Studies of Reaction Mechanisms Requiring Low Molecular Weight Thiol Cofactors
The methyl-transfer reaction between methylcobalamin and 2-mercapto-ethanesulfonic acid (Coenzyme M) was investigated. We propose that this reaction is a thiyl radical promoted homolytic cleavage of the cobalt-carbon bond rather than the nucleophilic attack by thiolate anion which has been pro
University of Illinois - Urbana-Champaign
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University of Illinois at Urbana-Champaign