{"id":{"repo_id":"uiuc","oai_identifier":"oai:www.ideals.illinois.edu:2142/70018"},"canonical_url":"https://search.dev.ndltd.org/etd/uiuc/oai:www.ideals.illinois.edu:2142/70018","repository":{"repo_id":"uiuc","name":"University of Illinois - Urbana-Champaign","base_url":"https://www.ideals.illinois.edu/oai-pmh"},"display":{"title":"Biological Activity of Phenolics in Chicks and Rats","abstract":"Plant phenolic monomers and polymers were examined for their effects on various metabolic events in rats and poultry. Chicks fed 6% indulin (a Kraft wood lignin), 12% wood molasses (Masonex('(REGTM))) or 6 and 12% cane molasses all had increased cytochrome P-450 levels over control-fed birds. Chicks fed 6% indulin, with or without nebacitin (bacitracin:neomycin sulfate, 2:1) had higher cytochrome P-450 levels than did chicks fed 0% fiber diets, with or without nebacitin. Rats fed 6% indulin exhibited no difference in MFO activity vs. controls. Chicks fed 6 or 12% indulin had similar amounts of hepatic lipid compared with control-fed birds as did chicks fed 0.5% ferulic acid or 0.5% para-coumaric acid. Hepatic lipid, cytochrome b(,5), cytochrome P-450, serum estradiol, egg weight and egg specific gravity were similar for laying hens fed 6% indulin, 6% arenaceous flour or 0% fiber control diets. Rats fed 6 or 12% indulin had similar hepatic lipid levels compared with controls. Rats fed 0.5% vanillin, 0.5% vanillic acid, 0.5% ferulic acid or 0.5% para-coumaric acid had hepatic lipid levels similar to controls. However, 1% vanillin and 1% vanillic acid depressed lipid accumulation in rats compared to controls. Chicks fed 0.5% vanillin, 0.5% vanillic acid, 0.5% ferulic acid or 0.5% para-coumaric acid had comparable hepatic mixed-function oxidation enzyme levels compared with chicks fed no phenolics. Chicks fed 0.5% para-coumaric acid had lower rates of gain than did chicks fed control or other phenolic-containing diets. Rats fed these phenolics had similar cytochrome P-450 levels. Vanillin had no antioxidant activity when compared to alpha-tocopherol in tocopherol-stripped corn oil in vitro. Results of the previously described experiments suggest that complex plant phenolics do indeed play a role in animal metabolism via the cytochrome P-450 system. The exact phenolic(s) responsible for this induction was not elucidated. Rats do not appear to be affected by these complex phenolics which may be the result of differing isozymes or inherent differences in tolerance to plant xenobiotics compared to chicks.","abstract_html":"Plant phenolic monomers and polymers were examined for their effects on various metabolic events in rats and poultry. Chicks fed 6% indulin (a Kraft wood lignin), 12% wood molasses (Masonex('(REGTM))) or 6 and 12% cane molasses all had increased cytochrome P-450 levels over control-fed birds. Chicks fed 6% indulin, with or without nebacitin (bacitracin:neomycin sulfate, 2:1) had higher cytochrome P-450 levels than did chicks fed 0% fiber diets, with or without nebacitin. Rats fed 6% indulin exhibited no difference in MFO activity vs. controls. Chicks fed 6 or 12% indulin had similar amounts of hepatic lipid compared with control-fed birds as did chicks fed 0.5% ferulic acid or 0.5% para-coumaric acid. Hepatic lipid, cytochrome b(,5), cytochrome P-450, serum estradiol, egg weight and egg specific gravity were similar for laying hens fed 6% indulin, 6% arenaceous flour or 0% fiber control diets. Rats fed 6 or 12% indulin had similar hepatic lipid levels compared with controls. Rats fed 0.5% vanillin, 0.5% vanillic acid, 0.5% ferulic acid or 0.5% para-coumaric acid had hepatic lipid levels similar to controls. However, 1% vanillin and 1% vanillic acid depressed lipid accumulation in rats compared to controls. Chicks fed 0.5% vanillin, 0.5% vanillic acid, 0.5% ferulic acid or 0.5% para-coumaric acid had comparable hepatic mixed-function oxidation enzyme levels compared with chicks fed no phenolics. Chicks fed 0.5% para-coumaric acid had lower rates of gain than did chicks fed control or other phenolic-containing diets. Rats