{"id":{"repo_id":"uiuc","oai_identifier":"oai:www.ideals.illinois.edu:2142/30944"},"canonical_url":"https://search.dev.ndltd.org/etd/uiuc/oai:www.ideals.illinois.edu:2142/30944","repository":{"repo_id":"uiuc","name":"University of Illinois - Urbana-Champaign","base_url":"https://www.ideals.illinois.edu/oai-pmh"},"display":{"title":"Individual and combined effects of exercise training and dietary fat on myocardial triglycerides in obese mice","abstract":"Visceral adipose tissue has been suggested to have a stronger association with disease than subcutaneous adipose tissue. This is primarily due to its inflammatory nature. Epicardial adipose tissue is a type of visceral fat located on the exterior of the heart. Recent evidence suggests an association between atherosclerosis, epicardial fat, and hepatic triglyceride deposition. PURPOSE -The purpose of this study was to determine the individual and combined effects of endurance exercise training and changes in dietary fat intake on myocardial triglyceride, a marker of epicardial fat, as well as hepatic triglycerides, another visceral fat depot implicated in CVD and diabetes risk, in a mouse model of dietary induced obesity. METHODS – Male c57BL/6 mice (n=73) fed a 45% high-fat diet for 6-weeks to induce obesity were randomly assigned into four groups: exercise high-fat, exercise low-fat, sedentary high-fat, sedentary low-fat. Exercise intervention consisted of treadmill running for 5 days/week, 40 min/day, at an intensity of 65-70% VO2 max for 12 weeks. After the 12 weeks, animals were sacrificed and both hearts and liver were removed. Using a triglyceride assay, myocardial and liver triglycerides levels were determined. RESULTS – Exercise training significantly lowered liver triglycerides in both high fat and low fat fed mice (p < 0.001 for both groups). However, dietary fat intake did not have a significant effect on liver triglycerides within activity groups. Exercise training also lowered myocardial triglycerides in mice fed a high fat diet (p = 0.005), but had no effect on myocardial triglycerides in mice fed a low fat diet. By contrast, mice fed a low fat diet had significantly lower myocardial triglycerides than high fat fed mice, regardless of activity group (p < 0.01 for both groups). CONCLUSION – Exercise training can attenuate epicardial/myocardial and hepatic fat accumulation in obese mice. Low fat diets can decrease myocardial fat accumulation in obese mice.","abstract_html":"Visceral adipose tissue has been suggested to have a stronger association with disease than subcutaneous adipose tissue. This is primarily due to its inflammatory nature. Epicardial adipose tissue is a type of visceral fat located on the exterior of the heart. Recent evidence suggests an association between atherosclerosis, epicardial fat, and hepatic triglyceride deposition. PURPOSE -The purpose of this study was to determine the individual and combined effects of endurance exercise training and changes in dietary fat intake on myocardial triglyceride, a marker of epicardial fat, as well as hepatic triglycerides, another visceral fat depot implicated in CVD and diabetes risk, in a mouse model of dietary induced obesity. METHODS – Male c57BL/6 mice (n=73) fed a 45% high-fat diet for 6-weeks to induce obesity were randomly assigned into four groups: exercise high-fat, exercise low-fat, sedentary high-fat, sedentary low-fat. Exercise intervention consisted of treadmill running for 5 days/week, 40 min/day, at an intensity of 65-70% VO2 max for 12 weeks. After the 12 weeks, animals were sacrificed and both hearts and liver were removed. Using a triglyceride assay, myocardial and liver triglycerides levels were determined. RESULTS – Exercise training significantly lowered liver triglycerides in both high fat and low fat fed mice (p &lt; 0.001 for both groups). However, dietary fat intake did not have a significant effect on liver triglycerides within activity groups. Exercise training also lowered myocardial triglycerides