{"id":{"repo_id":"uiuc","oai_identifier":"oai:www.ideals.illinois.edu:2142/42239"},"canonical_url":"https://search.dev.ndltd.org/etd/uiuc/oai:www.ideals.illinois.edu:2142/42239","repository":{"repo_id":"uiuc","name":"University of Illinois - Urbana-Champaign","base_url":"https://www.ideals.illinois.edu/oai-pmh"},"display":{"title":"Functional genomic studies of regeneration in the planarian Schmidtea mediterranea","abstract":"Regenerative capabilities are seen in varying degrees throughout the phylogenetic tree. Are the genes and signaling pathways employed by regeneration found in all metazoans and recruited by mechanisms conserved in regenerative organisms, or have organisms developed ways to recruit them de novo? We brought the power of comparative genomics to bear on a portion of this broad question, and a cohort of genes was found that appeared to only be conserved in organisms capable of somatic tissue replacement as adults. Those genes were characterized in silico, then whole-mount in situ hybridizations were performed for each gene. Functional analysis using double-stranded RNA-mediated RNA interference (RNAi) was implemented to determine effects on regeneration. The hypothesis was that effectors of regeneration are only conserved in animals capable of somatic tissue regeneration as adults. No genes fitting that particular description were found in this study; however, there were complications with the investigation, and this work leaves the question unresolved.","abstract_html":"Regenerative capabilities are seen in varying degrees throughout the phylogenetic tree. Are the genes and signaling pathways employed by regeneration found in all metazoans and recruited by mechanisms conserved in regenerative organisms, or have organisms developed ways to recruit them de novo? We brought the power of comparative genomics to bear on a portion of this broad question, and a cohort of genes was found that appeared to only be conserved in organisms capable of somatic tissue replacement as adults. Those genes were characterized in silico, then whole-mount in situ hybridizations were performed for each gene. Functional analysis using double-stranded RNA-mediated RNA interference (RNAi) was implemented to determine effects on regeneration. The hypothesis was that effectors of regeneration are only conserved in animals capable of somatic tissue regeneration as adults. No genes fitting that particular description were found in this study; however, there were complications with the investigation, and this work leaves the question unresolved.","abstract_has_math":false,"creators":["Stary, Joel"],"institution":"University of Illinois at Urbana-Champaign","degree_name":"Ph.D.","degree_level":"Dissertation","degree_discipline":"Neuroscience","degree_department":null,"school":null,"contributors":["Newmark, Phillip A.","Robertson, Hugh M.","Gillette, Rhanor","Henry, Jonathan"],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2013,"date_issued":"2013-02-03T19:28:54Z","date_published":"2013-02-03T19:28:54Z","updated_at":"2026-07-22T22:25:33Z","subjects":["Regeneration","Planarian","Planarians","Planaria","Schmidtea mediterranea","Functional genomics"],"languages":["en"],"rights":["Copyright 2012 Joel Stary"],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"http://hdl.handle.net/2142/42239","outbound_label":"Handle","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["Newmark, Phillip A.","Robertson, Hugh M.","Gillette, Rhanor","Henry, Jonathan"]},{"key":"dc:creator","label":"Author","values":["Stary, Joel"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["2013-02-03T19:28:54Z","2012-12"]},{"key":"dc:type","label":"Dc Type","values":["text"]},{"key":"thesis:degree_discipline","label":"Discipline","values":["Neuroscience"]},{"key":"thesis:degree_level","label":"Degree Level","values":["Dissertation"]},{"key":"thesis:degree_name","label":"Degree Name","values":["Ph.D."]