{"id":{"repo_id":"uiuc","oai_identifier":"oai:www.ideals.illinois.edu:2142/23106"},"canonical_url":"https://search.dev.ndltd.org/etd/uiuc/oai:www.ideals.illinois.edu:2142/23106","repository":{"repo_id":"uiuc","name":"University of Illinois - Urbana-Champaign","base_url":"https://www.ideals.illinois.edu/oai-pmh"},"display":{"title":"The morphology and function of Peyer's patches in the dog","abstract":"Canine Peyer's patches (PPs) were characterized by immunohistology, alkaline phosphatase histochemistry and electron microscopy. Duodenal PPs were very similar to jejunal PPs, except for the consistent presence of intrafollicular invaginations of the dome epithelium. The single ileal PP had small domes and sparsely populated interfollicular areas. Whereas the dome epithelium of proximal PPs consisted of alkaline phosphates positive enterocytes and scattered M cells with low alkaline phosphatase activity, ileal dome epithelia predominantly consisted of M cells and few enterocytes. The domes of PPs contained numerous IgG plasma cells and a few or moderate number of IgA plasma cells.","abstract_html":"Canine Peyer's patches (PPs) were characterized by immunohistology, alkaline phosphatase histochemistry and electron microscopy. Duodenal PPs were very similar to jejunal PPs, except for the consistent presence of intrafollicular invaginations of the dome epithelium. The single ileal PP had small domes and sparsely populated interfollicular areas. Whereas the dome epithelium of proximal PPs consisted of alkaline phosphates positive enterocytes and scattered M cells with low alkaline phosphatase activity, ileal dome epithelia predominantly consisted of M cells and few enterocytes. The domes of PPs contained numerous IgG plasma cells and a few or moderate number of IgA plasma cells.","abstract_has_math":false,"creators":["HogenEsch, Harm"],"institution":"University of Illinois at Urbana-Champaign","degree_name":"Ph.D.","degree_level":"Dissertation","degree_discipline":"Pathobiology","degree_department":null,"school":null,"contributors":["Felsburg, P.J."],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2011,"date_issued":"2011-05-07T14:02:24Z","date_published":"2011-05-07T14:02:24Z","updated_at":"2026-07-22T22:25:21Z","subjects":["Biology, Veterinary Science","Health Sciences, Immunology"],"languages":["eng"],"rights":["Copyright 1989 HogenEsch, Harm"],"rights_urls":[],"identifier_entries":[{"key":"dc:identifier","label":"Identifier","values":["AAI9010888","(UMI)AAI9010888"],"render_values":[{"text":"AAI9010888","href":null,"code":true},{"text":"(UMI)AAI9010888","href":null,"code":true}]}]},"links":{"outbound_url":"http://hdl.handle.net/2142/23106","outbound_label":"Handle","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["Felsburg, P.J."]},{"key":"dc:creator","label":"Author","values":["HogenEsch, Harm"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["2011-05-07T14:02:24Z","10000-01-01","1989"]},{"key":"dc:type","label":"Dc Type","values":["text"]},{"key":"thesis:degree_discipline","label":"Discipline","values":["Pathobiology"]},{"key":"thesis:degree_level","label":"Degree Level","values":["Dissertation"]},{"key":"thesis:degree_name","label":"Degree Name","values":["Ph.D."]},{"key":"thesis:institution_name","label":"Thesis Institution Name","values":["University of Illinois at Urbana-Champaign"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Biology, Veterinary Science","Health Sciences, Immunology"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["eng"]},{"key":"dc:rights","label":"Dc Rights","values":["Copyright 1989 HogenEsch, Harm"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["AAI9010888","(UMI)AAI9010888","http://hdl.handle.net/2142/23106"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["Canine Peyer's patches (PPs) were characterized by immunohistology, alkaline phosphatase histochemistry and electron microscopy. Duodenal PPs were very similar to jejunal PPs, except for the consistent presence of intrafollicular invaginations of the dome epithelium. The single ileal PP had small domes and sparsely populated interfollicular areas. Whereas the dome epithelium of proximal PPs consisted of alkaline phosphates positive enterocytes and scattered M cells with low alkaline phosphatase activity, ileal dome epithelia predominantly consisted of M cells and few enterocytes. The domes of PPs contained numerous IgG plasma cells and a few or moderate number of IgA plasma cells.","The development of PPs in the dog began before birth, but germinal centers and significant mitotic activity were not observed until after 1 week post partum. The ileal PP reached a large size in 4-6 months old dogs and rapidly involuted afterwards.","Cell suspensions from proximal and ileal PPs contained approximately 50% B cells, but ileal PPs contained more mIgM$+$ cells and fewer mIgA$+$ cells. Fewer T cells were present in the ileal PP. Cells from proximal PPs secreted more IgA than cells from other lymphoid tissues in vitro. The ileal PP secreted very little IgG and IgA, but more IgM than proximal PPs.","IgA, but