fed these phenolics had similar cytochrome P-450 levels. Vanillin had no antioxidant activity when compared to alpha-tocopherol in tocopherol-stripped corn oil in vitro. Results of the previously described experiments suggest that complex plant phenolics do indeed play a role in animal metabolism via the cytochrome P-450 system. The exact phenolic(s) responsible for this induction was not elucidated. Rats do not appear to be affected by these complex phenolics which may be the result of differing isozymes or inherent differences in tolerance to plant xenobiotics compared to chicks.","abstract_has_math":false,"creators":["Allen, Susan E."],"institution":"University of Illinois at Urbana-Champaign","degree_name":"Ph.D.","degree_level":"Dissertation","degree_discipline":"Animal Sciences","degree_department":null,"school":null,"contributors":[],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2014,"date_issued":"2014-12-15T21:00:56Z","date_published":"2014-12-15T21:00:56Z","updated_at":"2026-07-22T22:26:02Z","subjects":["Biology, Veterinary Science"],"languages":[],"rights":[],"rights_urls":[],"identifier_entries":[{"key":"dc:identifier","label":"Identifier","values":["(UMI)AAI8502056"],"render_values":[{"text":"(UMI)AAI8502056","href":null,"code":true}]}]},"links":{"outbound_url":"http://hdl.handle.net/2142/70018","outbound_label":"Handle","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:creator","label":"Author","values":["Allen, Susan E."]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["2014-12-15T21:00:56Z","10000-01-01","1984"]},{"key":"dc:type","label":"Dc Type","values":["text"]},{"key":"thesis:degree_discipline","label":"Discipline","values":["Animal Sciences"]},{"key":"thesis:degree_level","label":"Degree Level","values":["Dissertation"]},{"key":"thesis:degree_name","label":"Degree Name","values":["Ph.D."]},{"key":"thesis:institution_name","label":"Thesis Institution Name","values":["University of Illinois at Urbana-Champaign"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Biology, Veterinary Science"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["http://hdl.handle.net/2142/70018","(UMI)AAI8502056"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["Plant phenolic monomers and polymers were examined for their effects on various metabolic events in rats and poultry. Chicks fed 6% indulin (a Kraft wood lignin), 12% wood molasses (Masonex('(REGTM))) or 6 and 12% cane molasses all had increased cytochrome P-450 levels over control-fed birds. Chicks fed 6% indulin, with or without nebacitin (bacitracin:neomycin sulfate, 2:1) had higher cytochrome P-450 levels than did chicks fed 0% fiber diets, with or without nebacitin. Rats fed 6% indulin exhibited no difference in MFO activity vs. controls. Chicks fed 6 or 12% indulin had similar amounts of hepatic lipid compared with control-fed birds as did chicks fed 0.5% ferulic acid or 0.5% para-coumaric acid. Hepatic lipid, cytochrome b(,5), cytochrome P-450, serum estradiol, egg weight and egg specific gravity were similar for laying hens fed 6% indulin, 6% arenaceous flour or 0% fiber control diets. Rats fed 6 or 12% indulin had similar hepatic lipid levels compared with controls. Rats fed 0.5% vanillin, 0.5% vanillic acid, 0.5% ferulic acid or 0.5% para-coumaric acid had hepatic lipid levels similar to controls. However, 1% vanillin and 1% vanillic acid depressed lipid accumulation in rats compared to controls. Chicks fed 0.5% vanillin, 0.5% vanillic acid, 0.5% ferulic acid or 0.5% para-coumaric acid had comparable hepatic mixed-function oxidation enzyme levels compared with chicks fed no phenolics. Chicks fed 0.5% para-coumaric acid had lower rates of gain than did chicks fed control or other phenolic-containing diets. Rats fed these phenolics had similar cytochrome P-450 levels. Vanillin had no antioxidant activity when compared to alpha-tocopherol in tocopherol-stripped corn oil in vitro. Results of the previously described experiments suggest that complex plant phenolics do indeed play a role in animal metabolism via the cytochrome P-450 