Transcriptional regulation of CYP6B1v3, a furanocoumarin-inducible P450 gene from black swallowtail (Papilio polyxenes)
Black swallowtail (Papilio polyxenes) is an oligophagous insect feeding exclusively on plant species which contain toxic furanocoumarins. P. polyxenes owes its tolerance to furanocoumarins to at least one cytochrome P450 isozyme, CYP6B1, which is capable of metabolizing linear furanocoumarins at high efficiency. CYP6B1 is autoregulated as it is transcriptionally induced by xanthotoxin, which the protein is capable of metabolizing.
Biology, Molecular, Biology, Entomology, Chemistry, Biochemistry
University of Illinois - Urbana-Champaign
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University of Illinois at Urbana-Champaign