{"id":{"repo_id":"uiuc","oai_identifier":"oai:www.ideals.illinois.edu:2142/21848"},"canonical_url":"https://search.dev.ndltd.org/etd/uiuc/oai:www.ideals.illinois.edu:2142/21848","repository":{"repo_id":"uiuc","name":"University of Illinois - Urbana-Champaign","base_url":"https://www.ideals.illinois.edu/oai-pmh"},"display":{"title":"Characterization and pharmacological analysis of electrical activity in the small intestine of fasting cat","abstract":"Electrical activity of smooth muscle of the small intestine in fasting cat was studied. 18 cats were each implanted with a set of 4-6 bipolar electrodes positioned at regular intervals along the distal half of the small intestine.","abstract_html":"Electrical activity of smooth muscle of the small intestine in fasting cat was studied. 18 cats were each implanted with a set of 4-6 bipolar electrodes positioned at regular intervals along the distal half of the small intestine.","abstract_has_math":false,"creators":["De Vos, Wayne Calvin"],"institution":"University of Illinois at Urbana-Champaign","degree_name":"Ph.D.","degree_level":"Dissertation","degree_discipline":"Physiology","degree_department":null,"school":null,"contributors":["Prosser, C. Ladd"],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2011,"date_issued":"2011-05-07T13:21:00Z","date_published":"2011-05-07T13:21:00Z","updated_at":"2026-07-22T22:25:18Z","subjects":["Biology, Animal Physiology"],"languages":["eng"],"rights":["Copyright 1989 De Vos, Wayne Calvin"],"rights_urls":[],"identifier_entries":[{"key":"dc:identifier","label":"Identifier","values":["AAI9010845","(UMI)AAI9010845"],"render_values":[{"text":"AAI9010845","href":null,"code":true},{"text":"(UMI)AAI9010845","href":null,"code":true}]}]},"links":{"outbound_url":"http://hdl.handle.net/2142/21848","outbound_label":"Handle","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["Prosser, C. Ladd"]},{"key":"dc:creator","label":"Author","values":["De Vos, Wayne Calvin"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["2011-05-07T13:21:00Z","10000-01-01","1989"]},{"key":"dc:type","label":"Dc Type","values":["text"]},{"key":"thesis:degree_discipline","label":"Discipline","values":["Physiology"]},{"key":"thesis:degree_level","label":"Degree Level","values":["Dissertation"]},{"key":"thesis:degree_name","label":"Degree Name","values":["Ph.D."]},{"key":"thesis:institution_name","label":"Thesis Institution Name","values":["University of Illinois at Urbana-Champaign"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Biology, Animal Physiology"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["eng"]},{"key":"dc:rights","label":"Dc Rights","values":["Copyright 1989 De Vos, Wayne Calvin"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["AAI9010845","(UMI)AAI9010845","http://hdl.handle.net/2142/21848"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["Electrical activity of smooth muscle of the small intestine in fasting cat was studied. 18 cats were each implanted with a set of 4-6 bipolar electrodes positioned at regular intervals along the distal half of the small intestine.","\"Results. During the fasting state all cats exhibited the \"\"migrating spike complex\"\" (MSC), an intense prolonged band of spike potentials not associated with slow waves, which appeared with great variability at approximately hourly intervals. The MSC migrated at a rate between 1-8 mm/sec, accelerating as it moves distally, and exhibits a refractory nature. The MSC was associated with an intense, prolonged contraction. Pharmacological analysis using IV infusion of neural receptor antagonists and/or agonists showed that nonspecific blockade of nicotinic or muscarinic receptors inhibited the propagation of the MSC. Infusion of agents specific for muscarinic-receptor subtypes showed that while blockade of m$\\sb2$-receptors inhibited MSC propagation, blockade of m$\\sb1$-receptors was followed by a significant, dose-dependent increase in MSC activity; stimulation of m$\\sb1$-receptors blocked MSC propagation. Infusion of $\\alpha$-adrenoceptor subtype specific agents showed that both $\\alpha\\sb1$- and $\\alpha\\sb2$-adrenoceptors are involved in the inhibitory control of MSC activity, while $\\beta$-adrenoceptors do not appear to play a significant role in MSC activity. Also present during the fasting state in 9/18 cats was an activity characterized by a significant decrease in slow wave frequency and amplitude and a concomitant increase in spike potential duration and amplitude. These periods of \"\"low frequency slow waves/giant spike bursts\"\" (LFSW/GSB) lasted from 1-4 hours, were terminated by feeding, and were not associated with any apparent distress in the animal. Pharmacological analysis showed that periods of LFSW/GSB occurred significantly more often following infusion of an m$\\sb1$-muscarinic receptor antagonist compared to saline; m$\\sb1$-receptor stimulation or m$\\sb2$-receptor blockade was followed by a transient inhibition of GSB activity. Blockade of nicotinic receptors inhibited LFSW/GSB activity, while $\\alpha$-adrenoceptor blockade had no effect. Conclusion. The small intestine of the fasting cat exhibits at least two patterns of myoelectric activity, the MSC and the LFSW/GSB, which, unlike slow waves and spike bursts, require the integrity of the enteric nervous system for their expression and regulation. Neither activity has been reported from in vitro recordings.