{"id":{"repo_id":"uiuc","oai_identifier":"oai:www.ideals.illinois.edu:2142/46779"},"canonical_url":"https://search.dev.ndltd.org/etd/uiuc/oai:www.ideals.illinois.edu:2142/46779","repository":{"repo_id":"uiuc","name":"University of Illinois - Urbana-Champaign","base_url":"https://www.ideals.illinois.edu/oai-pmh"},"display":{"title":"Investigation of aryldimethylsilanolates in palladium-catalyzed cross-coupling reactions and development of chiral bis-hydrazone ligands for asymmetric aryl-aryl couplings","abstract":"The preparation of biaryls by palladium-catalyzed cross-coupling of aromatic bromides and chlorides with alkali-metal salts (potassium and sodium) of aryl- and heteroarylsilanols has been developed. The critical feature for the success of this method is the use of bis(tri-tert-butylphosphine)palladium catalyst. Under the optimized reaction conditions, a range of coupling partners bearing different functionalities have been examined and provide biaryl products in moderate to good yields. Refinement of the mechanism for this reaction is facilitated by the ability to prepare a variety of arylpalladium(II) silanolate intermediates from easily accessible aryldimethylsilanolates. These in situ generated complexes enable kinetic studies of the transmetalation step in the proposed catalytic cycle under stoichiometric conditions. Hammett analysis reveals that electron-donating groups on the silicon nucleophile and electron-withdrawing groups on the aryl halide electrophile accelerate this process. Further interpretation of the kinetic data leads to the proposal of an intramolecular, asynchronous, SEAr-type transmetalation pathway. The application of aryldimethylsilanolate to asymmetric biaryl cross-coupling reactions has been investigated. Pivotal to this study is the development of a novel synthetic route to access a number of chiral bis-hydrazone ligands featuring a 2,5-diarylpyrrolidine moiety. This endeavor enables systematic investigation of the ligand effect on the reactivity and enantioselectivity of the reaction. The origin of the chiral induction has been rationalized through computational modeling. Preliminary mechanistic studies indicate that reductive elimination is the stereodeteremining step. Efforts in the preparation of palladium complexes of an achiral bis-hydrazone ligand have laid the groundwork for future development.","abstract_html":"The preparation of biaryls by palladium-catalyzed cross-coupling of aromatic bromides and chlorides with alkali-metal salts (potassium and sodium) of aryl- and heteroarylsilanols has been developed. The critical feature for the success of this method is the use of bis(tri-tert-butylphosphine)palladium catalyst. Under the optimized reaction conditions, a range of coupling partners bearing different functionalities have been examined and provide biaryl products in moderate to good yields. Refinement of the mechanism for this reaction is facilitated by the ability to prepare a variety of arylpalladium(II) silanolate intermediates from easily accessible aryldimethylsilanolates. These in situ generated complexes enable kinetic studies of the transmetalation step in the proposed catalytic cycle under stoichiometric conditions. Hammett analysis reveals that electron-donating groups on the silicon nucleophile and electron-withdrawing groups on the aryl halide electrophile accelerate this process. Further interpretation of the kinetic data leads to the proposal of an intramolecular, asynchronous, SEAr-type transmetalation pathway. The application of aryldimethylsilanolate to asymmetric biaryl cross-coupling reactions has been investigated. Pivotal to this study is the development of a novel synthetic route to access a number of chiral bis-hydrazone ligands featuring a 2,5-diarylpyrrolidine moiety. This endeavor enables systematic investigation of the ligand effect on the reactivity and enantioselectivity of the reaction. The origin of the chiral induction has been rationalized through computational modeling. Preliminary mechanistic studies indicate that reductive elimination is the stereodeteremining step. Efforts in the preparation of palladium complexes of an achiral bis-hydrazone ligand have laid the groundwork for future development.","abstract_has_math":false,"creators":["Chang, Wen-Tau"],"institution":"University of Illinois at Urbana-Champaign","degree_name":"Ph.D.","degree_level":"Dissertation","degree_discipline":"Chemistry","degree_department":null,"school":null,"contributors":["Denmark, Scott E.","Burke, Martin D.","Hull, Kami L.","Murphy, Catherine J."],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2014,"date_issued":"2014-01-16T18:02:16Z","date_published":"2014-01-16T18:02:16Z","updated_at":"2026-07-22T22:25:36Z","subjects":["Cross Coupling","Hiyama Coupling","Biaryl","Silanolate","Transmetalation","Hammett Study","Hydrazone Ligand","Asymmetric Aryl-Aryl Coupling"],"languages":["en"],"rights":["Copyright 2013 Wen-Tau Chang"],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"http://hdl.handle.net/2142/46779","outbound_label":"Handle","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["Denmark, Scott E.","Burke, Martin D.","Hull, Kami L.","Murphy, Catherine J."]},{"key":"dc:creator","label":"Author","values":["Chang, Wen-Tau"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["2014-01-16T18:02:16Z","2013-12"]},{"key":"dc:type","label":"Dc Type","values":["text"]},{"key":"thesis:degree_discipline","label":"Discipline","values":["Chemistry"]},{"key":"thesis:degree_level","label":"Degree Level","values":["Dissertation"]},{"key":"thesis:degree_name","label":"Degree Name","values":["Ph.D."]