{"id":{"repo_id":"uiuc","oai_identifier":"oai:www.ideals.illinois.edu:2142/71301"},"canonical_url":"https://search.dev.ndltd.org/etd/uiuc/oai:www.ideals.illinois.edu:2142/71301","repository":{"repo_id":"uiuc","name":"University of Illinois - Urbana-Champaign","base_url":"https://www.ideals.illinois.edu/oai-pmh"},"display":{"title":"Absorption, Distribution and Excretion of Oxytetracycline and Tetracycline in Female Beagles","abstract":"The absorption, distribution and excretion of oxytetracycline and tetracycline were studied in female beagles following intra-arterial and oral drug administration. Concentrations of drug in body fluids and selected tissues were determined by high performance liquid chromatography utilizing an internal standard. The average biologic half-life of oxytetracycline was 6.4 hours, whereas that of tetracycline was 13.7 hours following intra-arterial administration (10 mg/kg body weight). The half-life of tetracycline was decreased to 8.2 hours when a lower dose (5 mg/kg body weight) was administered. Oxytetracycline and tetracycline were rapidly but incompletely absorbed when administered to canines per os. Both antibiotics had similar absorption (< 0.5 hr) and elimination (4.8-6.6 hrs) half-lives. Comparisons of the recovery of both drugs in urine following intra-arterial and oral drug administration revealed that tetracycline had a higher bioavailability (35.9%) than that determined for oxytetracycline (10.7%). Following intra-arterial administration of oxytetracycline (10 mg/kg body weight) the highest concentration of drug was present in the kidney, followed by the liver, heart, muscle, and lung in declining order of concentration. A positive correlation was demonstrated between coexistent mean plasma and tissue concentrations for the tissues examined.","abstract_html":"The absorption, distribution and excretion of oxytetracycline and tetracycline were studied in female beagles following intra-arterial and oral drug administration. Concentrations of drug in body fluids and selected tissues were determined by high performance liquid chromatography utilizing an internal standard. The average biologic half-life of oxytetracycline was 6.4 hours, whereas that of tetracycline was 13.7 hours following intra-arterial administration (10 mg/kg body weight). The half-life of tetracycline was decreased to 8.2 hours when a lower dose (5 mg/kg body weight) was administered. Oxytetracycline and tetracycline were rapidly but incompletely absorbed when administered to canines per os. Both antibiotics had similar absorption (< 0.5 hr) and elimination (4.8-6.6 hrs) half-lives. Comparisons of the recovery of both drugs in urine following intra-arterial and oral drug administration revealed that tetracycline had a higher bioavailability (35.9%) than that determined for oxytetracycline (10.7%). Following intra-arterial administration of oxytetracycline (10 mg/kg body weight) the highest concentration of drug was present in the kidney, followed by the liver, heart, muscle, and lung in declining order of concentration. A positive correlation was demonstrated between coexistent mean plasma and tissue concentrations for the tissues examined.","abstract_has_math":false,"creators":["Bass, Vivian Dee"],"institution":"University of Illinois at Urbana-Champaign","degree_name":"Ph.D.","degree_level":"Dissertation","degree_discipline":"Veterinary Medical Science","degree_department":null,"school":null,"contributors":[],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2014,"date_issued":"2014-12-16T06:35:26Z","date_published":"2014-12-16T06:35:26Z","updated_at":"2026-07-22T22:26:04Z","subjects":["Health Sciences, Pharmacology"],"languages":[],"rights":[],"rights_urls":[],"identifier_entries":[{"key":"dc:identifier","label":"Identifier","values":["(UMI)AAI8309909"],"render_values":[{"text":"(UMI)AAI8309909","href":null,"code":true}]}]},"links":{"outbound_url":"http://hdl.handle.net/2142/71301","outbound_label":"Handle","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:creator","label":"Author","values":["Bass, Vivian Dee"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["2014-12-16T06:35:26Z","10000-01-01","1983"]},{"key":"dc:type","label":"Dc Type","values":["text"]},{"key":"thesis:degree_discipline","label":"Discipline","values":["Veterinary Medical Science"]},{"key":"thesis:degree_level","label":"Degree Level","values":["Dissertation"]},{"key":"thesis:degree_name","label":"Degree Name","values":["Ph.D."]