{"id":{"repo_id":"uiuc","oai_identifier":"oai:www.ideals.illinois.edu:2142/70334"},"canonical_url":"https://search.dev.ndltd.org/etd/uiuc/oai:www.ideals.illinois.edu:2142/70334","repository":{"repo_id":"uiuc","name":"University of Illinois - Urbana-Champaign","base_url":"https://www.ideals.illinois.edu/oai-pmh"},"display":{"title":"Chromatographic Separation of Enantiomers of Some Physiologically Active Types of Compounds on Chiral Stationary Phases (Benzodiazepinones, Beta-Lactams, Beta-Aminoacids)","abstract":"The enantiomers of some important types of compounds have been separated by chromatography on chiral stationary phases. Thus benzodiazepinone enantiomers and enantiomers of aryl substituted (beta)-lactams can be separated directly on amino acid derived chiral stationary phases, whereas (beta)-amino acid enantiomers can be separated, after conversion to the dinitrobenzamide esters, on amide or N-aryl amino acid derived chiral stationary phases. Soluble analogs of the chiral stationary phases were found to induce nonequivalence in the NMR spectra of the two enantiomers of a variety of chiral compounds. The above methods allow the easy evaluation of enantiomeric purities and since chromatographic separability factors are often quite high preparative resolution can be effected even using inexpensive chromatographic techniques such as flash chromatography.","abstract_html":"The enantiomers of some important types of compounds have been separated by chromatography on chiral stationary phases. Thus benzodiazepinone enantiomers and enantiomers of aryl substituted (beta)-lactams can be separated directly on amino acid derived chiral stationary phases, whereas (beta)-amino acid enantiomers can be separated, after conversion to the dinitrobenzamide esters, on amide or N-aryl amino acid derived chiral stationary phases. Soluble analogs of the chiral stationary phases were found to induce nonequivalence in the NMR spectra of the two enantiomers of a variety of chiral compounds. The above methods allow the easy evaluation of enantiomeric purities and since chromatographic separability factors are often quite high preparative resolution can be effected even using inexpensive chromatographic techniques such as flash chromatography.","abstract_has_math":false,"creators":["Tsipouras, Athanasios"],"institution":"University of Illinois at Urbana-Champaign","degree_name":"Ph.D.","degree_level":"Dissertation","degree_discipline":"Chemistry","degree_department":null,"school":null,"contributors":[],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2014,"date_issued":"2014-12-15T23:18:44Z","date_published":"2014-12-15T23:18:44Z","updated_at":"2026-07-22T22:26:02Z","subjects":["Chemistry, Organic"],"languages":[],"rights":[],"rights_urls":[],"identifier_entries":[{"key":"dc:identifier","label":"Identifier","values":["(UMI)AAI8623427"],"render_values":[{"text":"(UMI)AAI8623427","href":null,"code":true}]}]},"links":{"outbound_url":"http://hdl.handle.net/2142/70334","outbound_label":"Handle","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:creator","label":"Author","values":["Tsipouras, Athanasios"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["2014-12-15T23:18:44Z","10000-01-01","1986"]},{"key":"dc:type","label":"Dc Type","values":["text"]},{"key":"thesis:degree_discipline","label":"Discipline","values":["Chemistry"]},{"key":"thesis:degree_level","label":"Degree Level","values":["Dissertation"]},{"key":"thesis:degree_name","label":"Degree Name","values":["Ph.D."]},{"key":"thesis:institution_name","label":"Thesis Institution Name","values":["University of Illinois at Urbana-Champaign"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Chemistry, Organic"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["http://hdl.handle.net/2142/70334","(UMI)AAI8623427"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["The enantiomers of some important types of compounds have been separated by chromatography on chiral stationary phases. Thus benzodiazepinone enantiomers and enantiomers of aryl substituted (beta)-lactams can be separated directly on amino acid derived chiral stationary phases, whereas (beta)-amino acid enantiomers can be separated, after conversion to the dinitrobenzamide esters, on amide or N-aryl amino acid derived chiral stationary phases. Soluble analogs of the chiral stationary phases were found to induce nonequivalence in the NMR spectra of the two enantiomers of a variety of chiral compounds. The above methods allow the easy evaluation of enantiomeric purities and since chromatographic separability factors are often quite high preparative resolution can be effected even using inexpensive chromatographic techniques such as flash chromatography.","Made available in DSpace on 2014-12-15T23:18:44Z (GMT). No. of bitstreams: 1 8623427.pdf: 3966407 bytes, checksum: 3e491d103531d81a93406bbae32b23ba (MD5) Previous issue date: 1986","Embargo set by: Seth Robbins for item 70500 Lift date: Forever Reason: Restricted to the U of I community idenfinitely during batch ingest of legacy ETDs","Restricted to the U of I community idenfinitely during batch ingest of legacy ETDs","U of I Only","138 p.","Thesis (Ph.D.)--University of Illinois at Urbana-Champaign, 1986."]},{"key":"dc:title","label":"Title","values":["Chromatographic Separation of Enantiomers of Some Physiologically Active Types of Compounds on Chiral Stationary Phases (Benzodiazepinones, Beta-Lactams, Beta-Aminoacids)"]}]}],"canonical_facts":{"dc:creator":["Tsipouras, Athanasios"],"dc:date":["2014-12-15T23:18:44Z","10000-01-01","1986"],"dc:description":["The enantiomers of some important types of compounds have been separated by chromatography on chiral stationary phases. Thus benzodiazepinone enantiomers and enantiomers of aryl substituted (beta)-lactams can be separated directly on amino acid derived chiral stationary phases, whereas (beta)-amino acid enantiomers can be separated, after conversion to the dinitrobenzamide esters, on amide or N-aryl amino acid derived chiral stationary phases. Soluble analogs of the chiral stationary phases were found to induce nonequivalence in the NMR spectra of the two enantiomers of a variety of chiral compounds. The above methods allow the easy evaluation of enantiomeric purities and since chromatographic separability factors are often quite high preparative resolution can be effected even using inexpensive chromatographic techniques such as flash chromatography.","Made available in DSpace on 2014-12-15T23:18:44Z (GMT). No. of bitstreams: 1 8623427.pdf: 3966407 bytes, checksum: 3e491d103531d81a93406bbae32b23ba (MD5) Previous issue date: 1986","Embargo set by: Seth Robbins for item 70500 Lift date: Forever Reason: Restricted to the U of I community idenfinitely during batch ingest of legacy ETDs","Restricted to the U of I community idenfinitely during batch ingest of legacy ETDs","U of I Only","138 p.","Thesis (Ph.D.)--University of Illinois at Urbana-Champaign, 1986."],"dc:identifier":["http://hdl.handle.net/2142/70334","(UMI)AAI8623427"],"dc:subject":["Chemistry, Organic"],"dc:title":["Chromatographic Separation of Enantiomers of Some Physiologically Active Types of Compounds on Chiral Stationary Phases (Benzodiazepinones, Beta-Lactams, Beta-Aminoacids)"],"dc:type":["text"],"thesis:degree_discipline":["Chemistry"],"thesis:degree_level":["Dissertation"],"thesis:degree_name":["Ph.D."],"thesis:institution_name":["University of Illinois at Urbana-Champaign"]},"updated_at":"2026-07-22T22:26:02Z"}