{"id":{"repo_id":"uiuc","oai_identifier":"oai:www.ideals.illinois.edu:2142/21787"},"canonical_url":"https://search.dev.ndltd.org/etd/uiuc/oai:www.ideals.illinois.edu:2142/21787","repository":{"repo_id":"uiuc","name":"University of Illinois - Urbana-Champaign","base_url":"https://www.ideals.illinois.edu/oai-pmh"},"display":{"title":"Design, synthesis, and evaluation of selectors and stationary phases for improved liquid chromatographic separations","abstract":"Finally, the rational design of an improved selector and stationary phase for the carbon cluster buckminsterfullerene (C$\\sb{60}$) is described. A tripodal selector containing three $\\pi$-acidic aromatic rings for simultaneous multipoint interaction with the spherical analyte molecule was immobilized on silica to afford a stationary phase displaying a high degree of retention for buckminsterfullerene, and a large separation factor for separation of the C$\\sb{60}$/C$\\sb{70}$ mixture.","abstract_html":"Finally, the rational design of an improved selector and stationary phase for the carbon cluster buckminsterfullerene (C$\\sb{60}$) is described. A tripodal selector containing three <span class=\"etd-inline-math\">&pi;</span>-acidic aromatic rings for simultaneous multipoint interaction with the spherical analyte molecule was immobilized on silica to afford a stationary phase displaying a high degree of retention for buckminsterfullerene, and a large separation factor for separation of the C$\\sb{60}$/C$\\sb{70}$ mixture.","abstract_has_math":true,"creators":["Welch, Christopher J."],"institution":"University of Illinois at Urbana-Champaign","degree_name":"Ph.D.","degree_level":"Dissertation","degree_discipline":"Chemistry","degree_department":null,"school":null,"contributors":["Pirkle, William H."],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2011,"date_issued":"2011-05-07T13:19:08Z","date_published":"2011-05-07T13:19:08Z","updated_at":"2026-07-22T22:25:18Z","subjects":["Chemistry, Analytical"],"languages":["eng"],"rights":["Copyright 1992 Welch, Christopher J."],"rights_urls":[],"identifier_entries":[{"key":"dc:identifier","label":"Identifier","values":["AAI9236621","(UMI)AAI9236621"],"render_values":[{"text":"AAI9236621","href":null,"code":true},{"text":"(UMI)AAI9236621","href":null,"code":true}]}]},"links":{"outbound_url":"http://hdl.handle.net/2142/21787","outbound_label":"Handle","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["Pirkle, William H."]},{"key":"dc:creator","label":"Author","values":["Welch, Christopher J."]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["2011-05-07T13:19:08Z","10000-01-01","1992"]},{"key":"dc:type","label":"Dc Type","values":["text"]},{"key":"thesis:degree_discipline","label":"Discipline","values":["Chemistry"]},{"key":"thesis:degree_level","label":"Degree Level","values":["Dissertation"]},{"key":"thesis:degree_name","label":"Degree Name","values":["Ph.D."]},{"key":"thesis:institution_name","label":"Thesis Institution Name","values":["University of Illinois at Urbana-Champaign"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Chemistry, Analytical"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["eng"]},{"key":"dc:rights","label":"Dc Rights","values":["Copyright 1992 Welch, Christopher J."]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["AAI9236621","(UMI)AAI9236621","http://hdl.handle.net/2142/21787"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["Finally, the rational design of an improved selector and stationary phase for the carbon cluster buckminsterfullerene (C$\\sb{60}$) is described. A tripodal selector containing three $\\pi$-acidic aromatic rings for simultaneous multipoint interaction with the spherical analyte molecule was immobilized on silica to afford a stationary phase displaying a high degree of retention for buckminsterfullerene, and a large separation factor for separation of the C$\\sb{60}$/C$\\sb{70}$ mixture.","In this study a diverse array of research projects are presented, all having to do with the development of selectors and stationary phases for improved liquid chromatographic separations. Apart from the introductory material, two main topics are addressed: (1) the role of non-specific adsorption in chromatographic separations, and (2) the synthesis of selectors designed for recognition of particular analyte molecules.","In the introductory part of the thesis the use of 1,3,5-tri-t-butylbenzene as an improved void volume marker for several chiral stationary phases (CSPs) is described, as is a thermodynamic study investigating the role of solvation in a well characterized chiral recognition system.","The role of non-specific adsorption in chromatographic separations has been addressed for both the analyte and the