{"id":{"repo_id":"uiuc","oai_identifier":"oai:www.ideals.illinois.edu:2142/21476"},"canonical_url":"https://search.dev.ndltd.org/etd/uiuc/oai:www.ideals.illinois.edu:2142/21476","repository":{"repo_id":"uiuc","name":"University of Illinois - Urbana-Champaign","base_url":"https://www.ideals.illinois.edu/oai-pmh"},"display":{"title":"Effects of acute and chronic exercise on the activities of hepatic lipogenic enzymes in rats","abstract":"Effects of acute exercise and chronic exercise training on activities of five hepatic lipogenic enzymes were studied in rats fed different high-carbohydrate diets. In Study 1, ATP citrate lyase (CL), pyruvate kinase (PK), and fatty acid synthase (FAS) activities were greater in rats fed a high-fructose diet than in rats fed high-glucose or high-cornstarch diets. Exercise decreased CL, PK, FAS, and glucose-6-phosphate dehydrogenase (G6PDH) activities, especially in fructose-fed rats. Study 2 examined the time course of dietary induction of enzymes in fasted/refed rats, and the inhibitory effect of exhaustive exercise on induction. Fasting suppressed all activities to minimal levels. FAS and PK activities increased between 4 and 8 hours of refeeding, then plateaued and were greater in fructose versus cornstarch rats. Activities of malic enzyme, CL, and G6PDH peaked after 48 hours; fructose-fed rats had higher activities than cornstarch-fed rats. Exercise inhibited activities of FAS, PK, and G6PDH, especially in fructose-fed rats. Study 3 investigated whether chronic exercise training would prevent dietary-induction of FAS and PK. Activities of all enzymes were two times greater in fructose-fed versus cornstarch-fed rats. Cornstarch-fed rats showed significantly lower FAS activity with training; fructose-fed rats had significantly lower PK activity after training.","abstract_html":"Effects of acute exercise and chronic exercise training on activities of five hepatic lipogenic enzymes were studied in rats fed different high-carbohydrate diets. In Study 1, ATP citrate lyase (CL), pyruvate kinase (PK), and fatty acid synthase (FAS) activities were greater in rats fed a high-fructose diet than in rats fed high-glucose or high-cornstarch diets. Exercise decreased CL, PK, FAS, and glucose-6-phosphate dehydrogenase (G6PDH) activities, especially in fructose-fed rats. Study 2 examined the time course of dietary induction of enzymes in fasted/refed rats, and the inhibitory effect of exhaustive exercise on induction. Fasting suppressed all activities to minimal levels. FAS and PK activities increased between 4 and 8 hours of refeeding, then plateaued and were greater in fructose versus cornstarch rats. Activities of malic enzyme, CL, and G6PDH peaked after 48 hours; fructose-fed rats had higher activities than cornstarch-fed rats. Exercise inhibited activities of FAS, PK, and G6PDH, especially in fructose-fed rats. Study 3 investigated whether chronic exercise training would prevent dietary-induction of FAS and PK. Activities of all enzymes were two times greater in fructose-fed versus cornstarch-fed rats. Cornstarch-fed rats showed significantly lower FAS activity with training; fructose-fed rats had significantly lower PK activity after training.","abstract_has_math":false,"creators":["Griffiths, Margaret A."],"institution":"University of Illinois at Urbana-Champaign","degree_name":"Ph.D.","degree_level":"Dissertation","degree_discipline":"Kinesiology","degree_department":null,"school":null,"contributors":["Boileau, Richard A."],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2011,"date_issued":"2011-05-07T13:09:43Z","date_published":"2011-05-07T13:09:43Z","updated_at":"2026-07-22T22:25:18Z","subjects":["Health Sciences, Nutrition"],"languages":["eng"],"rights":["Copyright 1994 Griffiths, Margaret A."],"rights_urls":[],"identifier_entries":[{"key":"dc:identifier","label":"Identifier","values":["AAI9512376","(UMI)AAI9512376"],"render_values":[{"text":"AAI9512376","href":null,"code":true},{"text":"(UMI)AAI9512376","href":null,"code":true}]}]},"links":{"outbound_url":"http://hdl.handle.net/2142/21476","outbound_label":"Handle","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["Boileau, Richard A."]},{"key":"dc:creator","label":"Author","values":["Griffiths, Margaret A."]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["2011-05-07T13:09:43Z","10000-01-01","1994"]},{"key":"dc:type","label":"Dc Type","values":["text"]},{"key":"thesis:degree_discipline","label":"Discipline","values":["Kinesiology"]},{"key":"thesis:degree_level","label":"Degree Level","values":["Dissertation"]},{"key":"thesis:degree_name","label":"Degree Name","values":["Ph.D."]},{"key":"thesis:institution_name","label":"Thesis Institution Name","values":["University of Illinois at Urbana-Champaign"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Health Sciences, Nutrition"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["eng"]},{"key":"dc:rights","label":"Dc Rights","values":["Copyright 1994 Griffiths, Margaret A."]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["AAI9512376","(UMI)AAI9512376","http://hdl.handle.net/2142/21476"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["Effects of acute exercise and chronic exercise training on activities of five hepatic lipogenic enzymes were studied in rats fed different high-carbohydrate diets. In Study 1, ATP citrate lyase (CL), pyruvate kinase (PK), and fatty acid synthase (FAS) activities were greater in rats fed a high-fructose diet than in rats fed high-glucose or high-cornstarch diets. Exercise decreased CL, PK, FAS, and glucose-6-phosphate dehydrogenase (G6PDH) activities, especially in fructose-fed rats. Study 2 examined the time course of dietary induction of enzymes in fasted/refed rats, and the inhibitory effect of exhaustive exercise on induction. Fasting suppressed all activities to minimal levels. FAS and PK activities increased between 4 and 8 hours of refeeding, then plateaued and were greater in fructose versus cornstarch rats. Activities of malic enzyme, CL, and G6PDH peaked after 48 hours; fructose-fed rats had higher activities than cornstarch-fed rats. Exercise inhibited activities of FAS, PK, and G6PDH, especially in fructose-fed rats. Study 3 investigated whether chronic exercise training would prevent dietary-induction of FAS and PK. Activities of all enzymes were two times greater in fructose-fed versus cornstarch-fed rats. Cornstarch-fed rats showed significantly lower FAS activity with training; fructose-fed rats had significantly lower PK activity after training.","Made available in DSpace on 2011-05-07T13:09:43Z (GMT). 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In Study 1, ATP citrate lyase (CL), pyruvate kinase (PK), and fatty acid synthase (FAS) activities were greater in rats fed a high-fructose diet than in rats fed high-glucose or high-cornstarch diets. Exercise decreased CL, PK, FAS, and glucose-6-phosphate dehydrogenase (G6PDH) activities, especially in fructose-fed rats. Study 2 examined the time course of dietary induction of enzymes in fasted/refed rats, and the inhibitory effect of exhaustive exercise on induction. Fasting suppressed all activities to minimal levels. FAS and PK activities increased between 4 and 8 hours of refeeding, then plateaued and were greater in fructose versus cornstarch rats. Activities of malic enzyme, CL, and G6PDH peaked after 48 hours; fructose-fed rats had higher activities than cornstarch-fed rats. Exercise inhibited activities of FAS, PK, and G6PDH, especially in fructose-fed rats. Study 3 investigated whether chronic exercise training would prevent dietary-induction of FAS and PK. 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