound_label":"Handle","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:creator","label":"Author","values":["Rezvani-Bidgoli, Amir Hosein"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["2014-12-16T06:45:44Z","10000-01-01","1983"]},{"key":"dc:type","label":"Dc Type","values":["text"]},{"key":"thesis:degree_discipline","label":"Discipline","values":["Physiology"]},{"key":"thesis:degree_level","label":"Degree Level","values":["Dissertation"]},{"key":"thesis:degree_name","label":"Degree Name","values":["Ph.D."]},{"key":"thesis:institution_name","label":"Thesis Institution Name","values":["University of Illinois at Urbana-Champaign"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Biology, Animal Physiology"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["http://hdl.handle.net/2142/71428","(UMI)AAI8410030"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["164 p.","Thesis (Ph.D.)--University of Illinois at Urbana-Champaign, 1983.","Certain neuropeptides alter the thermoregulatory responses and behaviors of the animals by affecting the preoptic/anterior hypothalamus (PO/AH). The primary objective of this investigation is to study the effect of beta-endorphin ((beta)-E) on regulation of body temperature.","Male New Zealand White rabbits, Oryctolagus cuniculus, were stereotaxically implanted with a guide tube above the PO/AH for the injection of (beta)-E, naloxone, sodium salicylate, or physiological saline. PO/AH and ear temperature, oxygen consumption, and evaporative heat loss (EHL) were recorded before and after injection of first saline and then (beta)-E, naloxone, or sodium salicylate at ambient temperatures (T(,a)) of 2-31(DEGREES)C. A 5-(mu)g injection of (beta)-E promoted a rapid reduction in ear temperature followed by a prolonged rise in PO/AH (body) temperature (T(,br)). Preinjection with an isovolumetric amount of naloxone, inhibited the thermoregulatory effects of (beta)-E. The (beta)-E- induced rise in body temperature was directly correlated with T(,a). (beta)-E had no effect on oxygen consumption. (beta)-E inhibited EHL at T(,a)'s of 27 and 31 but not at 5(DEGREES)C. The (beta)-E-induced rise in body temperature was not antagonized by preinjection of sodium salicylate.","In another series of experiments, T(,ear) and T(,br) were recorded in control and (beta)-E pretreated rabbits while radiant heat was applied to the dorsal skin. In control the T(,ear) underwent a rapid increase during back heating. Following (beta)-E administration there was a large reduction in responsiveness of T(,ear) to radiant heat. The time to respond to radiant heat for (beta)-E pretreated rabbits was significantly longer than that for control rabbits. The interaction between norepinephrine (NE) and (beta)-E in regulation of body temperature was examined. The data indicate that (beta)-E-hyperthermia and NE-hyperthermia are mediated through separate pathways. The thermal response to a range of doses of (beta)-endorphin produced a linear dose-response curve.","In conclusion, (beta)-E microinjected into the rabbit induces a reduction in passage of temperature information from cutaneous thermal receptors to the PO/AH and the (beta)-E-induced reduction in sensitivity of the vasomotor system to radiant heat may account for the effectiveness of this opioid peptide in promoting hyperthermia in the rabbit. The (beta)-endorphinergic system may have a natural role in thermoregulatory responses during physical and psychological stress.","Made available in DSpace on 2014-12-16T06:45:44Z (GMT). No. of bitstreams: 1 8410030.pdf: 5001839 bytes, checksum: bed24900d825f601b1cd32346f5f711e (MD5) Previous issue date: 1983","Embargo set by: Seth Robbins for item 71594 Lift date: Forever Reason: Restricted to the U of I community idenfinitely during batch ingest of legacy ETDs","Restricted to the U of I community idenfinitely during batch ingest of legacy ETDs","U of I Only"]},{"key":"dc:title","label":"Title","values":["Involvement of Beta-Endorphin in Thermoregulation of Rabbits, Oryctolagus Cuniculus"]}]}],"canonical_facts":{"dc:creator":["Rezvani-Bidgoli, Amir Hosein"],"dc:date":["2014-12-16T06:45:44Z","10000-01-01","1983"],"dc:description":["164 p.","Thesis (Ph.D.)--University of Illinois at Urbana-Champaign, 1983.","Certain neuropeptides alter the thermoregulatory responses and behaviors of the animals by affecting the preoptic/anterior hypothalamus (PO/AH). The primary objective of this investigation is to study the effect of beta-endorphin ((beta)-E) on regulation of body temperature.","Male New Zealand White rabbits, Oryctolagus cuniculus, were stereotaxically implanted with a guide tube above the PO/AH for the injection of (beta)-E, naloxone, sodium salicylate, or physiological saline. PO/AH and ear temperature, oxygen consumption, and evaporative heat loss (EHL) were recorded before and after injection of first saline and then (beta)-E, naloxone, or sodium salicylate at ambient temperatures (T(,a)) of 2-31(DEGREES)C. A 5-(mu)g injection of (beta)-E promoted a rapid reduction in ear temperature followed by a prolonged rise in PO/AH (body) temperature (T(,br)). Preinjection with an isovolumetric amount of naloxone, inhibited the thermoregulatory effects of (beta)-E. The (beta)-E- induced rise in body temperature was directly correlated with T(,a). (beta)-E had no effect on oxygen consumption. (beta)-E inhibited EHL at T(,a)'s of 27 and 31 but not at 5(DEGREES)C. The (beta)-E-induced rise in body temperature was not antagonized by preinjection of sodium salicylate.","In another series of experiments, T(,ear) and T(,br) were recorded in control and (beta)-E pretreated rabbits while radiant heat was applied to the dorsal skin. In control the T(,ear) underwent a rapid increase during back heating. Following (beta)-E administration there was a large reduction in responsiveness of T(,ear) to radiant heat. The time to respond to radiant heat for (beta)-E pretreated rabbits was significantly longer than that for control rabbits. The interaction between norepinephrine (NE) and (beta)-E in regulation of body temperature was examined. The data indicate that (beta)-E-hyperthermia and NE-hyperthermia are mediated through separate pathways. The thermal response to a range of doses of (beta)-endorphin produced a linear dose-response curve.","In conclusion, (beta)-E microinjected into the rabbit induces a reduction in passage of temperature information from cutaneous thermal receptors to the PO/AH and the (beta)-E-induced reduction in sensitivity of the vasomotor system to radiant heat may account for the effectiveness of this opioid peptide in promoting hyperthermia in the rabbit. The (beta)-endorphinergic system may have a natural role in thermoregulatory responses during physical and psychological stress.","Made available in DSpace on 2014-12-16T06:45:44Z (GMT). No. of bitstreams: 1 8410030.pdf: 5001839 bytes, checksum: bed24900d825f601b1cd32346f5f711e (MD5) Previous issue date: 1983","Embargo set by: Seth Robbins for item 71594 Lift date: Forever Reason: Restricted to the U of I community idenfinitely during batch ingest of legacy ETDs","Restricted to the U of I community idenfinitely during batch ingest of legacy ETDs","U of I Only"],"dc:identifier":["http://hdl.handle.net/2142/71428","(UMI)AAI8410030"],"dc:subject":["Biology, Animal Physiology"],"dc:title":["Involvement of Beta-Endorphin in Thermoregulation of Rabbits, Oryctolagus Cuniculus"],"dc:type":["text"],"thesis:degree_discipline":["Physiology"],"thesis:degree_level":["Dissertation"],"thesis:degree_name":["Ph.D."],"thesis:institution_name":["University of Illinois at Urbana-Champaign"]},"updated_at":"2026-07-22T22:26:04Z"}