{"id":{"repo_id":"uiuc","oai_identifier":"oai:www.ideals.illinois.edu:2142/23699"},"canonical_url":"https://search.dev.ndltd.org/etd/uiuc/oai:www.ideals.illinois.edu:2142/23699","repository":{"repo_id":"uiuc","name":"University of Illinois - Urbana-Champaign","base_url":"https://www.ideals.illinois.edu/oai-pmh"},"display":{"title":"New perspectives on dietary soybean effects on serum cholesterol and thyroxin","abstract":"A series of experiments were conducted in mildly hypercholesterolemic men, rats and hamsters to determine the effects of non-protein components from soy on serum cholesterol and thyroid hormones. In mildly hypercholesterolemic males, 20 g soy cotyledon fiber with or without soy protein was not effective in lowering serum cholesterol levels. Individuals consuming soy/cellulose containing muffins had significantly higher free thyroxin index values than when a low-fat, low-cholesterol diet was consumed. In rats, soy isoflavanoids when added to dietary casein caused a significant lowering of LDL cholesterol relative to casein without isoflavanoids. Animals fed casein that had been supplemented with the crude soybean isoflavanoid extract had significantly higher serum total thyroxin and free thyroxin index values than animals that were given non-supplemented casein. The effects by the exogenous isoflavanoids appeared to be modified by the type of dietary protein. Rats fed soybean diets from which isoflavanoids had been removed showed similar cholesterol and thyroid hormone levels to those observed in animals fed soy diets that contained isoflavanoids. In hamsters, animals fed casein diets that were supplemented with a crude soybean isoflavanoid extract at the level normally found in soy isolate had significantly lower total and LDL+VLDL cholesterol concentrations than animals fed casein without isoflavanoids. When the amount of isoflavanoids added to casein was doubled, both total and LDL+VLDL cholesterol concentrations increased and became intermediate between those observed for casein alone and casein plus isoflavanoids added at the level normally found in soy isolate. This pattern of changes in serum cholesterol was not observed for the thyroid hormones. Serum total thyroxin appeared to increase linearly when increasing levels of isoflavanoids were added to either casein or soy. Results from these studies indicate that while dietary soybeans can cause an increased plasma thyroxin, this does not appear to be related to their effects on serum cholesterol.","abstract_html":"A series of experiments were conducted in mildly hypercholesterolemic men, rats and hamsters to determine the effects of non-protein components from soy on serum cholesterol and thyroid hormones. In mildly hypercholesterolemic males, 20 g soy cotyledon fiber with or without soy protein was not effective in lowering serum cholesterol levels. Individuals consuming soy/cellulose containing muffins had significantly higher free thyroxin index values than when a low-fat, low-cholesterol diet was consumed. In rats, soy isoflavanoids when added to dietary casein caused a significant lowering of LDL cholesterol relative to casein without isoflavanoids. Animals fed casein that had been supplemented with the crude soybean isoflavanoid extract had significantly higher serum total thyroxin and free thyroxin index values than animals that were given non-supplemented casein. The effects by the exogenous isoflavanoids appeared to be modified by the type of dietary protein. Rats fed soybean diets from which isoflavanoids had been removed showed similar cholesterol and thyroid hormone levels to those observed in animals fed soy diets that contained isoflavanoids. In hamsters, animals fed casein diets that were supplemented with a crude soybean isoflavanoid extract at the level normally found in soy isolate had significantly lower total and LDL+VLDL cholesterol concentrations than animals fed casein without isoflavanoids. When the amount of isoflavanoids added to casein was doubled, both total and LDL+VLDL cholesterol concentrations increased and became intermediate between those observed for casein alone and casein plus isoflavanoids added at the level normally found in soy isolate. This pattern of changes in serum cholesterol was not observed for the thyroid hormones. Serum total thyroxin appeared to increase linearly when increasing levels of isoflavanoids were added to either