{"id":{"repo_id":"uiuc","oai_identifier":"oai:www.ideals.illinois.edu:2142/44205"},"canonical_url":"https://search.dev.ndltd.org/etd/uiuc/oai:www.ideals.illinois.edu:2142/44205","repository":{"repo_id":"uiuc","name":"University of Illinois - Urbana-Champaign","base_url":"https://www.ideals.illinois.edu/oai-pmh"},"display":{"title":"The inactivation of Coxsackievirus B5 with monochloramine for safe global water","abstract":"Water-borne pathogens, which regularly cause morbidity and mortality, continue to pose a significant obstacle in providing safe global water to the more than 780 million people without access to improved water supply. Coxsackievirus, a RNA water-borne pathogen found worldwide, causes a range of human illnesses including diarrheal diseases and myocarditis. Inactivation of water-borne pathogens has been achieved using disinfectants such as hypochlorous acid or free chlorine. However, Coxsackievirus serotype B5 has demonstrated unique resistance to free chlorine disinfection compared to similar viral pathogens of concern, such as Adenovirus. Due to emerging regulations targeting disinfection byproducts of free chlorine, water utilities are switching to monochloramine as a secondary disinfectant to maintain a residual in distribution systems. Additionally, the use of free chlorine in waters contaminated with ammonia from animal and human waste, a commonality in developing regions with inadequate sanitation, can result in the formation of chloramines. The primary objective of this work is to characterize the kinetics of Coxsackievirus B5 inactivation using monochloramine as a function of temperature and pH conditions relevant to water treatment. The efficiency of dichloramine in viral inactivation was also assessed, and the effect of formaldehyde on monochloramine disinfection of Coxsackievirus B5 was tested. The findings of this work indicate that Coxsackievirus B5 inactivation with monochloramine is affected by both temperature and pH, dichloramine is a relatively ineffective disinfectant, and the presence of formaldehyde does not affect inactivation. The results of this work have implications for future disinfection design in water utilities as well as point-of-use systems for developing and rural regions in dire need of safe water.","abstract_html":"Water-borne pathogens, which regularly cause morbidity and mortality, continue to pose a significant obstacle in providing safe global water to the more than 780 million people without access to improved water supply. Coxsackievirus, a RNA water-borne pathogen found worldwide, causes a range of human illnesses including diarrheal diseases and myocarditis. Inactivation of water-borne pathogens has been achieved using disinfectants such as hypochlorous acid or free chlorine. However, Coxsackievirus serotype B5 has demonstrated unique resistance to free chlorine disinfection compared to similar viral pathogens of concern, such as Adenovirus. Due to emerging regulations targeting disinfection byproducts of free chlorine, water utilities are switching to monochloramine as a secondary disinfectant to maintain a residual in distribution systems. Additionally, the use of free chlorine in waters contaminated with ammonia from animal and human waste, a commonality in developing regions with inadequate sanitation, can result in the formation of chloramines. The primary objective of this work is to characterize the kinetics of Coxsackievirus B5 inactivation using monochloramine as a function of temperature and pH conditions relevant to water treatment. The efficiency of dichloramine in viral inactivation was also assessed, and the effect of formaldehyde on monochloramine disinfection of Coxsackievirus B5 was tested. The findings of this work indicate that Coxsackievirus B5 inactivation with monochloramine is affected by both temperature and pH, dichloramine is a relatively ineffective disinfectant, and the presence of formaldehyde does not affect inactivation. The results of this work have implications for future disinfection design in water utilities as well as point-of-use systems for developing and rural regions in dire need of safe water.","abstract_has_math":false,"creators":["Al-Qadi, Dana"],"institution":"University of Illinois at Urbana-Champaign","degree_name":"M.S.","degree_level":"Thesis","degree_discipline":"Environ Engr in Civil Engr","degree_department":null,"school":null,"contributors":["Mariñas, Benito J."],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2013,"date_issued":"2013-05-24T21:54:09Z","date_published":"2013-05-24T21:54:09Z","updated_at":"2026-07-22T22:25:33Z","subjects":["Coxsackievirus","Monochloramine","Inactivation","Water quality"],"languages":["en"],"rights":["Copyright 2013 Dana Al-Qadi"],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"http://hdl.handle.net/2142/44205","outbound_label":"Handle","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["Mariñas, Benito J."]