Biochemical and chemical studies of the components involved in the final step of methane formation in Methanobacterium
The final step of methane formation in Methanobacterium thermoautotrophicum is a reductive demethylation of 2-(methylthio)ethanesulfonic acid (CH$\sb3$-S-CoM) with reducing equivalents from 7-(mercaptoheptanoyl)-L-threonine O$\sp3$-phosphate (HS-HTP). The enzyme that catalyzes this step is the CH$\sb3$-S-CoM reductase. Bound to the enzyme (non-covalently) is the prosthetic group, native coenzyme F430, a unique nickel-containing tetrapyrrole.
Biology, Microbiology, Chemistry, Biochemistry
University of Illinois - Urbana-Champaign
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University of Illinois at Urbana-Champaign