{"id":{"repo_id":"uiuc","oai_identifier":"oai:www.ideals.illinois.edu:2142/45557"},"canonical_url":"https://search.dev.ndltd.org/etd/uiuc/oai:www.ideals.illinois.edu:2142/45557","repository":{"repo_id":"uiuc","name":"University of Illinois - Urbana-Champaign","base_url":"https://www.ideals.illinois.edu/oai-pmh"},"display":{"title":"An iterative cross-coupling based approach to the synthesis of peridinin and progress towards peridinin derivatives","abstract":"Lipoperoxidation plays a role in diseases such as atherosclerosis, rheumatoid arthritis, cancer, and may contribute to the general phenomenon of aging. As individuals with deficiencies of antioxidant proteins are particularly susceptible to these diseases, small molecules with the ability to act as antilipoperoxidants have the potential to serve as powerful pharmaceuticals. Peridinin, an atypical carotenoid found in dinoflagellates responsible for the color of red tide, is especially interesting as a potential antilipoperoxidant because it may act through self-preserving mechanisms, unlike other carotenoids. We report the total synthesis of the protected form of a peridinin derivative lacking the butenolide functionality and contributions towards the development of a stereoretentive Suzuki-Miyaura coupling of haloallenes.","abstract_html":"Lipoperoxidation plays a role in diseases such as atherosclerosis, rheumatoid arthritis, cancer, and may contribute to the general phenomenon of aging. As individuals with deficiencies of antioxidant proteins are particularly susceptible to these diseases, small molecules with the ability to act as antilipoperoxidants have the potential to serve as powerful pharmaceuticals. Peridinin, an atypical carotenoid found in dinoflagellates responsible for the color of red tide, is especially interesting as a potential antilipoperoxidant because it may act through self-preserving mechanisms, unlike other carotenoids. We report the total synthesis of the protected form of a peridinin derivative lacking the butenolide functionality and contributions towards the development of a stereoretentive Suzuki-Miyaura coupling of haloallenes.","abstract_has_math":false,"creators":["Davis, Erin"],"institution":"University of Illinois at Urbana-Champaign","degree_name":"M.S.","degree_level":"Thesis","degree_discipline":"Chemistry","degree_department":null,"school":null,"contributors":["Burke, Martin D."],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2013,"date_issued":"2013-08-22T16:47:44Z","date_published":"2013-08-22T16:47:44Z","updated_at":"2026-07-22T22:25:36Z","subjects":["peridinin","lipoperoxidation","carotenoids","iterative cross coupling"],"languages":["en"],"rights":["Copyright 2013 Erin Davis"],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"http://hdl.handle.net/2142/45557","outbound_label":"Handle","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["Burke, Martin D."]},{"key":"dc:creator","label":"Author","values":["Davis, Erin"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["2013-08-22T16:47:44Z","2015-08-22T10:00:54Z","2013-08"]},{"key":"dc:type","label":"Dc Type","values":["text"]},{"key":"thesis:degree_discipline","label":"Discipline","values":["Chemistry"]},{"key":"thesis:degree_level","label":"Degree Level","values":["Thesis"]},{"key":"thesis:degree_name","label":"Degree Name","values":["M.S."]},{"key":"thesis:institution_name","label":"Thesis Institution Name","values":["University of Illinois at Urbana-Champaign"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["peridinin","lipoperoxidation","carotenoids","iterative cross coupling"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["en"]},{"key":"dc:rights","label":"Dc Rights","values":["Copyright 2013 Erin Davis"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["http://hdl.handle.net/2142/45557"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["Lipoperoxidation plays a role in diseases such as atherosclerosis, rheumatoid arthritis, cancer, and may contribute to the general phenomenon of aging. 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