{"id":{"repo_id":"uiuc","oai_identifier":"oai:www.ideals.illinois.edu:2142/69401"},"canonical_url":"https://search.dev.ndltd.org/etd/uiuc/oai:www.ideals.illinois.edu:2142/69401","repository":{"repo_id":"uiuc","name":"University of Illinois - Urbana-Champaign","base_url":"https://www.ideals.illinois.edu/oai-pmh"},"display":{"title":"Two-Dimensional Electrode Array Studies of Propagating Epileptiform Neural Activity in the Rat Hippocampal Slice","abstract":"A technique has been developed in which a planar array of 32 microelectrodes, arranged in a 4 by 8 pattern with 200 $\\mu$m separation, is used to record from and to stimulate the rat hippocampal slice preparation at multiple sites. Active suppression circuitry is used to prevent device saturation due to large stimulation artifacts. Control of media flow past the tissue is critical to observe signals and to preserve viability. The field potentials recorded are spatially unique and provide a two-dimensional description of the underlying population activity in the various pyramidal cell strata and subpopulations. The application of current source density analysis to the potential data permits accurate determination of peak times, in addition to the estimation of local current sources and sinks. Propagation delays of the compound action potential, first, and second population spikes along CAl calculated using these peak times are not uniform, and may indicate differences and directionality in coupling mechanisms.","abstract_html":"A technique has been developed in which a planar array of 32 microelectrodes, arranged in a 4 by 8 pattern with 200 <span class=\"etd-inline-math\">&mu;</span>m separation, is used to record from and to stimulate the rat hippocampal slice preparation at multiple sites. Active suppression circuitry is used to prevent device saturation due to large stimulation artifacts. Control of media flow past the tissue is critical to observe signals and to preserve viability. The field potentials recorded are spatially unique and provide a two-dimensional description of the underlying population activity in the various pyramidal cell strata and subpopulations. The application of current source density analysis to the potential data permits accurate determination of peak times, in addition to the estimation of local current sources and sinks. Propagation delays of the compound action potential, first, and second population spikes along CAl calculated using these peak times are not uniform, and may indicate differences and directionality in coupling mechanisms.","abstract_has_math":true,"creators":["Novak, James Lawrence"],"institution":"University of Illinois at Urbana-Champaign","degree_name":"Ph.D.","degree_level":"Dissertation","degree_discipline":"Electrical Engineering","degree_department":null,"school":null,"contributors":[],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2014,"date_issued":"2014-12-15T19:05:35Z","date_published":"2014-12-15T19:05:35Z","updated_at":"2026-07-22T22:26:00Z","subjects":["Biology, Neuroscience","Engineering, Biomedical","Engineering, Electronics and Electrical"],"languages":[],"rights":[],"rights_urls":[],"identifier_entries":[{"key":"dc:identifier","label":"Identifier","values":["(UMI)AAI8823217"],"render_values":[{"text":"(UMI)AAI8823217","href":null,"code":true}]}]},"links":{"outbound_url":"http://hdl.handle.net/2142/69401","outbound_label":"Handle","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:creator","label":"Author","values":["Novak, James Lawrence"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["2014-12-15T19:05:35Z","10000-01-01","1988"]},{"key":"dc:type","label":"Dc Type","values":["text"]},{"key":"thesis:degree_discipline","label":"Discipline","values":["Electrical Engineering"]},{"key":"thesis:degree_level","label":"Degree Level","values":["Dissertation"]},{"key":"thesis:degree_name","label":"Degree Name","values":["Ph.D."]},{"key":"thesis:institution_name","label":"Thesis Institution Name","values":["University of Illinois at Urbana-Champaign"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Biology, Neuroscience","Engineering, Biomedical","Engineering, Electronics and Electrical"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["http://hdl.handle.net/2142/69401","(UMI)AAI8823217"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["A technique has been developed in which a planar array of 32 microelectrodes, arranged in a 4 by 8 pattern with 200 $\\mu$m separation, is used to record from and to stimulate the rat hippocampal slice preparation at multiple sites. Active suppression circuitry is used to prevent device saturation due to large stimulation artifacts. Control of media flow past the tissue is critical to observe signals and to preserve viability. The field potentials recorded are spatially unique and provide a two-dimensional description of the underlying population activity in the various pyramidal cell strata and subpopulations. The application of current source density analysis to the potential data permits accurate determination of peak times, in addition to the estimation of local current sources and sinks. Propagation delays of the compound action potential, first, and second population spikes along CAl calculated using these peak times are not uniform, and may indicate differences and directionality in coupling mechanisms.","Made available in DSpace on 2014-12-15T19:05:35Z (GMT). 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Active suppression circuitry is used to prevent device saturation due to large stimulation artifacts. Control of media flow past the tissue is critical to observe signals and to preserve viability. The field potentials recorded are spatially unique and provide a two-dimensional description of the underlying population activity in the various pyramidal cell strata and subpopulations. The application of current source density analysis to the potential data permits accurate determination of peak times, in addition to the estimation of local current sources and sinks. Propagation delays of the compound action potential, first, and second population spikes along CAl calculated using these peak times are not uniform, and may indicate differences and directionality in coupling mechanisms.","Made available in DSpace on 2014-12-15T19:05:35Z (GMT). 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