{"id":{"repo_id":"uiuc","oai_identifier":"oai:www.ideals.illinois.edu:2142/46894"},"canonical_url":"https://search.dev.ndltd.org/etd/uiuc/oai:www.ideals.illinois.edu:2142/46894","repository":{"repo_id":"uiuc","name":"University of Illinois - Urbana-Champaign","base_url":"https://www.ideals.illinois.edu/oai-pmh"},"display":{"title":"Chemical diversification and anticancer activity of natural products","abstract":"Made available in DSpace on 2014-01-16T18:25:34Z (GMT). No. of bitstreams: 3 Karen_Morrison.pdf: 14532423 bytes, checksum: af6a40d935f8782447ddd84ef12a94ae (MD5) Morrison_Karen.docx: 44256739 bytes, checksum: 6353cc66b66320dd9c663bda8c68747b (MD5) license.txt: 4063 bytes, checksum: dc76c097f3fe09e3664b9edcb1c0c2af (MD5)","abstract_html":"Made available in DSpace on 2014-01-16T18:25:34Z (GMT). No. of bitstreams: 3 Karen_Morrison.pdf: 14532423 bytes, checksum: af6a40d935f8782447ddd84ef12a94ae (MD5) Morrison_Karen.docx: 44256739 bytes, checksum: 6353cc66b66320dd9c663bda8c68747b (MD5) license.txt: 4063 bytes, checksum: dc76c097f3fe09e3664b9edcb1c0c2af (MD5)","abstract_has_math":false,"creators":["Morrison, Karen"],"institution":"University of Illinois at Urbana-Champaign","degree_name":"Ph.D.","degree_level":"Dissertation","degree_discipline":"Chemistry","degree_department":null,"school":null,"contributors":["Hergenrother, Paul J.","Katzenellenbogen, John A.","van der Donk, Wilfred A.","Mitchell, Douglas A."],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2014,"date_issued":"2014-01-16T18:25:34Z","date_published":"2014-01-16T18:25:34Z","updated_at":"2026-07-22T22:25:38Z","subjects":["Organic Synthesis","Complexity to Diversity","Natural Products","Anticancer"],"languages":["en"],"rights":["Copyright 2013 Karen C. Morrison"],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"http://hdl.handle.net/2142/46894","outbound_label":"Handle","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["Hergenrother, Paul J.","Katzenellenbogen, John A.","van der Donk, Wilfred A.","Mitchell, Douglas A."]},{"key":"dc:creator","label":"Author","values":["Morrison, Karen"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["2014-01-16T18:25:34Z","2016-01-16T11:01:24Z","2013-12"]},{"key":"dc:type","label":"Dc Type","values":["text"]},{"key":"thesis:degree_discipline","label":"Discipline","values":["Chemistry"]},{"key":"thesis:degree_level","label":"Degree Level","values":["Dissertation"]},{"key":"thesis:degree_name","label":"Degree Name","values":["Ph.D."]},{"key":"thesis:institution_name","label":"Thesis Institution Name","values":["University of Illinois at Urbana-Champaign"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Organic Synthesis","Complexity to Diversity","Natural Products","Anticancer"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["en"]},{"key":"dc:rights","label":"Dc Rights","values":["Copyright 2013 Karen C. Morrison"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["http://hdl.handle.net/2142/46894"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["Made available in DSpace on 2014-01-16T18:25:34Z (GMT). No. of bitstreams: 3 Karen_Morrison.pdf: 14532423 bytes, checksum: af6a40d935f8782447ddd84ef12a94ae (MD5) Morrison_Karen.docx: 44256739 bytes, checksum: 6353cc66b66320dd9c663bda8c68747b (MD5) license.txt: 4063 bytes, checksum: dc76c097f3fe09e3664b9edcb1c0c2af (MD5)","Restriction data tranferred 2014-07-01T11:36:44-05:00 Original Data Group with Access Administrator Release Date: 2016-01-16 12:27:27 UTC Reason: Author requested closed access (OA after 2yrs) in Vireo ETD system","Natural products have historically formed the backbone of modern drug discovery efforts, particularly for cancer and bacterial infections. Despite this privileged status, difficulties associated with the isolation of new natural products or the de novo synthesis of established natural products, coupled with a growth in high throughput screening, led to a decreased emphasis on natural products for drug discovery during the 1990s. The last decade has brought a renaissance in natural product research in terms of new techniques for isolation, synthesis, and biological characterization and with it a renewed appreciation for the importance of these complex molecules. The chapters herein reflect this interest in natural products as important tools for drug discovery. Chapter 1 highlights the synthetic utility of natural products for the creation of complex small molecules for screening libraries. Chapter 2 details specific work with the natural product gibberellic acid for the synthesis of complex and diverse compounds, and chapter 