casein or soy. Results from these studies indicate that while dietary soybeans can cause an increased plasma thyroxin, this does not appear to be related to their effects on serum cholesterol.","abstract_has_math":false,"creators":["Balmir, Frantzie"],"institution":"University of Illinois at Urbana-Champaign","degree_name":"Ph.D.","degree_level":"Dissertation","degree_discipline":"Biology, Animal Physiology","degree_department":null,"school":null,"contributors":["Potter, S.M."],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2011,"date_issued":"2011-05-07T14:23:47Z","date_published":"2011-05-07T14:23:47Z","updated_at":"2026-07-22T22:25:22Z","subjects":["Biology, Animal Physiology","Chemistry, Biochemistry","Health Sciences, Nutrition"],"languages":["eng"],"rights":["Copyright 1994 Balmir, Frantzie"],"rights_urls":[],"identifier_entries":[{"key":"dc:identifier","label":"Identifier","values":["AAI9512294","(UMI)AAI9512294"],"render_values":[{"text":"AAI9512294","href":null,"code":true},{"text":"(UMI)AAI9512294","href":null,"code":true}]}]},"links":{"outbound_url":"http://hdl.handle.net/2142/23699","outbound_label":"Handle","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["Potter, S.M."]},{"key":"dc:creator","label":"Author","values":["Balmir, Frantzie"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["2011-05-07T14:23:47Z","10000-01-01","1994"]},{"key":"dc:type","label":"Dc Type","values":["text"]},{"key":"thesis:degree_discipline","label":"Discipline","values":["Biology, Animal Physiology","Chemistry, Biochemistry","Health Sciences, Nutrition"]},{"key":"thesis:degree_level","label":"Degree Level","values":["Dissertation"]},{"key":"thesis:degree_name","label":"Degree Name","values":["Ph.D."]},{"key":"thesis:institution_name","label":"Thesis Institution Name","values":["University of Illinois at Urbana-Champaign"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Biology, Animal Physiology","Chemistry, Biochemistry","Health Sciences, Nutrition"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["eng"]},{"key":"dc:rights","label":"Dc Rights","values":["Copyright 1994 Balmir, Frantzie"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["AAI9512294","(UMI)AAI9512294","http://hdl.handle.net/2142/23699"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["A series of experiments were conducted in mildly hypercholesterolemic men, rats and hamsters to determine the effects of non-protein components from soy on serum cholesterol and thyroid hormones. In mildly hypercholesterolemic males, 20 g soy cotyledon fiber with or without soy protein was not effective in lowering serum cholesterol levels. Individuals consuming soy/cellulose containing muffins had significantly higher free thyroxin index values than when a low-fat, low-cholesterol diet was consumed. In rats, soy isoflavanoids when added to dietary casein caused a significant lowering of LDL cholesterol relative to casein without isoflavanoids. Animals fed casein that had been supplemented with the crude soybean isoflavanoid extract had significantly higher serum total thyroxin and free thyroxin index values than animals that were given non-supplemented casein. The effects by the exogenous isoflavanoids appeared to be modified by the type of dietary protein. Rats fed soybean diets from which isoflavanoids had been removed showed similar cholesterol and thyroid hormone levels to those observed in animals fed soy diets that contained isoflavanoids. In hamsters, animals fed casein diets that were supplemented with a crude soybean isoflavanoid extract at the level normally found in soy isolate had significantly lower total and LDL+VLDL cholesterol concentrations than animals fed casein without isoflavanoids. When the amount of isoflavanoids added to casein was doubled, both total and LDL+VLDL cholesterol concentrations increased and became intermediate between those observed for casein alone and casein plus isoflavanoids added at the level normally found in soy isolate. This pattern of changes in serum cholesterol was not observed for the thyroid hormones. Serum total thyroxin appeared to increase linearly when increasing levels of isoflavanoids were added to either casein or soy. Results from these studies indicate that while dietary soybeans can cause an increased plasma thyroxin, this does not appear to be related to their effects on serum cholesterol.","Made available in DSpace