},{"key":"thesis:institution_name","label":"Thesis Institution Name","values":["University of Illinois at Urbana-Champaign"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Cross Coupling","Hiyama Coupling","Biaryl","Silanolate","Transmetalation","Hammett Study","Hydrazone Ligand","Asymmetric Aryl-Aryl Coupling"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["en"]},{"key":"dc:rights","label":"Dc Rights","values":["Copyright 2013 Wen-Tau Chang"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["http://hdl.handle.net/2142/46779"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["The preparation of biaryls by palladium-catalyzed cross-coupling of aromatic bromides and chlorides with alkali-metal salts (potassium and sodium) of aryl- and heteroarylsilanols has been developed. The critical feature for the success of this method is the use of bis(tri-tert-butylphosphine)palladium catalyst. Under the optimized reaction conditions, a range of coupling partners bearing different functionalities have been examined and provide biaryl products in moderate to good yields. Refinement of the mechanism for this reaction is facilitated by the ability to prepare a variety of arylpalladium(II) silanolate intermediates from easily accessible aryldimethylsilanolates. These in situ generated complexes enable kinetic studies of the transmetalation step in the proposed catalytic cycle under stoichiometric conditions. Hammett analysis reveals that electron-donating groups on the silicon nucleophile and electron-withdrawing groups on the aryl halide electrophile accelerate this process. Further interpretation of the kinetic data leads to the proposal of an intramolecular, asynchronous, SEAr-type transmetalation pathway. The application of aryldimethylsilanolate to asymmetric biaryl cross-coupling reactions has been investigated. Pivotal to this study is the development of a novel synthetic route to access a number of chiral bis-hydrazone ligands featuring a 2,5-diarylpyrrolidine moiety. This endeavor enables systematic investigation of the ligand effect on the reactivity and enantioselectivity of the reaction. The origin of the chiral induction has been rationalized through computational modeling. Preliminary mechanistic studies indicate that reductive elimination is the stereodeteremining step. Efforts in the preparation of palladium complexes of an achiral bis-hydrazone ligand have laid the groundwork for future development.","Item withdrawn by Mark Zulauf (zulauf@illinois.edu) on 2013-08-09T15:36:20Z Item was in collections: University of Illinois Theses & Dissertations (ID: 1) No. of bitstreams: 2 Chang_Wen-Tau.docx: 18208791 bytes, checksum: 8a5997275a6e24b03213725ad2014920 (MD5) Chang_Wen-Tau.pdf: 7486353 bytes, checksum: 676d3b439fd08b0ea8cefe3eea734e7a (MD5)","Made available in DSpace on 2014-01-16T18:02:16Z (GMT). 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The critical feature for the success of this method is the use of bis(tri-tert-butylphosphine)palladium catalyst. Under the optimized reaction conditions, a range of coupling partners bearing different functionalities have been examined and provide biaryl products in moderate to good yields. Refinement of the mechanism for this reaction is facilitated by the ability to prepare a variety of arylpalladium(II) silanolate intermediates from easily accessible aryldimethylsilanolates. These in situ generated complexes enable kinetic studies of the transmetalation step in the proposed catalytic cycle under stoichiometric conditions. Hammett analysis reveals that electron-donating groups on the silicon nucleophile and electron-withdrawing groups on the aryl halide electrophile accelerate this process. Further interpretation of the kinetic data leads to the proposal of an intramolecular, asynchronous, SEAr-type transmetalation pathway. The application of aryldimethylsilanolate to asymmetric biaryl cross-coupling reactions has been investigated. Pivotal to this study is the development of a novel synthetic route to access a number of chiral bis-hydrazone ligands featuring a 2,5-diarylpyrrolidine moiety. This endeavor enables systematic investigation of the ligand effect on the reactivity and enantioselectivity of the reaction. The origin of the chiral induction has been rationalized through computational modeling. Preliminary mechanistic studies indicate that reductive elimination is the stereodeteremining step. Efforts in the preparation of palladium complexes of an achiral bis-hydrazone ligand have laid the groundwork for future development.","Item withdrawn by Mark Zulauf (zulauf@illinois.edu) on 2013-08-09T15:36:20Z Item was in collections: University of Illinois Theses & Dissertations (ID: 1) No. of bitstreams: 2 Chang_Wen-Tau.docx: 18208791 bytes, checksum: 8a5997275a6e24b03213725ad2014920 (MD5) Chang_Wen-Tau.pdf: 7486353 bytes, checksum: 676d3b439fd08b0ea8cefe3eea734e7a (MD5)","Made available in DSpace on 2014-01-16T18:02:16Z (GMT). No. of bitstreams: 3 Wen-Tau_Chang.pdf: 7501492 bytes, checksum: 178f87412bc8e770b2bcd7c4c7c09d3d (MD5) Chang_Wen-Tau.docx: 18261511 bytes, checksum: 6878a3ba5290c00ca37d2efc1d17779a (MD5) license.txt: 4063 bytes, checksum: 3b08b4185ce7d8a2dcd5362d223f945f (MD5)"],"dc:identifier":["http://hdl.handle.net/2142/46779"],"dc:language":["en"],"dc:rights":["Copyright 2013 Wen-Tau Chang"],"dc:subject":["Cross Coupling","Hiyama Coupling","Biaryl","Silanolate","Transmetalation","Hammett Study","Hydrazone Ligand","Asymmetric Aryl-Aryl Coupling"],"dc:title":["Investigation of aryldimethylsilanolates in palladium-catalyzed cross-coupling reactions and development of chiral bis-hydrazone ligands for asymmetric aryl-aryl couplings"],"dc:type":["text"],"thesis:degree_discipline":["Chemistry"],"thesis:degree_level":["Dissertation"],"thesis:degree_name":["Ph.D."],"thesis:institution_name":["University of Illinois at Urbana-Champaign"]},"updated_at":"2026-07-22T22:25:36Z"}