{"id":{"repo_id":"uiuc","oai_identifier":"oai:www.ideals.illinois.edu:2142/24190"},"canonical_url":"https://search.dev.ndltd.org/etd/uiuc/oai:www.ideals.illinois.edu:2142/24190","repository":{"repo_id":"uiuc","name":"University of Illinois - Urbana-Champaign","base_url":"https://www.ideals.illinois.edu/oai-pmh"},"display":{"title":"Amino acid N-carboxyanhydrides and polypeptides: Controlled polymerization, properties and applications","abstract":"The goal of my Ph.D. research is to develop controlled/living polymerization techniques of α-amino acid N-carboxyanhydrides (NCAs) and synthetic polypeptides based materials. Polypeptides are a class of emerging biomaterials receiving increasing interests for various applications including drug delivery, gene therapy, antimicrobial and tissue engineering. The ring-opening polymerization (ROP) of NCAs has long been demonstrated as a powerful technique for preparation of high molecular weight (MW) synthetic polypeptides in gram scale. We developed a system utilizing organo-silicon amines, namely hexamethyldisilazane (HMDS) and N-trimethylsilyl (N-TMS) amines, for the controlled ROP of various NCAs. Predicable MWs and narrow molecular weight distributions (MWDs) of homo- and block- polypeptides can be prepared via this methodology. Our mechanism study illustrated that the polymerization involves formation of trimethylsilyl carbamate (TMS-CBM) structure at the propagation center. In addition, the system allows facile end group and side-chain functionalization of the polypeptides and integration of NCA ROP with other polymerization techniques such as ring-opening metathesis polymerization (ROMP) to prepare hybrid polypeptides materials. Finally, we discovered a new type of ionic polypeptides with unusual helical stability and demonstrated that they have great potential for gene delivery and siRNA delivery applications.","abstract_html":"The goal of my Ph.D. research is to develop controlled/living polymerization techniques of α-amino acid N-carboxyanhydrides (NCAs) and synthetic polypeptides based materials. Polypeptides are a class of emerging biomaterials receiving increasing interests for various applications including drug delivery, gene therapy, antimicrobial and tissue engineering. The ring-opening polymerization (ROP) of NCAs has long been demonstrated as a powerful technique for preparation of high molecular weight (MW) synthetic polypeptides in gram scale. We developed a system utilizing organo-silicon amines, namely hexamethyldisilazane (HMDS) and N-trimethylsilyl (N-TMS) amines, for the controlled ROP of various NCAs. Predicable MWs and narrow molecular weight distributions (MWDs) of homo- and block- polypeptides can be prepared via this methodology. Our mechanism study illustrated that the polymerization involves formation of trimethylsilyl carbamate (TMS-CBM) structure at the propagation center. In addition, the system allows facile end group and side-chain functionalization of the polypeptides and integration of NCA ROP with other polymerization techniques such as ring-opening metathesis polymerization (ROMP) to prepare hybrid polypeptides materials. Finally, we discovered a new type of ionic polypeptides with unusual helical stability and demonstrated that they have great potential for gene delivery and siRNA delivery applications.","abstract_has_math":false,"creators":["Lu, Hua"],"institution":"University of Illinois at Urbana-Champaign","degree_name":"Ph.D.","degree_level":"Dissertation","degree_discipline":"Materials Science & Engr","degree_department":null,"school":null,"contributors":["Cheng, Jianjun","Braun, Paul V.","Economy, James","Moore, Jeffrey S."],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2011,"date_issued":"2011-05-25T15:02:59Z","date_published":"2011-05-25T15:02:59Z","updated_at":"2026-07-22T22:25:23Z","subjects":["N-carboxyanhydrides (nca)","Polypeptides","Controlled-polymerization","Helix gene-delivery"],"languages":["en"],"rights":["Copyright 2011 Hua Lu"],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"http://hdl.handle.net/2142/24190","outbound_label":"Handle","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["Cheng, Jianjun","Braun, Paul V.","Economy, James","Moore, Jeffrey S."]