{"id":{"repo_id":"uiuc","oai_identifier":"oai:www.ideals.illinois.edu:2142/46914"},"canonical_url":"https://search.dev.ndltd.org/etd/uiuc/oai:www.ideals.illinois.edu:2142/46914","repository":{"repo_id":"uiuc","name":"University of Illinois - Urbana-Champaign","base_url":"https://www.ideals.illinois.edu/oai-pmh"},"display":{"title":"Worm-shaped polymersomes and their effects on targeting efficiency","abstract":"In order to improve the targeting efficiency of polymersomes with a given number of targeting molecules conjugated, efforts are being made to control particle shape. I hypothesized that worm-shaped polymersomes formed from self-assembly between poly(amino acid)s would have more targeting capability than spherical polymersomes. Morphology of the resulting polymersome was observed afterwards. The polymersome was further modified to present Arg-Gly-Asp (RGD) motif, which is known to bind with cells that overexpress integrins. The binding affinities of the polymersomes onto target substrates were assessed using surface plasmon resonance (SPR) spectroscopy and adherence of the polymersomes to a target cell layer was also evaluated using flow chamber simulating blood flow.","abstract_html":"In order to improve the targeting efficiency of polymersomes with a given number of targeting molecules conjugated, efforts are being made to control particle shape. I hypothesized that worm-shaped polymersomes formed from self-assembly between poly(amino acid)s would have more targeting capability than spherical polymersomes. Morphology of the resulting polymersome was observed afterwards. The polymersome was further modified to present Arg-Gly-Asp (RGD) motif, which is known to bind with cells that overexpress integrins. The binding affinities of the polymersomes onto target substrates were assessed using surface plasmon resonance (SPR) spectroscopy and adherence of the polymersomes to a target cell layer was also evaluated using flow chamber simulating blood flow.","abstract_has_math":false,"creators":["Choi, Je"],"institution":"University of Illinois at Urbana-Champaign","degree_name":"M.S.","degree_level":"Thesis","degree_discipline":"Chemical Engineering","degree_department":null,"school":null,"contributors":["Kong, Hyun Joon"],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2014,"date_issued":"2014-01-16T18:26:11Z","date_published":"2014-01-16T18:26:11Z","updated_at":"2026-07-22T22:25:38Z","subjects":["particle shape"],"languages":["en"],"rights":["Copyright 2013 Je Choi"],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"http://hdl.handle.net/2142/46914","outbound_label":"Handle","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["Kong, Hyun Joon"]},{"key":"dc:creator","label":"Author","values":["Choi, Je"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["2014-01-16T18:26:11Z","2016-01-16T11:00:55Z","2013-12"]},{"key":"dc:type","label":"Dc Type","values":["text"]},{"key":"thesis:degree_discipline","label":"Discipline","values":["Chemical Engineering"]},{"key":"thesis:degree_level","label":"Degree Level","values":["Thesis"]},{"key":"thesis:degree_name","label":"Degree Name","values":["M.S."]},{"key":"thesis:institution_name","label":"Thesis Institution Name","values":["University of Illinois at Urbana-Champaign"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["particle shape"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["en"]},{"key":"dc:rights","label":"Dc Rights","values":["Copyright 2013 Je Choi"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["http://hdl.handle.net/2142/46914"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["In order to improve the targeting efficiency of polymersomes with a given number of targeting molecules conjugated, efforts are being made to control particle shape. 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I hypothesized that worm-shaped polymersomes formed from self-assembly between poly(amino acid)s would have more targeting capability than spherical polymersomes. Morphology of the resulting polymersome was observed afterwards. The polymersome was further modified to present Arg-Gly-Asp (RGD) motif, which is known to bind with cells that overexpress integrins. The binding affinities of the polymersomes onto target substrates were assessed using surface plasmon resonance (SPR) spectroscopy and adherence of the polymersomes to a target cell layer was also evaluated using flow chamber simulating blood flow.","Item withdrawn by Laura Spradlin (lspradl2@illinois.edu) on 2013-12-10T23:11:05Z Item was in collections: University of Illinois Theses & Dissertations (ID: 1) No. of bitstreams: 1 Choi_Je.pdf: 2242903 bytes, checksum: a8b90da270be48b03763f7c45a24c8f4 (MD5)","Made available in DSpace on 2014-01-16T18:26:11Z (GMT). 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