in mice fed a high fat diet (p = 0.005), but had no effect on myocardial triglycerides in mice fed a low fat diet. By contrast, mice fed a low fat diet had significantly lower myocardial triglycerides than high fat fed mice, regardless of activity group (p &lt; 0.01 for both groups). CONCLUSION – Exercise training can attenuate epicardial/myocardial and hepatic fat accumulation in obese mice. Low fat diets can decrease myocardial fat accumulation in obese mice.","abstract_has_math":false,"creators":["Cortez, Filand"],"institution":"University of Illinois at Urbana-Champaign","degree_name":"M.S.","degree_level":"Thesis","degree_discipline":"Kinesiology","degree_department":null,"school":null,"contributors":["Wilund, Kenneth R."],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2012,"date_issued":"2012-05-22T00:17:32Z","date_published":"2012-05-22T00:17:32Z","updated_at":"2026-07-22T22:25:29Z","subjects":["Epicardial Fat","Myocardial Triglycerides","Exercise"],"languages":["en"],"rights":["Copyright 2012 Filand Cortez"],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"http://hdl.handle.net/2142/30944","outbound_label":"Handle","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["Wilund, Kenneth R."]},{"key":"dc:creator","label":"Author","values":["Cortez, Filand"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["2012-05-22T00:17:32Z","2012-05"]},{"key":"dc:type","label":"Dc Type","values":["text"]},{"key":"thesis:degree_discipline","label":"Discipline","values":["Kinesiology"]},{"key":"thesis:degree_level","label":"Degree Level","values":["Thesis"]},{"key":"thesis:degree_name","label":"Degree Name","values":["M.S."]},{"key":"thesis:institution_name","label":"Thesis Institution Name","values":["University of Illinois at Urbana-Champaign"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Epicardial Fat","Myocardial Triglycerides","Exercise"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["en"]},{"key":"dc:rights","label":"Dc Rights","values":["Copyright 2012 Filand Cortez"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["http://hdl.handle.net/2142/30944"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["Visceral adipose tissue has been suggested to have a stronger association with disease than subcutaneous adipose tissue. This is primarily due to its inflammatory nature. Epicardial adipose tissue is a type of visceral fat located on the exterior of the heart. Recent evidence suggests an association between atherosclerosis, epicardial fat, and hepatic triglyceride deposition. PURPOSE -The purpose of this study was to determine the individual and combined effects of endurance exercise training and changes in dietary fat intake on myocardial triglyceride, a marker of epicardial fat, as well as hepatic triglycerides, another visceral fat depot implicated in CVD and diabetes risk, in a mouse model of dietary induced obesity. METHODS – Male c57BL/6 mice (n=73) fed a 45% high-fat diet for 6-weeks to induce obesity were randomly assigned into four groups: exercise high-fat, exercise low-fat, sedentary high-fat, sedentary low-fat. Exercise intervention consisted of treadmill running for 5 days/week, 40 min/day, at an intensity of 65-70% VO2 max for 12 weeks. After the 12 weeks, animals were sacrificed and both hearts and liver were removed. Using a triglyceride assay, myocardial and liver triglycerides levels were determined. RESULTS – Exercise training significantly lowered liver triglycerides in both high fat and low fat fed mice (p < 0.001 for both groups). However, dietary fat intake did not have a significant effect on liver triglycerides within activity groups. Exercise training also lowered myocardial triglycerides in mice fed a high fat diet (p = 0.005), but had no effect on myocardial triglycerides in mice fed a low fat diet. By contrast, mice fed a low fat diet had significantly lower myocardial triglycerides than high fat fed mice, regardless of activity group (p < 0.01 for both groups). CONCLUSION – Exercise