},{"key":"thesis:institution_name","label":"Thesis Institution Name","values":["University of Illinois at Urbana-Champaign"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Health Sciences, Pharmacology"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["http://hdl.handle.net/2142/71301","(UMI)AAI8309909"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["The absorption, distribution and excretion of oxytetracycline and tetracycline were studied in female beagles following intra-arterial and oral drug administration. Concentrations of drug in body fluids and selected tissues were determined by high performance liquid chromatography utilizing an internal standard. The average biologic half-life of oxytetracycline was 6.4 hours, whereas that of tetracycline was 13.7 hours following intra-arterial administration (10 mg/kg body weight). The half-life of tetracycline was decreased to 8.2 hours when a lower dose (5 mg/kg body weight) was administered. Oxytetracycline and tetracycline were rapidly but incompletely absorbed when administered to canines per os. Both antibiotics had similar absorption (< 0.5 hr) and elimination (4.8-6.6 hrs) half-lives. Comparisons of the recovery of both drugs in urine following intra-arterial and oral drug administration revealed that tetracycline had a higher bioavailability (35.9%) than that determined for oxytetracycline (10.7%). Following intra-arterial administration of oxytetracycline (10 mg/kg body weight) the highest concentration of drug was present in the kidney, followed by the liver, heart, muscle, and lung in declining order of concentration. A positive correlation was demonstrated between coexistent mean plasma and tissue concentrations for the tissues examined.","Made available in DSpace on 2014-12-16T06:35:26Z (GMT). No. of bitstreams: 1 8309909.pdf: 5236636 bytes, checksum: baefec997d4ce991347b1f0ba30075d5 (MD5) Previous issue date: 1983","Embargo set by: Seth Robbins for item 71467 Lift date: Forever Reason: Restricted to the U of I community idenfinitely during batch ingest of legacy ETDs","Restricted to the U of I community idenfinitely during batch ingest of legacy ETDs","U of I Only","153 p.","Thesis (Ph.D.)--University of Illinois at Urbana-Champaign, 1983."]},{"key":"dc:title","label":"Title","values":["Absorption, Distribution and Excretion of Oxytetracycline and Tetracycline in Female Beagles"]}]}],"canonical_facts":{"dc:creator":["Bass, Vivian Dee"],"dc:date":["2014-12-16T06:35:26Z","10000-01-01","1983"],"dc:description":["The absorption, distribution and excretion of oxytetracycline and tetracycline were studied in female beagles following intra-arterial and oral drug administration. Concentrations of drug in body fluids and selected tissues were determined by high performance liquid chromatography utilizing an internal standard. The average biologic half-life of oxytetracycline was 6.4 hours, whereas that of tetracycline was 13.7 hours following intra-arterial administration (10 mg/kg body weight). The half-life of tetracycline was decreased to 8.2 hours when a lower dose (5 mg/kg body weight) was administered. Oxytetracycline and tetracycline were rapidly but incompletely absorbed when administered to canines per os. Both antibiotics had similar absorption (< 0.5 hr) and elimination (4.8-6.6 hrs) half-lives. Comparisons of the recovery of both drugs in urine following intra-arterial and oral drug administration revealed that tetracycline had a higher bioavailability (35.9%) than that determined for oxytetracycline (10.7%). Following intra-arterial administration of oxytetracycline (10 mg/kg body weight) the highest concentration of drug was present in the kidney, followed by the liver, heart, muscle, and lung in declining order of concentration. A positive correlation was demonstrated between coexistent mean plasma and tissue concentrations for the tissues examined.","Made available in DSpace on 2014-12-16T06:35:26Z (GMT). No. of bitstreams: 1 8309909.pdf: 5236636 bytes, checksum: baefec997d4ce991347b1f0ba30075d5 (MD5) Previous issue date: 1983","Embargo set by: Seth Robbins for item 71467 Lift date: Forever Reason: Restricted to the U of I community idenfinitely during batch ingest of legacy ETDs","Restricted to the U of I community idenfinitely during batch ingest of legacy ETDs","U of I Only","153 p.","Thesis (Ph.D.)--University of Illinois at Urbana-Champaign, 1983."],"dc:identifier":["http://hdl.handle.net/2142/71301","(UMI)AAI8309909"],"dc:subject":["Health Sciences, Pharmacology"],"dc:title":["Absorption, Distribution and Excretion of Oxytetracycline and Tetracycline in Female Beagles"],"dc:type":["text"],"thesis:degree_discipline":["Veterinary Medical Science"],"thesis:degree_level":["Dissertation"],"thesis:degree_name":["Ph.D."],"thesis:institution_name":["University of Illinois at Urbana-Champaign"]},"updated_at":"2026-07-22T22:26:04Z"}