Systemic and Regional Distribution of Blood Flow During T-2 Toxin Induced Shock in Swine (Microspheres)
Three groups of swine (6 per group) were used to assess alterations in blood flow induced by single doses of T-2 toxin infused into the pulmonary artery. Two groups were dosed at 0.6 or 2.4 mg/kg T-2 toxin and the third group served as a vehicle control (70% ethanol). Organ blood flow was determined at 0 hour (predosing) and at 90 minute intervals for 6 hours, using the radiolabeled microsphere technique. Hemodynamic parameters were obtained at the same time points.
University of Illinois - Urbana-Champaign
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University of Illinois at Urbana-Champaign