on 2011-05-07T14:23:47Z (GMT). No. of bitstreams: 2 license.txt: 4922 bytes, checksum: 910b249b4beec47e7ab768910c8f966f (MD5) 9512294.pdf: 4091731 bytes, checksum: 5301bff378318c7bab9512f6053285e5 (MD5) Previous issue date: 1994","Item marked as restricted to the 'UIUC Users [automated]' Group (id=2) by Howard Ding (hding2@illinois.edu) on 2011-05-07T15:06:15Z Item is restricted indefinitely.","Restriction data tranferred 2014-07-01T11:31:47-05:00 Original Data Group with Access UIUC Users [automated] Release Date: none Reason: ETDs are only available to UIUC Users without author permission","ETDs are only available to UIUC Users without author permission","U of I Only"]},{"key":"dc:title","label":"Title","values":["New perspectives on dietary soybean effects on serum cholesterol and thyroxin"]}]}],"canonical_facts":{"dc:contributor":["Potter, S.M."],"dc:creator":["Balmir, Frantzie"],"dc:date":["2011-05-07T14:23:47Z","10000-01-01","1994"],"dc:description":["A series of experiments were conducted in mildly hypercholesterolemic men, rats and hamsters to determine the effects of non-protein components from soy on serum cholesterol and thyroid hormones. In mildly hypercholesterolemic males, 20 g soy cotyledon fiber with or without soy protein was not effective in lowering serum cholesterol levels. Individuals consuming soy/cellulose containing muffins had significantly higher free thyroxin index values than when a low-fat, low-cholesterol diet was consumed. In rats, soy isoflavanoids when added to dietary casein caused a significant lowering of LDL cholesterol relative to casein without isoflavanoids. Animals fed casein that had been supplemented with the crude soybean isoflavanoid extract had significantly higher serum total thyroxin and free thyroxin index values than animals that were given non-supplemented casein. The effects by the exogenous isoflavanoids appeared to be modified by the type of dietary protein. Rats fed soybean diets from which isoflavanoids had been removed showed similar cholesterol and thyroid hormone levels to those observed in animals fed soy diets that contained isoflavanoids. In hamsters, animals fed casein diets that were supplemented with a crude soybean isoflavanoid extract at the level normally found in soy isolate had significantly lower total and LDL+VLDL cholesterol concentrations than animals fed casein without isoflavanoids. When the amount of isoflavanoids added to casein was doubled, both total and LDL+VLDL cholesterol concentrations increased and became intermediate between those observed for casein alone and casein plus isoflavanoids added at the level normally found in soy isolate. This pattern of changes in serum cholesterol was not observed for the thyroid hormones. Serum total thyroxin appeared to increase linearly when increasing levels of isoflavanoids were added to either casein or soy. Results from these studies indicate that while dietary soybeans can cause an increased plasma thyroxin, this does not appear to be related to their effects on serum cholesterol.","Made available in DSpace on 2011-05-07T14:23:47Z (GMT). No. of bitstreams: 2 license.txt: 4922 bytes, checksum: 910b249b4beec47e7ab768910c8f966f (MD5) 9512294.pdf: 4091731 bytes, checksum: 5301bff378318c7bab9512f6053285e5 (MD5) Previous issue date: 1994","Item marked as restricted to the 'UIUC Users [automated]' Group (id=2) by Howard Ding (hding2@illinois.edu) on 2011-05-07T15:06:15Z Item is restricted indefinitely.","Restriction data tranferred 2014-07-01T11:31:47-05:00 Original Data Group with Access UIUC Users [automated] Release Date: none Reason: ETDs are only available to UIUC Users without author permission","ETDs are only available to UIUC Users without author permission","U of I Only"],"dc:identifier":["AAI9512294","(UMI)AAI9512294","http://hdl.handle.net/2142/23699"],"dc:language":["eng"],"dc:rights":["Copyright 1994 Balmir, Frantzie"],"dc:subject":["Biology, Animal Physiology","Chemistry, Biochemistry","Health Sciences, Nutrition"],"dc:title":["New perspectives on dietary soybean effects on serum cholesterol and thyroxin"],"dc:type":["text"],"thesis:degree_discipline":["Biology, Animal Physiology","Chemistry, Biochemistry","Health Sciences, Nutrition"],"thesis:degree_level":["Dissertation"],"thesis:degree_name":["Ph.D."],"thesis:institution_name":["University of Illinois at Urbana-Champaign"]},"updated_at":"2026-07-22T22:25:22Z"}