system. The exact phenolic(s) responsible for this induction was not elucidated. Rats do not appear to be affected by these complex phenolics which may be the result of differing isozymes or inherent differences in tolerance to plant xenobiotics compared to chicks.","Made available in DSpace on 2014-12-15T21:00:56Z (GMT). No. of bitstreams: 1 8502056.pdf: 3782078 bytes, checksum: b3b6c324669b9388fbf83ec39796b55f (MD5) Previous issue date: 1984","Embargo set by: Seth Robbins for item 70184 Lift date: Forever Reason: Restricted to the U of I community idenfinitely during batch ingest of legacy ETDs","Restricted to the U of I community idenfinitely during batch ingest of legacy ETDs","U of I Only","108 p.","Thesis (Ph.D.)--University of Illinois at Urbana-Champaign, 1984."]},{"key":"dc:title","label":"Title","values":["Biological Activity of Phenolics in Chicks and Rats"]}]}],"canonical_facts":{"dc:creator":["Allen, Susan E."],"dc:date":["2014-12-15T21:00:56Z","10000-01-01","1984"],"dc:description":["Plant phenolic monomers and polymers were examined for their effects on various metabolic events in rats and poultry. Chicks fed 6% indulin (a Kraft wood lignin), 12% wood molasses (Masonex('(REGTM))) or 6 and 12% cane molasses all had increased cytochrome P-450 levels over control-fed birds. Chicks fed 6% indulin, with or without nebacitin (bacitracin:neomycin sulfate, 2:1) had higher cytochrome P-450 levels than did chicks fed 0% fiber diets, with or without nebacitin. Rats fed 6% indulin exhibited no difference in MFO activity vs. controls. Chicks fed 6 or 12% indulin had similar amounts of hepatic lipid compared with control-fed birds as did chicks fed 0.5% ferulic acid or 0.5% para-coumaric acid. Hepatic lipid, cytochrome b(,5), cytochrome P-450, serum estradiol, egg weight and egg specific gravity were similar for laying hens fed 6% indulin, 6% arenaceous flour or 0% fiber control diets. Rats fed 6 or 12% indulin had similar hepatic lipid levels compared with controls. Rats fed 0.5% vanillin, 0.5% vanillic acid, 0.5% ferulic acid or 0.5% para-coumaric acid had hepatic lipid levels similar to controls. However, 1% vanillin and 1% vanillic acid depressed lipid accumulation in rats compared to controls. Chicks fed 0.5% vanillin, 0.5% vanillic acid, 0.5% ferulic acid or 0.5% para-coumaric acid had comparable hepatic mixed-function oxidation enzyme levels compared with chicks fed no phenolics. Chicks fed 0.5% para-coumaric acid had lower rates of gain than did chicks fed control or other phenolic-containing diets. Rats fed these phenolics had similar cytochrome P-450 levels. Vanillin had no antioxidant activity when compared to alpha-tocopherol in tocopherol-stripped corn oil in vitro. Results of the previously described experiments suggest that complex plant phenolics do indeed play a role in animal metabolism via the cytochrome P-450 system. The exact phenolic(s) responsible for this induction was not elucidated. Rats do not appear to be affected by these complex phenolics which may be the result of differing isozymes or inherent differences in tolerance to plant xenobiotics compared to chicks.","Made available in DSpace on 2014-12-15T21:00:56Z (GMT). No. of bitstreams: 1 8502056.pdf: 3782078 bytes, checksum: b3b6c324669b9388fbf83ec39796b55f (MD5) Previous issue date: 1984","Embargo set by: Seth Robbins for item 70184 Lift date: Forever Reason: Restricted to the U of I community idenfinitely during batch ingest of legacy ETDs","Restricted to the U of I community idenfinitely during batch ingest of legacy ETDs","U of I Only","108 p.","Thesis (Ph.D.)--University of Illinois at Urbana-Champaign, 1984."],"dc:identifier":["http://hdl.handle.net/2142/70018","(UMI)AAI8502056"],"dc:subject":["Biology, Veterinary Science"],"dc:title":["Biological Activity of Phenolics in Chicks and Rats"],"dc:type":["text"],"thesis:degree_discipline":["Animal Sciences"],"thesis:degree_level":["Dissertation"],"thesis:degree_name":["Ph.D."],"thesis:institution_name":["University of Illinois at Urbana-Champaign"]},"updated_at":"2026-07-22T22:26:02Z"}