{"id":{"repo_id":"uiuc","oai_identifier":"oai:www.ideals.illinois.edu:2142/49842"},"canonical_url":"https://search.dev.ndltd.org/etd/uiuc/oai:www.ideals.illinois.edu:2142/49842","repository":{"repo_id":"uiuc","name":"University of Illinois - Urbana-Champaign","base_url":"https://www.ideals.illinois.edu/oai-pmh"},"display":{"title":"Enhancing learning and memory in the aged: Interactions between dietary supplementation and exercise","abstract":"Item marked as restricted to the 'Administrator' Group (id=1) by Seth Robbins (robbins.sd@gmail.com) on 2014-05-30T17:21:44Z Item is restricted until 2016-05-30T17:21:23Z","abstract_html":"Item marked as restricted to the 'Administrator' Group (id=1) by Seth Robbins (robbins.sd@gmail.com) on 2014-05-30T17:21:44Z Item is restricted until 2016-05-30T17:21:23Z","abstract_has_math":false,"creators":["Gibbons, Trisha"],"institution":"University of Illinois at Urbana-Champaign","degree_name":"M.S.","degree_level":"Thesis","degree_discipline":"Nutritional Sciences","degree_department":null,"school":null,"contributors":["Johnson, Rodney W."],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2014,"date_issued":"2014-05-30T17:20:35Z","date_published":"2014-05-30T17:20:35Z","updated_at":"2026-07-22T22:25:40Z","subjects":["Aging","exercise","nutrition","epigallocatechin gallate","β-alanine","learning and memory","cognition","oxidative stress","hippocampus"],"languages":["en"],"rights":["Copyright 2014 Trisha Gibbons"],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"http://hdl.handle.net/2142/49842","outbound_label":"Handle","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["Johnson, Rodney W."]},{"key":"dc:creator","label":"Author","values":["Gibbons, Trisha"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["2014-05-30T17:20:35Z","2016-09-22T20:59:18Z","2014-05"]},{"key":"dc:type","label":"Dc Type","values":["text"]},{"key":"thesis:degree_discipline","label":"Discipline","values":["Nutritional Sciences"]},{"key":"thesis:degree_level","label":"Degree Level","values":["Thesis"]},{"key":"thesis:degree_name","label":"Degree Name","values":["M.S."]},{"key":"thesis:institution_name","label":"Thesis Institution Name","values":["University of Illinois at Urbana-Champaign"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Aging","exercise","nutrition","epigallocatechin gallate","β-alanine","learning and memory","cognition","oxidative stress","hippocampus"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["en"]},{"key":"dc:rights","label":"Dc Rights","values":["Copyright 2014 Trisha Gibbons"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["http://hdl.handle.net/2142/49842"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["Item marked as restricted to the 'Administrator' Group (id=1) by Seth Robbins (robbins.sd@gmail.com) on 2014-05-30T17:21:44Z Item is restricted until 2016-05-30T17:21:23Z","Restriction data tranferred 2014-07-01T11:39:49-05:00 Original Data Group with Access Administrator Release Date: 2016-05-30 12:21:23 UTC Reason: Author requested closed access (OA after 2yrs) in Vireo ETD system","Limited Restriction Lifted for Item 49893 on 2016-09-22T20:59:18Z.","Age associated cognitive decline in human and rodents has been linked with decreases in hippocampal neurogenesis and a chronic low grade inflammation in the central nervous system. Physical exercise increases neurogenesis and reverses some cognitive deficits observed in the elderly, but the extent to which dietary supplementation may interact with exercise is unknown. Epigallocatechin gallate (EGCG, a catechin high in green tea) can ameliorate age-related cognitive decline. In addition, β-alanine (β-Ala, a naturally occurring amino acid) may be beneficial against cognitive aging. We hypothesized that exercise (voluntary wheel running, VWR) and dietary supplementation with EGCG (182 mg/kg/d) and β-Ala (417 mg/kg/d) would interact to improve cognition of aged mice. Balb/c mice aged (19 mo) served as sedentary controls or were provided access to running with or without EGCG + β-Ala for 4 weeks. The Morris water maze (MWM) and contextual fear conditioning (CFC) were used to assess learning and memory while BrdU labeling was used to measure new cell proliferation in the dentate gyrus (DG). VWR improved cognition during probe trials in the