3 covers the screening of these compounds and the biological characterization of a primary hit, GEM-1. Chapters 4 and 5 focus on the anticancer characterization of two classes of natural products: the epipolythiodiketopiperazines alkaloids and the iridoids prismatomerin and plumericin, respectively. Finally, chapter 6 describes the development of a new analytical method for the cellular analysis of a common target of natural products, the biopolymer tubulin.","Item withdrawn by Mark Zulauf (zulauf@illinois.edu) on 2013-08-27T18:53:28Z Item was in collections: University of Illinois Theses & Dissertations (ID: 1) No. of bitstreams: 2 Morrison_Karen.docx: 44502588 bytes, checksum: f42f2b5f79057250184b2965f3a49cdb (MD5) Morrison_Karen.pdf: 14672679 bytes, checksum: 6fc85ba786883d777fe3b9a7171b6a09 (MD5)","Item marked as restricted to the 'Administrator' Group (id=1) by Seth Robbins (robbins.sd@gmail.com) on 2014-01-16T18:27:32Z Item is restricted until 2016-01-16T18:27:27Z","Limited Restriction Lifted for Item 46913 on 2016-01-16T11:01:24Z."]},{"key":"dc:title","label":"Title","values":["Chemical diversification and anticancer activity of natural products"]}]}],"canonical_facts":{"dc:contributor":["Hergenrother, Paul J.","Katzenellenbogen, John A.","van der Donk, Wilfred A.","Mitchell, Douglas A."],"dc:creator":["Morrison, Karen"],"dc:date":["2014-01-16T18:25:34Z","2016-01-16T11:01:24Z","2013-12"],"dc:description":["Made available in DSpace on 2014-01-16T18:25:34Z (GMT). No. of bitstreams: 3 Karen_Morrison.pdf: 14532423 bytes, checksum: af6a40d935f8782447ddd84ef12a94ae (MD5) Morrison_Karen.docx: 44256739 bytes, checksum: 6353cc66b66320dd9c663bda8c68747b (MD5) license.txt: 4063 bytes, checksum: dc76c097f3fe09e3664b9edcb1c0c2af (MD5)","Restriction data tranferred 2014-07-01T11:36:44-05:00 Original Data Group with Access Administrator Release Date: 2016-01-16 12:27:27 UTC Reason: Author requested closed access (OA after 2yrs) in Vireo ETD system","Natural products have historically formed the backbone of modern drug discovery efforts, particularly for cancer and bacterial infections. Despite this privileged status, difficulties associated with the isolation of new natural products or the de novo synthesis of established natural products, coupled with a growth in high throughput screening, led to a decreased emphasis on natural products for drug discovery during the 1990s. The last decade has brought a renaissance in natural product research in terms of new techniques for isolation, synthesis, and biological characterization and with it a renewed appreciation for the importance of these complex molecules. The chapters herein reflect this interest in natural products as important tools for drug discovery. Chapter 1 highlights the synthetic utility of natural products for the creation of complex small molecules for screening libraries. Chapter 2 details specific work with the natural product gibberellic acid for the synthesis of complex and diverse compounds, and chapter 3 covers the screening of these compounds and the biological characterization of a primary hit, GEM-1. Chapters 4 and 5 focus on the anticancer characterization of two classes of natural products: the epipolythiodiketopiperazines alkaloids and the iridoids prismatomerin and plumericin, respectively. Finally, chapter 6 describes the development of a new analytical method for the cellular analysis of a common target of natural products, the biopolymer tubulin.","Item withdrawn by Mark Zulauf (zulauf@illinois.edu) on 2013-08-27T18:53:28Z Item was in collections: University of Illinois Theses & Dissertations (ID: 1) No. of bitstreams: 2 Morrison_Karen.docx: 44502588 bytes, checksum: f42f2b5f79057250184b2965f3a49cdb (MD5) Morrison_Karen.pdf: 14672679 bytes, checksum: 6fc85ba786883d777fe3b9a7171b6a09 (MD5)","Item marked as restricted to the 'Administrator' Group (id=1) by Seth Robbins (robbins.sd@gmail.com) on 2014-01-16T18:27:32Z Item is restricted until 2016-01-16T18:27:27Z","Limited Restriction Lifted for Item 46913 on 2016-01-16T11:01:24Z."],"dc:identifier":["http://hdl.handle.net/2142/46894"],"dc:language":["en"],"dc:rights":["Copyright 2013 Karen C. Morrison"],"dc:subject":["Organic Synthesis","Complexity to Diversity","Natural Products","Anticancer"],"dc:title":["Chemical diversification and anticancer activity of natural products"],"dc:type":["text"],"thesis:degree_discipline":["Chemistry"],"thesis:degree_level":["Dissertation"],"thesis:degree_name":["Ph.D."],"thesis:institution_name":["University of Illinois at Urbana-Champaign"]},"updated_at":"2026-07-22T22:25:38Z"}