{"id":{"repo_id":"uiuc","oai_identifier":"oai:www.ideals.illinois.edu:2142/69267"},"canonical_url":"https://search.dev.ndltd.org/etd/uiuc/oai:www.ideals.illinois.edu:2142/69267","repository":{"repo_id":"uiuc","name":"University of Illinois - Urbana-Champaign","base_url":"https://www.ideals.illinois.edu/oai-pmh"},"display":{"title":"Measurement of the Nonlinearity Parameter B/a in Biological Materials Using the Finite Amplitude and Thermodynamic Method","abstract":"It is well-known that materials exhibit a decrease in compressibility when subjected to high compression. This decrease in compressibility may be described by the nonlinearity parameter B/A. Organic liquids have been shown to possess a wide variation of the parameter, ranging from 5 to 12. This thesis reports on the measurement of this parameter in biological materials, including tissue models and soft tissue. An acoustic method with the potential for in vivo measurements is developed for this purpose. The result of measurements is confirmed by a second method which determines the change of sound speed, and hence the compressibility, with changes in hydrostatic pressure and temperature. The measurements indicate that: (1) B/A increases approximately linearly with solute concentration for protein solutions; (2) B/A is relatively insensitive to the molecular weight of the solute for a fixed concentration; (3) B/A ranges from 6.5 to 11 for various soft tissues; and (4) B/A decreases when the cellular structure of a tissue is destroyed. It is felt that details of nonlinear ultrasonic propagation in living systems should contribute to the development of clinical diagnostic and therapeutic applications of ultrasound.","abstract_html":"It is well-known that materials exhibit a decrease in compressibility when subjected to high compression. This decrease in compressibility may be described by the nonlinearity parameter B/A. Organic liquids have been shown to possess a wide variation of the parameter, ranging from 5 to 12. This thesis reports on the measurement of this parameter in biological materials, including tissue models and soft tissue. An acoustic method with the potential for in vivo measurements is developed for this purpose. The result of measurements is confirmed by a second method which determines the change of sound speed, and hence the compressibility, with changes in hydrostatic pressure and temperature. The measurements indicate that: (1) B/A increases approximately linearly with solute concentration for protein solutions; (2) B/A is relatively insensitive to the molecular weight of the solute for a fixed concentration; (3) B/A ranges from 6.5 to 11 for various soft tissues; and (4) B/A decreases when the cellular structure of a tissue is destroyed. It is felt that details of nonlinear ultrasonic propagation in living systems should contribute to the development of clinical diagnostic and therapeutic applications of ultrasound.","abstract_has_math":false,"creators":["Law, Wing Kong"],"institution":"University of Illinois at Urbana-Champaign","degree_name":"Ph.D.","degree_level":"Dissertation","degree_discipline":"Electrical Engineering","degree_department":null,"school":null,"contributors":[],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2014,"date_issued":"2014-12-15T19:04:37Z","date_published":"2014-12-15T19:04:37Z","updated_at":"2026-07-22T22:26:00Z","subjects":["Physics, Acoustics"],"languages":[],"rights":[],"rights_urls":[],"identifier_entries":[{"key":"dc:identifier","label":"Identifier","values":["(UMI)AAI8409800"],"render_values":[{"text":"(UMI)AAI8409800","href":null,"code":true}]}]},"links":{"outbound_url":"http://hdl.handle.net/2142/69267","outbound_label":"Handle","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:creator","label":"Author","values":["Law, Wing Kong"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["2014-12-15T19:04:37Z","10000-01-01","1984"]},{"key":"dc:type","label":"Dc Type","values":["text"]},{"key":"thesis:degree_discipline","label":"Discipline","values":["Electrical Engineering"]},{"key":"thesis:degree_level","label":"Degree Level","values":["Dissertation"]},{"key":"thesis:degree_name","label":"Degree Name","values":["Ph.D."]