{"id":{"repo_id":"uiuc","oai_identifier":"oai:www.ideals.illinois.edu:2142/71337"},"canonical_url":"https://search.dev.ndltd.org/etd/uiuc/oai:www.ideals.illinois.edu:2142/71337","repository":{"repo_id":"uiuc","name":"University of Illinois - Urbana-Champaign","base_url":"https://www.ideals.illinois.edu/oai-pmh"},"display":{"title":"T2 Mycotoxicosis in Swine Following Topical Application, Intravascular Administration and Inhalation Exposure","abstract":"Studies were conducted to characterize the clinical signs, pathologic changes and pulmonary and systemic immunity of T-2 toxicosis in swine following a single, topical (15 mg/kg), intravascular (0.6 to 5.4 mg/kg) or inhalation (8 or 9 mg/kg; 20 to 30 percent retention) exposure.","abstract_html":"Studies were conducted to characterize the clinical signs, pathologic changes and pulmonary and systemic immunity of T-2 toxicosis in swine following a single, topical (15 mg/kg), intravascular (0.6 to 5.4 mg/kg) or inhalation (8 or 9 mg/kg; 20 to 30 percent retention) exposure.","abstract_has_math":false,"creators":["Pang, Fei Victor"],"institution":"University of Illinois at Urbana-Champaign","degree_name":"Ph.D.","degree_level":"Dissertation","degree_discipline":"Veterinary Medical Science","degree_department":null,"school":null,"contributors":[],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2014,"date_issued":"2014-12-16T06:35:45Z","date_published":"2014-12-16T06:35:45Z","updated_at":"2026-07-22T22:26:04Z","subjects":["Biology, Veterinary Science"],"languages":[],"rights":[],"rights_urls":[],"identifier_entries":[{"key":"dc:identifier","label":"Identifier","values":["(UMI)AAI8623386"],"render_values":[{"text":"(UMI)AAI8623386","href":null,"code":true}]}]},"links":{"outbound_url":"http://hdl.handle.net/2142/71337","outbound_label":"Handle","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:creator","label":"Author","values":["Pang, Fei Victor"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["2014-12-16T06:35:45Z","10000-01-01","1986"]},{"key":"dc:type","label":"Dc Type","values":["text"]},{"key":"thesis:degree_discipline","label":"Discipline","values":["Veterinary Medical Science"]},{"key":"thesis:degree_level","label":"Degree Level","values":["Dissertation"]},{"key":"thesis:degree_name","label":"Degree Name","values":["Ph.D."]},{"key":"thesis:institution_name","label":"Thesis Institution Name","values":["University of Illinois at Urbana-Champaign"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Biology, Veterinary Science"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["http://hdl.handle.net/2142/71337","(UMI)AAI8623386"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["Studies were conducted to characterize the clinical signs, pathologic changes and pulmonary and systemic immunity of T-2 toxicosis in swine following a single, topical (15 mg/kg), intravascular (0.6 to 5.4 mg/kg) or inhalation (8 or 9 mg/kg; 20 to 30 percent retention) exposure.","Topical T-2 application caused severe dermal injury and adverse systemic effects, including anorexia, posterior weakness, persistent fever and reduced body weight gain; neutrophilia, decreased serum glucose, albumin and alkaline phosphatase activity, and increased serum globulin; lower cell-mediated immune responses; and minimal pancreatic and lymphoid necrosis. Significant amounts of T-2 toxin and its metabolites were detected in dosed areas of the skin and subcutaneous fat. Thus, the skin and subcutaneous fat may act as a depot and site of metabolism for T-2 toxin from which the toxin and its metabolites are slowly absorbed.","Intravascular injection of T-2 toxin caused degeneration and necrosis of lymphoid tissues, gastrointestinal mucosa, pancreas, myocardium, bone marrow, adrenal cortex and kidney. There was a dose-dependent increase in lesion severity except for the pancreatic changes. The lymphoid and gastrointestinal necrosis of T-2 treated pigs are similar to those of other species. The pancreas and heart should also be considered as target organs in the pig.","Inhalation exposure to T-2 toxin caused vomiting, cyanosis, anorexia, lethargy, lateral recumbency and even death. Elevated rectal temperature and poor body weight gain; neutrophilia, lymphopenia, decreased serum protein, and a transient increase followed by a prominent decrease in serum alkaline phosphatase activity; lower cell-mediated and humoral systemic immune responses; markedly reduced