Factors Affecting the Toxicity and Metabolism of Organic Arsenicals (Roxarsone, Copper, Cysteine)
type: CreativeWork
description: Experiments were conducted to examine factors affecting the metabolism and toxicity of the organic arsenical, roxarsone (3-nitro-4-hydroxyphenyl-arsonic acid). In experiments with chicks, cysteine enhanced the toxicity of the organic arsenicals, roxarsone and phenylarsonic acid. However, it had little effect on the toxicity of the inorganic arsenicals As(,2)O(,3) and As(,2)O(,5) or the trivalent form of phenylarsonic acid, i.e., phenylarsine oxide. Supplementation of the diet with cystine, methionine or K(,2)SO(,4) did not exacerbate roxarsone toxicity. Reduced glutathione and ascorbic acid, however, each exacerbated roxarsone toxicity. Therefore the potentiation of toxicity requires pentavalent organic arsenicals and compounds which can act as reducing agents. It was concluded that cysteine exacerbates roxarsone toxicity by reducing it to the more toxic trivalent state.
abstract: Experiments were conducted to examine factors affecting the metabolism and toxicity of the organic arsenical, roxarsone (3-nitro-4-hydroxyphenyl-arsonic acid). In experiments with chicks, cysteine enhanced the toxicity of the organic arsenicals, roxarsone and phenylarsonic acid. However, it had little effect on the toxicity of the inorganic arsenicals As(,2)O(,3) and As(,2)O(,5) or the trivalent form of phenylarsonic acid, i.e., phenylarsine oxide. Supplementation of the diet with cystine, methionine or K(,2)SO(,4) did not exacerbate roxarsone toxicity. Reduced glutathione and ascorbic acid, however, each exacerbated roxarsone toxicity. Therefore the potentiation of toxicity requires pentavalent organic arsenicals and compounds which can act as reducing agents. It was concluded that cysteine exacerbates roxarsone toxicity by reducing it to the more toxic trivalent state.
author: Czarnecki, Gail Louise
keywords: Agriculture, Animal Culture and Nutrition
date published: 2014-12-15T21:00:56Z
date modified: 2026-07-22T22:26:02Z
provider: University of Illinois - Urbana-Champaign
publisher: Networked Digital Library of Theses and Dissertations
type: WebPage
source organization: University of Illinois at Urbana-Champaign

PropertyValue
property ID: Handle
value: http://hdl.handle.net/2142/70020