MWM, increased time spent frozen during both context and auditory cue testing in CFC, and increased BDNF mRNA expression within hippocampus. Dietary supplementation did not affect any of these measurements. Collectively, these data verify that exercise has positive effects on cognition of aged mice by enhancing newborn cells in the DG and increasing neurotrophin expression.","Item withdrawn by Laura Spradlin (lspradl2@illinois.edu) on 2014-05-01T21:41:04Z Item was in collections: University of Illinois Theses & Dissertations (ID: 1) No. of bitstreams: 1 Gibbons_Trisha.pdf: 1105104 bytes, checksum: 3aa7d7ef795a6801f94db25340a8774f (MD5)","Made available in DSpace on 2014-05-30T17:20:35Z (GMT). No. of bitstreams: 2 Trisha_Gibbons.pdf: 1105131 bytes, checksum: a00066947f98cfc2b3b749538b285d13 (MD5) license.txt: 4064 bytes, checksum: eecb09b4dc2bb70b5e7f29056e7a7911 (MD5)"]},{"key":"dc:title","label":"Title","values":["Enhancing learning and memory in the aged: Interactions between dietary supplementation and exercise"]}]}],"canonical_facts":{"dc:contributor":["Johnson, Rodney W."],"dc:creator":["Gibbons, Trisha"],"dc:date":["2014-05-30T17:20:35Z","2016-09-22T20:59:18Z","2014-05"],"dc:description":["Item marked as restricted to the 'Administrator' Group (id=1) by Seth Robbins (robbins.sd@gmail.com) on 2014-05-30T17:21:44Z Item is restricted until 2016-05-30T17:21:23Z","Restriction data tranferred 2014-07-01T11:39:49-05:00 Original Data Group with Access Administrator Release Date: 2016-05-30 12:21:23 UTC Reason: Author requested closed access (OA after 2yrs) in Vireo ETD system","Limited Restriction Lifted for Item 49893 on 2016-09-22T20:59:18Z.","Age associated cognitive decline in human and rodents has been linked with decreases in hippocampal neurogenesis and a chronic low grade inflammation in the central nervous system. Physical exercise increases neurogenesis and reverses some cognitive deficits observed in the elderly, but the extent to which dietary supplementation may interact with exercise is unknown. Epigallocatechin gallate (EGCG, a catechin high in green tea) can ameliorate age-related cognitive decline. In addition, β-alanine (β-Ala, a naturally occurring amino acid) may be beneficial against cognitive aging. We hypothesized that exercise (voluntary wheel running, VWR) and dietary supplementation with EGCG (182 mg/kg/d) and β-Ala (417 mg/kg/d) would interact to improve cognition of aged mice. Balb/c mice aged (19 mo) served as sedentary controls or were provided access to running with or without EGCG + β-Ala for 4 weeks. The Morris water maze (MWM) and contextual fear conditioning (CFC) were used to assess learning and memory while BrdU labeling was used to measure new cell proliferation in the dentate gyrus (DG). VWR improved cognition during probe trials in the MWM, increased time spent frozen during both context and auditory cue testing in CFC, and increased BDNF mRNA expression within hippocampus. Dietary supplementation did not affect any of these measurements. Collectively, these data verify that exercise has positive effects on cognition of aged mice by enhancing newborn cells in the DG and increasing neurotrophin expression.","Item withdrawn by Laura Spradlin (lspradl2@illinois.edu) on 2014-05-01T21:41:04Z Item was in collections: University of Illinois Theses & Dissertations (ID: 1) No. of bitstreams: 1 Gibbons_Trisha.pdf: 1105104 bytes, checksum: 3aa7d7ef795a6801f94db25340a8774f (MD5)","Made available in DSpace on 2014-05-30T17:20:35Z (GMT). No. of bitstreams: 2 Trisha_Gibbons.pdf: 1105131 bytes, checksum: a00066947f98cfc2b3b749538b285d13 (MD5) license.txt: 4064 bytes, checksum: eecb09b4dc2bb70b5e7f29056e7a7911 (MD5)"],"dc:identifier":["http://hdl.handle.net/2142/49842"],"dc:language":["en"],"dc:rights":["Copyright 2014 Trisha Gibbons"],"dc:subject":["Aging","exercise","nutrition","epigallocatechin gallate","β-alanine","learning and memory","cognition","oxidative stress","hippocampus"],"dc:title":["Enhancing learning and memory in the aged: Interactions between dietary supplementation and exercise"],"dc:type":["text"],"thesis:degree_discipline":["Nutritional Sciences"],"thesis:degree_level":["Thesis"],"thesis:degree_name":["M.S."],"thesis:institution_name":["University of Illinois at Urbana-Champaign"]},"updated_at":"2026-07-22T22:25:40Z"}