phagocytic ability of alveolar macrophages and mitogen-induced blasto-genesis of pulmonary lymphocytes; interstitial pneumonia, and necrosis of lymphoid tissues, gastrointestinal mucosa, pancreas and myocardium were also found. The majority of these alterations occurred early after dosing and were transient. In many respects, the effects of T-2 toxin on pigs dosed by inhalation are similar those following intravascular injection.","Made available in DSpace on 2014-12-16T06:35:45Z (GMT). No. of bitstreams: 1 8623386.pdf: 10987188 bytes, checksum: 8baef75493692dcee31fdb44a7f86785 (MD5) Previous issue date: 1986","Embargo set by: Seth Robbins for item 71503 Lift date: Forever Reason: Restricted to the U of I community idenfinitely during batch ingest of legacy ETDs","Restricted to the U of I community idenfinitely during batch ingest of legacy ETDs","U of I Only","308 p.","Thesis (Ph.D.)--University of Illinois at Urbana-Champaign, 1986."]},{"key":"dc:title","label":"Title","values":["T2 Mycotoxicosis in Swine Following Topical Application, Intravascular Administration and Inhalation Exposure"]}]}],"canonical_facts":{"dc:creator":["Pang, Fei Victor"],"dc:date":["2014-12-16T06:35:45Z","10000-01-01","1986"],"dc:description":["Studies were conducted to characterize the clinical signs, pathologic changes and pulmonary and systemic immunity of T-2 toxicosis in swine following a single, topical (15 mg/kg), intravascular (0.6 to 5.4 mg/kg) or inhalation (8 or 9 mg/kg; 20 to 30 percent retention) exposure.","Topical T-2 application caused severe dermal injury and adverse systemic effects, including anorexia, posterior weakness, persistent fever and reduced body weight gain; neutrophilia, decreased serum glucose, albumin and alkaline phosphatase activity, and increased serum globulin; lower cell-mediated immune responses; and minimal pancreatic and lymphoid necrosis. Significant amounts of T-2 toxin and its metabolites were detected in dosed areas of the skin and subcutaneous fat. Thus, the skin and subcutaneous fat may act as a depot and site of metabolism for T-2 toxin from which the toxin and its metabolites are slowly absorbed.","Intravascular injection of T-2 toxin caused degeneration and necrosis of lymphoid tissues, gastrointestinal mucosa, pancreas, myocardium, bone marrow, adrenal cortex and kidney. There was a dose-dependent increase in lesion severity except for the pancreatic changes. The lymphoid and gastrointestinal necrosis of T-2 treated pigs are similar to those of other species. The pancreas and heart should also be considered as target organs in the pig.","Inhalation exposure to T-2 toxin caused vomiting, cyanosis, anorexia, lethargy, lateral recumbency and even death. Elevated rectal temperature and poor body weight gain; neutrophilia, lymphopenia, decreased serum protein, and a transient increase followed by a prominent decrease in serum alkaline phosphatase activity; lower cell-mediated and humoral systemic immune responses; markedly reduced phagocytic ability of alveolar macrophages and mitogen-induced blasto-genesis of pulmonary lymphocytes; interstitial pneumonia, and necrosis of lymphoid tissues, gastrointestinal mucosa, pancreas and myocardium were also found. The majority of these alterations occurred early after dosing and were transient. In many respects, the effects of T-2 toxin on pigs dosed by inhalation are similar those following intravascular injection.","Made available in DSpace on 2014-12-16T06:35:45Z (GMT). No. of bitstreams: 1 8623386.pdf: 10987188 bytes, checksum: 8baef75493692dcee31fdb44a7f86785 (MD5) Previous issue date: 1986","Embargo set by: Seth Robbins for item 71503 Lift date: Forever Reason: Restricted to the U of I community idenfinitely during batch ingest of legacy ETDs","Restricted to the U of I community idenfinitely during batch ingest of legacy ETDs","U of I Only","308 p.","Thesis (Ph.D.)--University of Illinois at Urbana-Champaign, 1986."],"dc:identifier":["http://hdl.handle.net/2142/71337","(UMI)AAI8623386"],"dc:subject":["Biology, Veterinary Science"],"dc:title":["T2 Mycotoxicosis in Swine Following Topical Application, Intravascular Administration and Inhalation Exposure"],"dc:type":["text"],"thesis:degree_discipline":["Veterinary Medical Science"],"thesis:degree_level":["Dissertation"],"thesis:degree_name":["Ph.D."],"thesis:institution_name":["University of Illinois at Urbana-Champaign"]},"updated_at":"2026-07-22T22:26:04Z"}