},{"key":"thesis:institution_name","label":"Thesis Institution Name","values":["University of Illinois at Urbana-Champaign"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Regeneration","Planarian","Planarians","Planaria","Schmidtea mediterranea","Functional genomics"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["en"]},{"key":"dc:rights","label":"Dc Rights","values":["Copyright 2012 Joel Stary"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["http://hdl.handle.net/2142/42239"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["Regenerative capabilities are seen in varying degrees throughout the phylogenetic tree. Are the genes and signaling pathways employed by regeneration found in all metazoans and recruited by mechanisms conserved in regenerative organisms, or have organisms developed ways to recruit them de novo? We brought the power of comparative genomics to bear on a portion of this broad question, and a cohort of genes was found that appeared to only be conserved in organisms capable of somatic tissue replacement as adults. Those genes were characterized in silico, then whole-mount in situ hybridizations were performed for each gene. Functional analysis using double-stranded RNA-mediated RNA interference (RNAi) was implemented to determine effects on regeneration. The hypothesis was that effectors of regeneration are only conserved in animals capable of somatic tissue regeneration as adults. No genes fitting that particular description were found in this study; however, there were complications with the investigation, and this work leaves the question unresolved.","Item withdrawn by Mark Zulauf (zulauf@illinois.edu) on 2012-12-04T15:25:39Z Item was in collections: University of Illinois Theses & Dissertations (ID: 1) No. of bitstreams: 1 stary_joel.pdf: 29395962 bytes, checksum: 70edba33298e7c11bf6d7d9248fba444 (MD5)","Made available in DSpace on 2013-02-03T19:28:54Z (GMT). No. of bitstreams: 2 Joel_Stary.pdf: 29144945 bytes, checksum: 1e569e98e8a4610ecdf90f30b725e185 (MD5) license.txt: 4062 bytes, checksum: 7a38d4c43e5e0e31571ab858f3aa3cc6 (MD5)"]},{"key":"dc:title","label":"Title","values":["Functional genomic studies of regeneration in the planarian Schmidtea mediterranea"]}]}],"canonical_facts":{"dc:contributor":["Newmark, Phillip A.","Robertson, Hugh M.","Gillette, Rhanor","Henry, Jonathan"],"dc:creator":["Stary, Joel"],"dc:date":["2013-02-03T19:28:54Z","2012-12"],"dc:description":["Regenerative capabilities are seen in varying degrees throughout the phylogenetic tree. Are the genes and signaling pathways employed by regeneration found in all metazoans and recruited by mechanisms conserved in regenerative organisms, or have organisms developed ways to recruit them de novo? We brought the power of comparative genomics to bear on a portion of this broad question, and a cohort of genes was found that appeared to only be conserved in organisms capable of somatic tissue replacement as adults. Those genes were characterized in silico, then whole-mount in situ hybridizations were performed for each gene. Functional analysis using double-stranded RNA-mediated RNA interference (RNAi) was implemented to determine effects on regeneration. The hypothesis was that effectors of regeneration are only conserved in animals capable of somatic tissue regeneration as adults. No genes fitting that particular description were found in this study; however, there were complications with the investigation, and this work leaves the question unresolved.","Item withdrawn by Mark Zulauf (zulauf@illinois.edu) on 2012-12-04T15:25:39Z Item was in collections: University of Illinois Theses & Dissertations (ID: 1) No. of bitstreams: 1 stary_joel.pdf: 29395962 bytes, checksum: 70edba33298e7c11bf6d7d9248fba444 (MD5)","Made available in DSpace on 2013-02-03T19:28:54Z (GMT). No. of bitstreams: 2 Joel_Stary.pdf: 29144945 bytes, checksum: 1e569e98e8a4610ecdf90f30b725e185 (MD5) license.txt: 4062 bytes, checksum: 7a38d4c43e5e0e31571ab858f3aa3cc6 (MD5)"],"dc:identifier":["http://hdl.handle.net/2142/42239"],"dc:language":["en"],"dc:rights":["Copyright 2012 Joel Stary"],"dc:subject":["Regeneration","Planarian","Planarians","Planaria","Schmidtea mediterranea","Functional genomics"],"dc:title":["Functional genomic studies of regeneration in the planarian Schmidtea mediterranea"],"dc:type":["text"],"thesis:degree_discipline":["Neuroscience"],"thesis:degree_level":["Dissertation"],"thesis:degree_name":["Ph.D."],"thesis:institution_name":["University of Illinois at Urbana-Champaign"]},"updated_at":"2026-07-22T22:25:33Z"}