stationary phase. A study of the effect of superfluous remote polar functionality on chiral recognition shows that polar groups not required in the chiral recognition process can have a deleterious effect on enantiomer separations by increasing retention and sometimes reducing enantioselectivity. The preparation of CSPs in which nonessential interaction sites have been eliminated leads to CSPs showing reduced retention and increased enantioselectivity.","\"An improved CSP designed for the non-steroidal anti-inflammatory drug, naproxen, is described in-five different studies. A \"\"reciprocal\"\" approach was used in this study, (S)-naproxen being immobilized to produce a CSP which was used to screen potential naproxen selectors. This study revealed several key features important for the enantioselective recognition of naproxen, which were incorporated inio a novel selector and CSP displaying a high degree of enantioselectivity for underivatized naproxen. The underivatized enantiomers of a number of related drugs such as ibuprofen, ketoprofen, etc. are easily separable using this CSP.\"","Made available in DSpace on 2011-05-07T13:19:08Z (GMT). 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A tripodal selector containing three $\\pi$-acidic aromatic rings for simultaneous multipoint interaction with the spherical analyte molecule was immobilized on silica to afford a stationary phase displaying a high degree of retention for buckminsterfullerene, and a large separation factor for separation of the C$\\sb{60}$/C$\\sb{70}$ mixture.","In this study a diverse array of research projects are presented, all having to do with the development of selectors and stationary phases for improved liquid chromatographic separations. Apart from the introductory material, two main topics are addressed: (1) the role of non-specific adsorption in chromatographic separations, and (2) the synthesis of selectors designed for recognition of particular analyte molecules.","In the introductory part of the thesis the use of 1,3,5-tri-t-butylbenzene as an improved void volume marker for several chiral stationary phases (CSPs) is described, as is a thermodynamic study investigating the role of solvation in a well characterized chiral recognition system.","The role of non-specific adsorption in chromatographic separations has been addressed for both the analyte and the stationary phase. A study of the effect of superfluous remote polar functionality on chiral recognition shows that polar groups not required in the chiral recognition process can have a deleterious effect on enantiomer separations by increasing retention and sometimes reducing enantioselectivity. The preparation of CSPs in which nonessential interaction sites have been eliminated leads to CSPs showing reduced retention and increased enantioselectivity.","\"An improved CSP designed for the non-steroidal anti-inflammatory drug, naproxen, is described in-five different studies. A \"\"reciprocal\"\" approach was used in this study, (S)-naproxen being immobilized to produce a CSP which was used to screen potential naproxen selectors. This study revealed several key features important for the enantioselective recognition of naproxen, which were incorporated inio a novel selector and CSP displaying a high degree of enantioselectivity for underivatized naproxen. The underivatized enantiomers of a number of related drugs such as ibuprofen, ketoprofen, etc. are easily separable using this CSP.\"","Made available in DSpace on 2011-05-07T13:19:08Z (GMT). No. of bitstreams: 2 license.txt: 4922 bytes, checksum: 910b249b4beec47e7ab768910c8f966f (MD5) 9236621.pdf: 8353842 bytes, checksum: dfd23f8223156e717e4dc29c2857b1e9 (MD5) Previous issue date: 1992","Item marked as restricted to the 'UIUC Users [automated]' Group (id=2) by Howard Ding (hding2@illinois.edu) on 2011-05-07T14:53:12Z Item is restricted indefinitely.","Restriction data tranferred 2014-07-01T11:24:35-05:00 Original Data Group with Access UIUC Users [automated] Release Date: none Reason: ETDs are only available to UIUC Users without author permission","ETDs are only available to UIUC Users without author permission","U of I Only"],"dc:identifier":["AAI9236621","(UMI)AAI9236621","http://hdl.handle.net/2142/21787"],"dc:language":["eng"],"dc:rights":["Copyright 1992 Welch, Christopher J."],"dc:subject":["Chemistry, Analytical"],"dc:title":["Design, synthesis, and evaluation of selectors and stationary phases for improved liquid chromatographic separations"],"dc:type":["text"],"thesis:degree_discipline":["Chemistry"],"thesis:degree_level":["Dissertation"],"thesis:degree_name":["Ph.D."],"thesis:institution_name":["University of Illinois at Urbana-Champaign"]},"updated_at":"2026-07-22T22:25:18Z"}