},{"key":"dc:creator","label":"Author","values":["Al-Qadi, Dana"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["2013-05-24T21:54:09Z","2013-05"]},{"key":"dc:type","label":"Dc Type","values":["text"]},{"key":"thesis:degree_discipline","label":"Discipline","values":["Environ Engr in Civil Engr"]},{"key":"thesis:degree_level","label":"Degree Level","values":["Thesis"]},{"key":"thesis:degree_name","label":"Degree Name","values":["M.S."]},{"key":"thesis:institution_name","label":"Thesis Institution Name","values":["University of Illinois at Urbana-Champaign"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Coxsackievirus","Monochloramine","Inactivation","Water quality"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["en"]},{"key":"dc:rights","label":"Dc Rights","values":["Copyright 2013 Dana Al-Qadi"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["http://hdl.handle.net/2142/44205"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["Water-borne pathogens, which regularly cause morbidity and mortality, continue to pose a significant obstacle in providing safe global water to the more than 780 million people without access to improved water supply. 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The primary objective of this work is to characterize the kinetics of Coxsackievirus B5 inactivation using monochloramine as a function of temperature and pH conditions relevant to water treatment. The efficiency of dichloramine in viral inactivation was also assessed, and the effect of formaldehyde on monochloramine disinfection of Coxsackievirus B5 was tested. The findings of this work indicate that Coxsackievirus B5 inactivation with monochloramine is affected by both temperature and pH, dichloramine is a relatively ineffective disinfectant, and the presence of formaldehyde does not affect inactivation. The results of this work have implications for future disinfection design in water utilities as well as point-of-use systems for developing and rural regions in dire need of safe water.","Item withdrawn by Mark Zulauf (zulauf@illinois.edu) on 2013-04-26T19:23:13Z Item was in collections: University of Illinois Theses & Dissertations (ID: 1) No. of bitstreams: 2 alqadi_dana.docx: 4502055 bytes, checksum: 33a5b3e0df92584eb0d69545198a8657 (MD5) alqadi_dana.pdf: 6000307 bytes, checksum: 1f69228efe5e2bbf3c17d2b6dfe73359 (MD5)","Made available in DSpace on 2013-05-24T21:54:09Z (GMT). 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Inactivation of water-borne pathogens has been achieved using disinfectants such as hypochlorous acid or free chlorine. However, Coxsackievirus serotype B5 has demonstrated unique resistance to free chlorine disinfection compared to similar viral pathogens of concern, such as Adenovirus. Due to emerging regulations targeting disinfection byproducts of free chlorine, water utilities are switching to monochloramine as a secondary disinfectant to maintain a residual in distribution systems. Additionally, the use of free chlorine in waters contaminated with ammonia from animal and human waste, a commonality in developing regions with inadequate sanitation, can result in the formation of chloramines. The primary objective of this work is to characterize the kinetics of Coxsackievirus B5 inactivation using monochloramine as a function of temperature and pH conditions relevant to water treatment. The efficiency of dichloramine in viral inactivation was also assessed, and the effect of formaldehyde on monochloramine disinfection of Coxsackievirus B5 was tested. The findings of this work indicate that Coxsackievirus B5 inactivation with monochloramine is affected by both temperature and pH, dichloramine is a relatively ineffective disinfectant, and the presence of formaldehyde does not affect inactivation. The results of this work have implications for future disinfection design in water utilities as well as point-of-use systems for developing and rural regions in dire need of safe water.","Item withdrawn by Mark Zulauf (zulauf@illinois.edu) on 2013-04-26T19:23:13Z Item was in collections: University of Illinois Theses & Dissertations (ID: 1) No. of bitstreams: 2 alqadi_dana.docx: 4502055 bytes, checksum: 33a5b3e0df92584eb0d69545198a8657 (MD5) alqadi_dana.pdf: 6000307 bytes, checksum: 1f69228efe5e2bbf3c17d2b6dfe73359 (MD5)","Made available in DSpace on 2013-05-24T21:54:09Z (GMT). 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