training can attenuate epicardial/myocardial and hepatic fat accumulation in obese mice. Low fat diets can decrease myocardial fat accumulation in obese mice.","Item withdrawn by Mark Zulauf (zulauf@illinois.edu) on 2012-04-16T15:04:38Z Item was in collections: University of Illinois Theses & Dissertations (ID: 1) No. of bitstreams: 1 Cortez_Filand.pdf: 760375 bytes, checksum: d5cd8bfd8914856f8b37b581084e6aa9 (MD5)","Made available in DSpace on 2012-05-22T00:17:32Z (GMT). No. of bitstreams: 2 Cortez_Filand.pdf: 759866 bytes, checksum: 06aeae0a020f254fb1a204abf40d44a2 (MD5) license.txt: 4065 bytes, checksum: 1dd02e5b4286c477260e9f517f33a004 (MD5)"]},{"key":"dc:title","label":"Title","values":["Individual and combined effects of exercise training and dietary fat on myocardial triglycerides in obese mice"]}]}],"canonical_facts":{"dc:contributor":["Wilund, Kenneth R."],"dc:creator":["Cortez, Filand"],"dc:date":["2012-05-22T00:17:32Z","2012-05"],"dc:description":["Visceral adipose tissue has been suggested to have a stronger association with disease than subcutaneous adipose tissue. This is primarily due to its inflammatory nature. Epicardial adipose tissue is a type of visceral fat located on the exterior of the heart. Recent evidence suggests an association between atherosclerosis, epicardial fat, and hepatic triglyceride deposition. PURPOSE -The purpose of this study was to determine the individual and combined effects of endurance exercise training and changes in dietary fat intake on myocardial triglyceride, a marker of epicardial fat, as well as hepatic triglycerides, another visceral fat depot implicated in CVD and diabetes risk, in a mouse model of dietary induced obesity. METHODS – Male c57BL/6 mice (n=73) fed a 45% high-fat diet for 6-weeks to induce obesity were randomly assigned into four groups: exercise high-fat, exercise low-fat, sedentary high-fat, sedentary low-fat. Exercise intervention consisted of treadmill running for 5 days/week, 40 min/day, at an intensity of 65-70% VO2 max for 12 weeks. After the 12 weeks, animals were sacrificed and both hearts and liver were removed. Using a triglyceride assay, myocardial and liver triglycerides levels were determined. RESULTS – Exercise training significantly lowered liver triglycerides in both high fat and low fat fed mice (p < 0.001 for both groups). However, dietary fat intake did not have a significant effect on liver triglycerides within activity groups. Exercise training also lowered myocardial triglycerides in mice fed a high fat diet (p = 0.005), but had no effect on myocardial triglycerides in mice fed a low fat diet. By contrast, mice fed a low fat diet had significantly lower myocardial triglycerides than high fat fed mice, regardless of activity group (p < 0.01 for both groups). CONCLUSION – Exercise training can attenuate epicardial/myocardial and hepatic fat accumulation in obese mice. Low fat diets can decrease myocardial fat accumulation in obese mice.","Item withdrawn by Mark Zulauf (zulauf@illinois.edu) on 2012-04-16T15:04:38Z Item was in collections: University of Illinois Theses & Dissertations (ID: 1) No. of bitstreams: 1 Cortez_Filand.pdf: 760375 bytes, checksum: d5cd8bfd8914856f8b37b581084e6aa9 (MD5)","Made available in DSpace on 2012-05-22T00:17:32Z (GMT). No. of bitstreams: 2 Cortez_Filand.pdf: 759866 bytes, checksum: 06aeae0a020f254fb1a204abf40d44a2 (MD5) license.txt: 4065 bytes, checksum: 1dd02e5b4286c477260e9f517f33a004 (MD5)"],"dc:identifier":["http://hdl.handle.net/2142/30944"],"dc:language":["en"],"dc:rights":["Copyright 2012 Filand Cortez"],"dc:subject":["Epicardial Fat","Myocardial Triglycerides","Exercise"],"dc:title":["Individual and combined effects of exercise training and dietary fat on myocardial triglycerides in obese mice"],"dc:type":["text"],"thesis:degree_discipline":["Kinesiology"],"thesis:degree_level":["Thesis"],"thesis:degree_name":["M.S."],"thesis:institution_name":["University of Illinois at Urbana-Champaign"]},"updated_at":"2026-07-22T22:25:29Z"}