},{"key":"thesis:institution_name","label":"Thesis Institution Name","values":["University of Illinois at Urbana-Champaign"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Physics, Acoustics"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["http://hdl.handle.net/2142/69267","(UMI)AAI8409800"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["It is well-known that materials exhibit a decrease in compressibility when subjected to high compression. This decrease in compressibility may be described by the nonlinearity parameter B/A. Organic liquids have been shown to possess a wide variation of the parameter, ranging from 5 to 12. This thesis reports on the measurement of this parameter in biological materials, including tissue models and soft tissue. An acoustic method with the potential for in vivo measurements is developed for this purpose. The result of measurements is confirmed by a second method which determines the change of sound speed, and hence the compressibility, with changes in hydrostatic pressure and temperature. The measurements indicate that: (1) B/A increases approximately linearly with solute concentration for protein solutions; (2) B/A is relatively insensitive to the molecular weight of the solute for a fixed concentration; (3) B/A ranges from 6.5 to 11 for various soft tissues; and (4) B/A decreases when the cellular structure of a tissue is destroyed. It is felt that details of nonlinear ultrasonic propagation in living systems should contribute to the development of clinical diagnostic and therapeutic applications of ultrasound.","Made available in DSpace on 2014-12-15T19:04:37Z (GMT). No. of bitstreams: 1 8409800.pdf: 4102877 bytes, checksum: 3d1c1520812d9e0a72c3e773db3a4f38 (MD5) Previous issue date: 1984","Embargo set by: Seth Robbins for item 69433 Lift date: Forever Reason: Restricted to the U of I community idenfinitely during batch ingest of legacy ETDs","Restricted to the U of I community idenfinitely during batch ingest of legacy ETDs","U of I Only","135 p.","Thesis (Ph.D.)--University of Illinois at Urbana-Champaign, 1984."]},{"key":"dc:title","label":"Title","values":["Measurement of the Nonlinearity Parameter B/a in Biological Materials Using the Finite Amplitude and Thermodynamic Method"]}]}],"canonical_facts":{"dc:creator":["Law, Wing Kong"],"dc:date":["2014-12-15T19:04:37Z","10000-01-01","1984"],"dc:description":["It is well-known that materials exhibit a decrease in compressibility when subjected to high compression. This decrease in compressibility may be described by the nonlinearity parameter B/A. Organic liquids have been shown to possess a wide variation of the parameter, ranging from 5 to 12. This thesis reports on the measurement of this parameter in biological materials, including tissue models and soft tissue. An acoustic method with the potential for in vivo measurements is developed for this purpose. The result of measurements is confirmed by a second method which determines the change of sound speed, and hence the compressibility, with changes in hydrostatic pressure and temperature. The measurements indicate that: (1) B/A increases approximately linearly with solute concentration for protein solutions; (2) B/A is relatively insensitive to the molecular weight of the solute for a fixed concentration; (3) B/A ranges from 6.5 to 11 for various soft tissues; and (4) B/A decreases when the cellular structure of a tissue is destroyed. It is felt that details of nonlinear ultrasonic propagation in living systems should contribute to the development of clinical diagnostic and therapeutic applications of ultrasound.","Made available in DSpace on 2014-12-15T19:04:37Z (GMT). No. of bitstreams: 1 8409800.pdf: 4102877 bytes, checksum: 3d1c1520812d9e0a72c3e773db3a4f38 (MD5) Previous issue date: 1984","Embargo set by: Seth Robbins for item 69433 Lift date: Forever Reason: Restricted to the U of I community idenfinitely during batch ingest of legacy ETDs","Restricted to the U of I community idenfinitely during batch ingest of legacy ETDs","U of I Only","135 p.","Thesis (Ph.D.)--University of Illinois at Urbana-Champaign, 1984."],"dc:identifier":["http://hdl.handle.net/2142/69267","(UMI)AAI8409800"],"dc:subject":["Physics, Acoustics"],"dc:title":["Measurement of the Nonlinearity Parameter B/a in Biological Materials Using the Finite Amplitude and Thermodynamic Method"],"dc:type":["text"],"thesis:degree_discipline":["Electrical Engineering"],"thesis:degree_level":["Dissertation"],"thesis:degree_name":["Ph.D."],"thesis:institution_name":["University of Illinois at Urbana-Champaign"]},"updated_at":"2026-07-22T22:26:00Z"}