{"id":{"repo_id":"uiuc","oai_identifier":"oai:www.ideals.illinois.edu:2142/26254"},"canonical_url":"https://search.dev.ndltd.org/etd/uiuc/oai:www.ideals.illinois.edu:2142/26254","repository":{"repo_id":"uiuc","name":"University of Illinois - Urbana-Champaign","base_url":"https://www.ideals.illinois.edu/oai-pmh"},"display":{"title":"Molecular quantification in digital health diagnostic cd with surface modifications","abstract":"This thesis aims to document the experimental quantification of molecules on top of a common compact disc (CD) using the ubiquitous and inexpensive technology of a CD drive. To illustrate the concept, glucose is chosen as the target molecule and a colorimetric enzymatic glucose assay is carried out on top of a modified CD. Test strips, similar to the ones used for blood glucose monitoring, are incorporated on top of a CD with audio files burned on it. When a substance containing glucose is dropped onto the strip the resulting change in optical density is proportional to glucose concentration. Using the laser light, optical pickup and the error detection and correction protocol present in all CD drives, this change in optical density and hence the concentration of glucose in the sample are determined quantitatively. The resulting potential “CD glucose meter” can be a cost-effective, mass-deployable, point-of-care tool for rapid blood glucose monitoring and the diagnosis of diabetes. This CD based method for molecular quantification is independent of the type of target molecule and the concept can hence be extended for quantifying other important molecules and carrying out other diagnostic tests in a multiplexed arrangement.","abstract_html":"This thesis aims to document the experimental quantification of molecules on top of a common compact disc (CD) using the ubiquitous and inexpensive technology of a CD drive. To illustrate the concept, glucose is chosen as the target molecule and a colorimetric enzymatic glucose assay is carried out on top of a modified CD. Test strips, similar to the ones used for blood glucose monitoring, are incorporated on top of a CD with audio files burned on it. When a substance containing glucose is dropped onto the strip the resulting change in optical density is proportional to glucose concentration. Using the laser light, optical pickup and the error detection and correction protocol present in all CD drives, this change in optical density and hence the concentration of glucose in the sample are determined quantitatively. The resulting potential “CD glucose meter” can be a cost-effective, mass-deployable, point-of-care tool for rapid blood glucose monitoring and the diagnosis of diabetes. This CD based method for molecular quantification is independent of the type of target molecule and the concept can hence be extended for quantifying other important molecules and carrying out other diagnostic tests in a multiplexed arrangement.","abstract_has_math":false,"creators":["Majeed, Hassaan"],"institution":"University of Illinois at Urbana-Champaign","degree_name":"M.S.","degree_level":"Thesis","degree_discipline":"Electrical & Computer Engr","degree_department":null,"school":null,"contributors":["Liu, Gang Logan"],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2011,"date_issued":"2011-08-25T22:21:02Z","date_published":"2011-08-25T22:21:02Z","updated_at":"2026-07-22T22:25:26Z","subjects":["Molecular quantification","Point-of-care diagnostics","Compact disc based sensing"],"languages":["en"],"rights":["Copyright 2011 Hassaan Majeed"],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"http://hdl.handle.net/2142/26254","outbound_label":"Handle","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["Liu, Gang Logan"]},{"key":"dc:creator","label":"Author","values":["Majeed, Hassaan"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["2011-08-25T22:21:02Z","2011-08"]},{"key":"thesis:degree_discipline","label":"Discipline","values":["Electrical & Computer Engr"]},{"key":"thesis:degree_level","label":"Degree Level","values":["Thesis"]},{"key":"thesis:degree_name","label":"Degree Name","values":["M.S."]},{"key":"thesis:institution_name","label":"Thesis Institution Name","values":["University of Illinois at Urbana-Champaign"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Molecular quantification","Point-of-care diagnostics","Compact disc based sensing"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["en"]},{"key":"dc:rights","label":"Dc Rights","values":["Copyright 2011 Hassaan Majeed"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["http://hdl.handle.net/2142/26254"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["This thesis aims to document the experimental quantification of molecules on top of a common compact disc (CD) using the ubiquitous and inexpensive technology of a CD drive. To illustrate the concept, glucose is chosen as the target molecule and a colorimetric enzymatic glucose assay is carried out on top of a modified CD. Test strips, similar to the ones used for blood glucose monitoring, are incorporated on top of a CD with audio files burned on it. When a substance containing glucose is dropped onto the strip the resulting change in optical density is proportional to glucose concentration. Using the laser light, optical pickup and the error detection and correction protocol present in all CD drives, this change in optical density and hence the concentration of glucose in the sample are determined quantitatively. The resulting potential “CD glucose meter” can be a cost-effective, mass-deployable, point-of-care tool for rapid blood glucose monitoring and the diagnosis of diabetes. This CD based method for molecular quantification is independent of the type of target molecule and the concept can hence be extended for quantifying other important molecules and carrying out other diagnostic tests in a multiplexed arrangement.","Item withdrawn by Mark Zulauf (zulauf@illinois.edu) on 2011-07-11T15:13:01Z Item was in collections: University of Illinois Theses & Dissertations (ID: 1) No. of bitstreams: 1 Majeed_Hassaan.pdf: 1839184 bytes, checksum: a4adbecce1d058612be731bcf481e69a (MD5)","Made available in DSpace on 2011-08-25T22:21:02Z (GMT). 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When a substance containing glucose is dropped onto the strip the resulting change in optical density is proportional to glucose concentration. Using the laser light, optical pickup and the error detection and correction protocol present in all CD drives, this change in optical density and hence the concentration of glucose in the sample are determined quantitatively. The resulting potential “CD glucose meter” can be a cost-effective, mass-deployable, point-of-care tool for rapid blood glucose monitoring and the diagnosis of diabetes. This CD based method for molecular quantification is independent of the type of target molecule and the concept can hence be extended for quantifying other important molecules and carrying out other diagnostic tests in a multiplexed arrangement.","Item withdrawn by Mark Zulauf (zulauf@illinois.edu) on 2011-07-11T15:13:01Z Item was in collections: University of Illinois Theses & Dissertations (ID: 1) No. of bitstreams: 1 Majeed_Hassaan.pdf: 1839184 bytes, checksum: a4adbecce1d058612be731bcf481e69a (MD5)","Made available in DSpace on 2011-08-25T22:21:02Z (GMT). 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