{"id":{"repo_id":"uiuc","oai_identifier":"oai:www.ideals.illinois.edu:2142/26089"},"canonical_url":"https://search.dev.ndltd.org/etd/uiuc/oai:www.ideals.illinois.edu:2142/26089","repository":{"repo_id":"uiuc","name":"University of Illinois - Urbana-Champaign","base_url":"https://www.ideals.illinois.edu/oai-pmh"},"display":{"title":"Information and the evolution of codon bias","abstract":"The informational properties of biological systems are the subject of much debate and research. I present a general argument in favor of the existence and central importance of information in organisms, followed by a case study of the genetic code (specifically, codon bias) and the translation system from the perspective of information. The codon biases of 831 Bacteria and Archeae are analyzed and modeled as points in a 64-dimensional statistical space. The major results are that (1) codon bias evolution does not follow canonical patterns, and (2) the use of coding space in organsims is a subset of the total possible coding space. These findings imply that codon bias is a unique adaptive mechanism that owes its existence to organisms' use of information in representing genes, and that there is a particularly biological character to the resulting biased coding and information use.","abstract_html":"The informational properties of biological systems are the subject of much debate and research. I present a general argument in favor of the existence and central importance of information in organisms, followed by a case study of the genetic code (specifically, codon bias) and the translation system from the perspective of information. The codon biases of 831 Bacteria and Archeae are analyzed and modeled as points in a 64-dimensional statistical space. The major results are that (1) codon bias evolution does not follow canonical patterns, and (2) the use of coding space in organsims is a subset of the total possible coding space. These findings imply that codon bias is a unique adaptive mechanism that owes its existence to organisms' use of information in representing genes, and that there is a particularly biological character to the resulting biased coding and information use.","abstract_has_math":false,"creators":["Wright, Daniel T."],"institution":"University of Illinois at Urbana-Champaign","degree_name":"Ph.D.","degree_level":"Dissertation","degree_discipline":"Library & Information Science","degree_department":null,"school":null,"contributors":["Luthey-Schulten, Zaida A.","Efron, Miles J.","Gasser, Les","Renear, Allen H."],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2011,"date_issued":"2011-08-25T22:12:33Z","date_published":"2011-08-25T22:12:33Z","updated_at":"2026-07-22T22:25:26Z","subjects":["Information science","Philosophy of information","Evolution","Genetic code","Codon bias","Biological information"],"languages":["en"],"rights":["Copyright 2011 by Daniel T. Wright. All rights reserved."],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"http://hdl.handle.net/2142/26089","outbound_label":"Handle","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["Luthey-Schulten, Zaida A.","Efron, Miles J.","Gasser, Les","Renear, Allen H."]},{"key":"dc:creator","label":"Author","values":["Wright, Daniel T."]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["2011-08-25T22:12:33Z","2011-08"]},{"key":"thesis:degree_discipline","label":"Discipline","values":["Library & Information Science"]},{"key":"thesis:degree_level","label":"Degree Level","values":["Dissertation"]},{"key":"thesis:degree_name","label":"Degree Name","values":["Ph.D."]},{"key":"thesis:institution_name","label":"Thesis Institution Name","values":["University of Illinois at Urbana-Champaign"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Information science","Philosophy of information","Evolution","Genetic code","Codon bias","Biological information"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["en"]},{"key":"dc:rights","label":"Dc Rights","values":["Copyright 2011 by Daniel T. Wright. All rights reserved."]