not IgG and IgM, secretion by pokeweed mitogen-stimulated cells from proximal PPs was further enhanced by addition of concanvalin A (ConA) to the cultures, suggesting the presence of isotype-specific T cells. This effect of ConA was not observed in other lymphoid tissues. ConA-activated T cells were expanded in the presence of interleukin-2 and cloned by limiting dilution. One clone induced a large secretion of IgA by PWM stimulated B cells, isolated by panning from peripheral blood or peripheral lymph nodes.","It was concluded that proximal PPs of dogs are important in IgA production; that PP T cells can increase IgA production; and that the ileal PP is morphologically and functionally different from proximal PPs and may be a site of B cell amplification in the dog.","Made available in DSpace on 2011-05-07T14:02:24Z (GMT). No. of bitstreams: 2 license.txt: 4922 bytes, checksum: 910b249b4beec47e7ab768910c8f966f (MD5) 9010888.pdf: 6292268 bytes, checksum: 15f03b3e79124b4fc9826cdc4f41d32b (MD5) Previous issue date: 1989","Item marked as restricted to the 'UIUC Users [automated]' Group (id=2) by Howard Ding (hding2@illinois.edu) on 2011-05-07T15:02:13Z Item is restricted indefinitely.","Restriction data tranferred 2014-07-01T11:29:34-05:00 Original Data Group with Access UIUC Users [automated] Release Date: none Reason: ETDs are only available to UIUC Users without author permission","ETDs are only available to UIUC Users without author permission","U of I Only"]},{"key":"dc:title","label":"Title","values":["The morphology and function of Peyer's patches in the dog"]}]}],"canonical_facts":{"dc:contributor":["Felsburg, P.J."],"dc:creator":["HogenEsch, Harm"],"dc:date":["2011-05-07T14:02:24Z","10000-01-01","1989"],"dc:description":["Canine Peyer's patches (PPs) were characterized by immunohistology, alkaline phosphatase histochemistry and electron microscopy. Duodenal PPs were very similar to jejunal PPs, except for the consistent presence of intrafollicular invaginations of the dome epithelium. The single ileal PP had small domes and sparsely populated interfollicular areas. Whereas the dome epithelium of proximal PPs consisted of alkaline phosphates positive enterocytes and scattered M cells with low alkaline phosphatase activity, ileal dome epithelia predominantly consisted of M cells and few enterocytes. The domes of PPs contained numerous IgG plasma cells and a few or moderate number of IgA plasma cells.","The development of PPs in the dog began before birth, but germinal centers and significant mitotic activity were not observed until after 1 week post partum. The ileal PP reached a large size in 4-6 months old dogs and rapidly involuted afterwards.","Cell suspensions from proximal and ileal PPs contained approximately 50% B cells, but ileal PPs contained more mIgM$+$ cells and fewer mIgA$+$ cells. Fewer T cells were present in the ileal PP. Cells from proximal PPs secreted more IgA than cells from other lymphoid tissues in vitro. The ileal PP secreted very little IgG and IgA, but more IgM than proximal PPs.","IgA, but not IgG and IgM, secretion by pokeweed mitogen-stimulated cells from proximal PPs was further enhanced by addition of concanvalin A (ConA) to the cultures, suggesting the presence of isotype-specific T cells. This effect of ConA was not observed in other lymphoid tissues. ConA-activated T cells were expanded in the presence of interleukin-2 and cloned by limiting dilution. One clone induced a large secretion of IgA by PWM stimulated B cells, isolated by panning from peripheral blood or peripheral lymph nodes.","It was concluded that proximal PPs of dogs are important in IgA production; that PP T cells can increase IgA production; and that the ileal PP is morphologically and functionally different from proximal PPs and may be a site of B cell amplification in the dog.","Made available in DSpace on 2011-05-07T14:02:24Z (GMT). No. of bitstreams: 2 license.txt: 4922 bytes, checksum: 910b249b4beec47e7ab768910c8f966f (MD5) 9010888.pdf: 6292268 bytes, checksum: 15f03b3e79124b4fc9826cdc4f41d32b (MD5) Previous issue date: 1989","Item marked as restricted to the 'UIUC Users [automated]' Group (id=2) by Howard Ding (hding2@illinois.edu) on 2011-05-07T15:02:13Z Item is restricted indefinitely.","Restriction data tranferred 2014-07-01T11:29:34-05:00 Original Data Group with Access UIUC Users [automated] Release Date: none Reason: ETDs are only available to UIUC Users without author permission","ETDs are only available to UIUC Users without author permission","U of I Only"],"dc:identifier":["AAI9010888","(UMI)AAI9010888","http://hdl.handle.net/2142/23106"],"dc:language":["eng"],"dc:rights":["Copyright 1989 HogenEsch, Harm"],"dc:subject":["Biology, Veterinary Science","Health Sciences, Immunology"],"dc:title":["The morphology and function of Peyer's patches in the dog"],"dc:type":["text"],"thesis:degree_discipline":["Pathobiology"],"thesis:degree_level":["Dissertation"],"thesis:degree_name":["Ph.D."],"thesis:institution_name":["University of Illinois at Urbana-Champaign"]},"updated_at":"2026-07-22T22:25:21Z"}