{"id":{"repo_id":"uiuc","oai_identifier":"oai:www.ideals.illinois.edu:2142/44419"},"canonical_url":"https://search.dev.ndltd.org/etd/uiuc/oai:www.ideals.illinois.edu:2142/44419","repository":{"repo_id":"uiuc","name":"University of Illinois - Urbana-Champaign","base_url":"https://www.ideals.illinois.edu/oai-pmh"},"display":{"title":"Synthesis and characterization of nanoparticle suspensions: Towards quantitative surface-enhanced Raman spectroscopic sensing","abstract":"Surface-enhanced Raman spectroscopy (SERS) is an ultrasensitive technique with applications ranging from in vitro and in vivo biological sensing to chemical and explosives detection. In this thesis, we explore the design and characterization of suspensions of nanoparticles prior to their use for SERS-based molecular sensing. A major problem in SERS-based measurements is that the signals are often not interpreted quantitatively. Measurements performed in suspension mimic the nanoprobe-to-nanoprobe optical interactions expected to be found in tissues with embedded nanoprobes while particle-level measurements of synthesized nanoparticles provide the molecular basis for calculations. We find that careful consideration of the localized surface plasmon resonance of SERS nanoprobes with respect to laser excitation wavelength is essential for maximizing detectable SERS signal. Additionally, the reporter molecule load per particle depends on synthesis conditions and the shape of the nanoparticles. Together, well-characterized suspensions can be used to understand the molecular and electromagnetic aspects of recorded SERS data.","abstract_html":"Surface-enhanced Raman spectroscopy (SERS) is an ultrasensitive technique with applications ranging from in vitro and in vivo biological sensing to chemical and explosives detection. In this thesis, we explore the design and characterization of suspensions of nanoparticles prior to their use for SERS-based molecular sensing. A major problem in SERS-based measurements is that the signals are often not interpreted quantitatively. Measurements performed in suspension mimic the nanoprobe-to-nanoprobe optical interactions expected to be found in tissues with embedded nanoprobes while particle-level measurements of synthesized nanoparticles provide the molecular basis for calculations. We find that careful consideration of the localized surface plasmon resonance of SERS nanoprobes with respect to laser excitation wavelength is essential for maximizing detectable SERS signal. Additionally, the reporter molecule load per particle depends on synthesis conditions and the shape of the nanoparticles. Together, well-characterized suspensions can be used to understand the molecular and electromagnetic aspects of recorded SERS data.","abstract_has_math":false,"creators":["Devetter, Brent M."],"institution":"University of Illinois at Urbana-Champaign","degree_name":"M.S.","degree_level":"Thesis","degree_discipline":"Electrical & Computer Engr","degree_department":null,"school":null,"contributors":["Bhargava, Rohit"],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2013,"date_issued":"2013-05-24T22:15:26Z","date_published":"2013-05-24T22:15:26Z","updated_at":"2026-07-22T22:25:34Z","subjects":["surface-enhanced Raman spectroscopy","gold nanoparticles","plasmonics","chemical sensing"],"languages":["en"],"rights":["Copyright 2013 Brent Devetter"],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"http://hdl.handle.net/2142/44419","outbound_label":"Handle","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["Bhargava, Rohit"]},{"key":"dc:creator","label":"Author","values":["Devetter, Brent M."]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["2013-05-24T22:15:26Z","2015-05-24T10:01:12Z","2013-05"]},{"key":"dc:type","label":"Dc Type","values":["text"]},{"key":"thesis:degree_discipline","label":"Discipline","values":["Electrical & Computer Engr"]},{"key":"thesis:degree_level","label":"Degree Level","values":["Thesis"]},{"key":"thesis:degree_name","label":"Degree Name","values":["M.S."]},{"key":"thesis:institution_name","label":"Thesis Institution Name","values":["University of Illinois at Urbana-Champaign"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["surface-enhanced Raman spectroscopy","gold nanoparticles","plasmonics","chemical sensing"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["en"]},{"key":"dc:rights","label":"Dc Rights","values":["Copyright 2013 Brent Devetter"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["http://hdl.handle.net/2142/44419"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["Surface-enhanced Raman spectroscopy (SERS) is an ultrasensitive technique with applications ranging from in vitro and in vivo biological sensing to chemical and explosives detection. 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