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["http://hdl.handle.net/2142/26089"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["The informational properties of biological systems are the subject of much debate and research. I present a general argument in favor of the existence and central importance of information in organisms, followed by a case study of the genetic code (specifically, codon bias) and the translation system from the perspective of information. The codon biases of 831 Bacteria and Archeae are analyzed and modeled as points in a 64-dimensional statistical space. The major results are that (1) codon bias evolution does not follow canonical patterns, and (2) the use of coding space in organsims is a subset of the total possible coding space. These findings imply that codon bias is a unique adaptive mechanism that owes its existence to organisms' use of information in representing genes, and that there is a particularly biological character to the resulting biased coding and information use.","Item withdrawn by Mark Zulauf (zulauf@illinois.edu) on 2011-07-11T17:29:07Z Item was in collections: University of Illinois Theses & Dissertations (ID: 1) No. of bitstreams: 2 0_wright_daniel_diss_source.zip: 9278099 bytes, checksum: b18efe72b5fcf653a4bf4d2e8cd1f9b1 (MD5) wright_daniel.pdf: 2238891 bytes, checksum: 264a02c435e04e8335227c77f4b5a6a6 (MD5)","Made available in DSpace on 2011-08-25T22:12:33Z (GMT). No. of bitstreams: 3 wright_daniel.pdf: 2238891 bytes, checksum: 264a02c435e04e8335227c77f4b5a6a6 (MD5) license.txt: 4063 bytes, checksum: 088bc2ae1aa9aa7649e49d190cc5684a (MD5) 0_wright_daniel_diss_source.zip: 9278099 bytes, checksum: b18efe72b5fcf653a4bf4d2e8cd1f9b1 (MD5)"]},{"key":"dc:title","label":"Title","values":["Information and the evolution of codon bias"]}]}],"canonical_facts":{"dc:contributor":["Luthey-Schulten, Zaida A.","Efron, Miles J.","Gasser, Les","Renear, Allen H."],"dc:creator":["Wright, Daniel T."],"dc:date":["2011-08-25T22:12:33Z","2011-08"],"dc:description":["The informational properties of biological systems are the subject of much debate and research. I present a general argument in favor of the existence and central importance of information in organisms, followed by a case study of the genetic code (specifically, codon bias) and the translation system from the perspective of information. The codon biases of 831 Bacteria and Archeae are analyzed and modeled as points in a 64-dimensional statistical space. The major results are that (1) codon bias evolution does not follow canonical patterns, and (2) the use of coding space in organsims is a subset of the total possible coding space. These findings imply that codon bias is a unique adaptive mechanism that owes its existence to organisms' use of information in representing genes, and that there is a particularly biological character to the resulting biased coding and information use.","Item withdrawn by Mark Zulauf (zulauf@illinois.edu) on 2011-07-11T17:29:07Z Item was in collections: University of Illinois Theses & Dissertations (ID: 1) No. of bitstreams: 2 0_wright_daniel_diss_source.zip: 9278099 bytes, checksum: b18efe72b5fcf653a4bf4d2e8cd1f9b1 (MD5) wright_daniel.pdf: 2238891 bytes, checksum: 264a02c435e04e8335227c77f4b5a6a6 (MD5)","Made available in DSpace on 2011-08-25T22:12:33Z (GMT). No. of bitstreams: 3 wright_daniel.pdf: 2238891 bytes, checksum: 264a02c435e04e8335227c77f4b5a6a6 (MD5) license.txt: 4063 bytes, checksum: 088bc2ae1aa9aa7649e49d190cc5684a (MD5) 0_wright_daniel_diss_source.zip: 9278099 bytes, checksum: b18efe72b5fcf653a4bf4d2e8cd1f9b1 (MD5)"],"dc:identifier":["http://hdl.handle.net/2142/26089"],"dc:language":["en"],"dc:rights":["Copyright 2011 by Daniel T. Wright. All rights reserved."],"dc:subject":["Information science","Philosophy of information","Evolution","Genetic code","Codon bias","Biological information"],"dc:title":["Information and the evolution of codon bias"],"thesis:degree_discipline":["Library & Information Science"],"thesis:degree_level":["Dissertation"],"thesis:degree_name":["Ph.D."],"thesis:institution_name":["University of Illinois at Urbana-Champaign"]},"updated_at":"2026-07-22T22:25:26Z"}