},{"key":"dc:creator","label":"Author","values":["Lu, Hua"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["2011-05-25T15:02:59Z","2011-05"]},{"key":"thesis:degree_discipline","label":"Discipline","values":["Materials Science & Engr"]},{"key":"thesis:degree_level","label":"Degree Level","values":["Dissertation"]},{"key":"thesis:degree_name","label":"Degree Name","values":["Ph.D."]},{"key":"thesis:institution_name","label":"Thesis Institution Name","values":["University of Illinois at Urbana-Champaign"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["N-carboxyanhydrides (nca)","Polypeptides","Controlled-polymerization","Helix gene-delivery"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["en"]},{"key":"dc:rights","label":"Dc Rights","values":["Copyright 2011 Hua Lu"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["http://hdl.handle.net/2142/24190"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["The goal of my Ph.D. research is to develop controlled/living polymerization techniques of α-amino acid N-carboxyanhydrides (NCAs) and synthetic polypeptides based materials. Polypeptides are a class of emerging biomaterials receiving increasing interests for various applications including drug delivery, gene therapy, antimicrobial and tissue engineering. The ring-opening polymerization (ROP) of NCAs has long been demonstrated as a powerful technique for preparation of high molecular weight (MW) synthetic polypeptides in gram scale. We developed a system utilizing organo-silicon amines, namely hexamethyldisilazane (HMDS) and N-trimethylsilyl (N-TMS) amines, for the controlled ROP of various NCAs. Predicable MWs and narrow molecular weight distributions (MWDs) of homo- and block- polypeptides can be prepared via this methodology. Our mechanism study illustrated that the polymerization involves formation of trimethylsilyl carbamate (TMS-CBM) structure at the propagation center. In addition, the system allows facile end group and side-chain functionalization of the polypeptides and integration of NCA ROP with other polymerization techniques such as ring-opening metathesis polymerization (ROMP) to prepare hybrid polypeptides materials. Finally, we discovered a new type of ionic polypeptides with unusual helical stability and demonstrated that they have great potential for gene delivery and siRNA delivery applications.","Item withdrawn by Mark Zulauf (zulauf@illinois.edu) on 2011-03-08T18:18:33Z Item was in collections: University of Illinois Theses & Dissertations (ID: 1) No. of bitstreams: 1 Lu_Hua.pdf: 3904762 bytes, checksum: dd1e6e362be261874d62a40a46b89338 (MD5)","Made available in DSpace on 2011-05-25T15:02:59Z (GMT). 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The ring-opening polymerization (ROP) of NCAs has long been demonstrated as a powerful technique for preparation of high molecular weight (MW) synthetic polypeptides in gram scale. We developed a system utilizing organo-silicon amines, namely hexamethyldisilazane (HMDS) and N-trimethylsilyl (N-TMS) amines, for the controlled ROP of various NCAs. Predicable MWs and narrow molecular weight distributions (MWDs) of homo- and block- polypeptides can be prepared via this methodology. Our mechanism study illustrated that the polymerization involves formation of trimethylsilyl carbamate (TMS-CBM) structure at the propagation center. In addition, the system allows facile end group and side-chain functionalization of the polypeptides and integration of NCA ROP with other polymerization techniques such as ring-opening metathesis polymerization (ROMP) to prepare hybrid polypeptides materials. Finally, we discovered a new type of ionic polypeptides with unusual helical stability and demonstrated that they have great potential for gene delivery and siRNA delivery applications.","Item withdrawn by Mark Zulauf (zulauf@illinois.edu) on 2011-03-08T18:18:33Z Item was in collections: University of Illinois Theses & Dissertations (ID: 1) No. of bitstreams: 1 Lu_Hua.pdf: 3904762 bytes, checksum: dd1e6e362be261874d62a40a46b89338 (MD5)","Made available in DSpace on 2011-05-25T15:02:59Z (GMT). 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