\"","Made available in DSpace on 2011-05-07T13:21:00Z (GMT). No. of bitstreams: 2 license.txt: 4922 bytes, checksum: 910b249b4beec47e7ab768910c8f966f (MD5) 9010845.pdf: 8359962 bytes, checksum: addd1e4029035674f0bea2a87f8472f6 (MD5) Previous issue date: 1989","Item marked as restricted to the 'UIUC Users [automated]' Group (id=2) by Howard Ding (hding2@illinois.edu) on 2011-05-07T14:53:36Z Item is restricted indefinitely.","Restriction data tranferred 2014-07-01T11:24:49-05:00 Original Data Group with Access UIUC Users [automated] Release Date: none Reason: ETDs are only available to UIUC Users without author permission","ETDs are only available to UIUC Users without author permission","U of I Only"]},{"key":"dc:title","label":"Title","values":["Characterization and pharmacological analysis of electrical activity in the small intestine of fasting cat"]}]}],"canonical_facts":{"dc:contributor":["Prosser, C. Ladd"],"dc:creator":["De Vos, Wayne Calvin"],"dc:date":["2011-05-07T13:21:00Z","10000-01-01","1989"],"dc:description":["Electrical activity of smooth muscle of the small intestine in fasting cat was studied. 18 cats were each implanted with a set of 4-6 bipolar electrodes positioned at regular intervals along the distal half of the small intestine.","\"Results. During the fasting state all cats exhibited the \"\"migrating spike complex\"\" (MSC), an intense prolonged band of spike potentials not associated with slow waves, which appeared with great variability at approximately hourly intervals. The MSC migrated at a rate between 1-8 mm/sec, accelerating as it moves distally, and exhibits a refractory nature. The MSC was associated with an intense, prolonged contraction. Pharmacological analysis using IV infusion of neural receptor antagonists and/or agonists showed that nonspecific blockade of nicotinic or muscarinic receptors inhibited the propagation of the MSC. Infusion of agents specific for muscarinic-receptor subtypes showed that while blockade of m$\\sb2$-receptors inhibited MSC propagation, blockade of m$\\sb1$-receptors was followed by a significant, dose-dependent increase in MSC activity; stimulation of m$\\sb1$-receptors blocked MSC propagation. Infusion of $\\alpha$-adrenoceptor subtype specific agents showed that both $\\alpha\\sb1$- and $\\alpha\\sb2$-adrenoceptors are involved in the inhibitory control of MSC activity, while $\\beta$-adrenoceptors do not appear to play a significant role in MSC activity. Also present during the fasting state in 9/18 cats was an activity characterized by a significant decrease in slow wave frequency and amplitude and a concomitant increase in spike potential duration and amplitude. These periods of \"\"low frequency slow waves/giant spike bursts\"\" (LFSW/GSB) lasted from 1-4 hours, were terminated by feeding, and were not associated with any apparent distress in the animal. Pharmacological analysis showed that periods of LFSW/GSB occurred significantly more often following infusion of an m$\\sb1$-muscarinic receptor antagonist compared to saline; m$\\sb1$-receptor stimulation or m$\\sb2$-receptor blockade was followed by a transient inhibition of GSB activity. Blockade of nicotinic receptors inhibited LFSW/GSB activity, while $\\alpha$-adrenoceptor blockade had no effect. Conclusion. The small intestine of the fasting cat exhibits at least two patterns of myoelectric activity, the MSC and the LFSW/GSB, which, unlike slow waves and spike bursts, require the integrity of the enteric nervous system for their expression and regulation. Neither activity has been reported from in vitro recordings.\"","Made available in DSpace on 2011-05-07T13:21:00Z (GMT). No. of bitstreams: 2 license.txt: 4922 bytes, checksum: 910b249b4beec47e7ab768910c8f966f (MD5) 9010845.pdf: 8359962 bytes, checksum: addd1e4029035674f0bea2a87f8472f6 (MD5) Previous issue date: 1989","Item marked as restricted to the 'UIUC Users [automated]' Group (id=2) by Howard Ding (hding2@illinois.edu) on 2011-05-07T14:53:36Z Item is restricted indefinitely.","Restriction data tranferred 2014-07-01T11:24:49-05:00 Original Data Group with Access UIUC Users [automated] Release Date: none Reason: ETDs are only available to UIUC Users without author permission","ETDs are only available to UIUC Users without author permission","U of I Only"],"dc:identifier":["AAI9010845","(UMI)AAI9010845","http://hdl.handle.net/2142/21848"],"dc:language":["eng"],"dc:rights":["Copyright 1989 De Vos, Wayne Calvin"],"dc:subject":["Biology, Animal Physiology"],"dc:title":["Characterization and pharmacological analysis of electrical activity in the small intestine of fasting cat"],"dc:type":["text"],"thesis:degree_discipline":["Physiology"],"thesis:degree_level":["Dissertation"],"thesis:degree_name":["Ph.D."],"thesis:institution_name":["University of Illinois at Urbana-Champaign"]},"updated_at":"2026-07-22T22:25:18Z"}