{"id":{"repo_id":"uiuc","oai_identifier":"oai:www.ideals.illinois.edu:2142/26382"},"canonical_url":"https://search.dev.ndltd.org/etd/uiuc/oai:www.ideals.illinois.edu:2142/26382","repository":{"repo_id":"uiuc","name":"University of Illinois - Urbana-Champaign","base_url":"https://www.ideals.illinois.edu/oai-pmh"},"display":{"title":"Development and Mechanistic Characterization of Novel Small Molecules as Cancer Therapeutics","abstract":"The discovery and development of novel small molecules as anti-cancer agents plays an integral role in the fight against cancer. Such efforts will lead to the development of the therapies of tomorrow. Potentially useful molecules may be discovered through cell-based toxicity screens, enzyme-based in vitro screens or developed from computational design against proteins of interest. The elucidation of the mechanism of action of small molecules discovered in cell-based screens remains a challenging endeavor. Whole genome transcript profiling and genome-wide shRNA screens are tools that have recently become available to the researcher and their use in aiding mechanism elucidation is reviewed in Chapter 1. Also presented herein is the development and investigation of the mechanism of action of several novel small molecules that exhibit anti-cancer activity. Genome-wide technologies are employed to characterize the mechanism of several of these molecules. Chapter 2 focuses on the mechanism of a rapid inducer of caspase-dependent apoptosis. Chapters 3 and 4 investigate novel triphenylmethyl containing anticancer agents and compare their mechanisms of action to known agents. The development of lactate dehydrogenase-A (LDH-A) inhibitors as a novel anticancer strategy is discussed in Chapter 5. In Chapter 6, the mode of action of anti-cancer quinones is described. And finally, the discovery of triazole-containing small molecules as tubulin-targeting agents is narrated in Chapter 7.","abstract_html":"The discovery and development of novel small molecules as anti-cancer agents plays an integral role in the fight against cancer. Such efforts will lead to the development of the therapies of tomorrow. Potentially useful molecules may be discovered through cell-based toxicity screens, enzyme-based in vitro screens or developed from computational design against proteins of interest. The elucidation of the mechanism of action of small molecules discovered in cell-based screens remains a challenging endeavor. Whole genome transcript profiling and genome-wide shRNA screens are tools that have recently become available to the researcher and their use in aiding mechanism elucidation is reviewed in Chapter 1. Also presented herein is the development and investigation of the mechanism of action of several novel small molecules that exhibit anti-cancer activity. Genome-wide technologies are employed to characterize the mechanism of several of these molecules. Chapter 2 focuses on the mechanism of a rapid inducer of caspase-dependent apoptosis. Chapters 3 and 4 investigate novel triphenylmethyl containing anticancer agents and compare their mechanisms of action to known agents. The development of lactate dehydrogenase-A (LDH-A) inhibitors as a novel anticancer strategy is discussed in Chapter 5. In Chapter 6, the mode of action of anti-cancer quinones is described. And finally, the discovery of triazole-containing small molecules as tubulin-targeting agents is narrated in Chapter 7.","abstract_has_math":false,"creators":["Palchaudhuri, Rahul"],"institution":"University of Illinois at Urbana-Champaign","degree_name":"Ph.D.","degree_level":"Dissertation","degree_discipline":"Chemistry","degree_department":null,"school":null,"contributors":["Hergenrother, Paul J.","Mitchell, Douglas A.","Shapiro, David J.","Baranger, Anne M."],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2011,"date_issued":"2011-08-26T15:33:58Z","date_published":"2011-08-26T15:33:58Z","updated_at":"2026-07-22T22:25:27Z","subjects":["Cancer","Therapeutic","Mechanism of action","Small Molecule"],"languages":["en"],"rights":["Copyright 2011 Rahul Palchaudhuri"],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"http://hdl.handle.net/2142/26382","outbound_label":"Handle","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["Hergenrother, Paul J.","Mitchell, Douglas A.","Shapiro, David J.","Baranger, Anne M."]},{"key":"dc:creator","label":"Author","values":["Palchaudhuri, Rahul"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["2011-08-26T15:33:58Z","2013-08-27T10:00:26Z","2011-08"]},{"key":"thesis:degree_discipline","label":"Discipline","values":["Chemistry"]},{"key":"thesis:degree_level","label":"Degree Level","values":["Dissertation"]},{"key":"thesis:degree_name","label":"Degree Name","values":["Ph.D."]},{"key":"thesis:institution_name","label":"Thesis Institution Name","values":["University of Illinois at Urbana-Champaign"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Cancer","Therapeutic","Mechanism of action","Small Molecule"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["en"]},{"key":"dc:rights","label":"Dc Rights","values":["Copyright 2011 Rahul Palchaudhuri"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["http://hdl.handle.net/2142/26382"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["The discovery and development of novel small molecules as anti-cancer agents plays an integral role in the fight against cancer. 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Chapters 3 and 4 investigate novel triphenylmethyl containing anticancer agents and compare their mechanisms of action to known agents. The development of lactate dehydrogenase-A (LDH-A) inhibitors as a novel anticancer strategy is discussed in Chapter 5. In Chapter 6, the mode of action of anti-cancer quinones is described. And finally, the discovery of triazole-containing small molecules as tubulin-targeting agents is narrated in Chapter 7.","Item withdrawn by Rebecca Bryant (rabryant@illinois.edu) on 2011-07-13T21:48:14Z Item was in collections: University of Illinois Theses & Dissertations (ID: 1) No. of bitstreams: 1 Palchaudhuri_Rahul.pdf: 6731765 bytes, checksum: aa7a2dcb0ffb909ad5bb4c5ed6304f53 (MD5)","Made available in DSpace on 2011-08-26T15:33:58Z (GMT). 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Chapters 3 and 4 investigate novel triphenylmethyl containing anticancer agents and compare their mechanisms of action to known agents. The development of lactate dehydrogenase-A (LDH-A) inhibitors as a novel anticancer strategy is discussed in Chapter 5. In Chapter 6, the mode of action of anti-cancer quinones is described. And finally, the discovery of triazole-containing small molecules as tubulin-targeting agents is narrated in Chapter 7.","Item withdrawn by Rebecca Bryant (rabryant@illinois.edu) on 2011-07-13T21:48:14Z Item was in collections: University of Illinois Theses & Dissertations (ID: 1) No. of bitstreams: 1 Palchaudhuri_Rahul.pdf: 6731765 bytes, checksum: aa7a2dcb0ffb909ad5bb4c5ed6304f53 (MD5)","Made available in DSpace on 2011-08-26T15:33:58Z (GMT). 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