{"id":{"repo_id":"uiuc","oai_identifier":"oai:www.ideals.illinois.edu:2142/21420"},"canonical_url":"https://search.dev.ndltd.org/etd/uiuc/oai:www.ideals.illinois.edu:2142/21420","repository":{"repo_id":"uiuc","name":"University of Illinois - Urbana-Champaign","base_url":"https://www.ideals.illinois.edu/oai-pmh"},"display":{"title":"Investigation of transition structure geometries for the transfer of oxygen from heteroatoms to phosphorus","abstract":"The deoxygenation of a functional group containing an oxygen-heteroatom bond by a trivalent phosphorus compound to give the corresponding deoxygenated substrate and oxidized phosphorus compound is a reaction of synthetic and mechanistic importance. The endocyclic restriction test was utilized in this research to investigate transition structure geometries in the transfer of oxygen from heteroatoms to trivalent phosphorus.","abstract_html":"The deoxygenation of a functional group containing an oxygen-heteroatom bond by a trivalent phosphorus compound to give the corresponding deoxygenated substrate and oxidized phosphorus compound is a reaction of synthetic and mechanistic importance. The endocyclic restriction test was utilized in this research to investigate transition structure geometries in the transfer of oxygen from heteroatoms to trivalent phosphorus.","abstract_has_math":false,"creators":["Kurtzweil, Mitchell Lloyd"],"institution":"University of Illinois at Urbana-Champaign","degree_name":"Ph.D.","degree_level":"Dissertation","degree_discipline":"Chemistry","degree_department":null,"school":null,"contributors":["Beak, Peter"],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2011,"date_issued":"2011-05-07T13:08:08Z","date_published":"2011-05-07T13:08:08Z","updated_at":"2026-07-22T22:25:17Z","subjects":["Chemistry, Organic"],"languages":["eng"],"rights":["Copyright 1992 Kurtzweil, Mitchell Lloyd"],"rights_urls":[],"identifier_entries":[{"key":"dc:identifier","label":"Identifier","values":["AAI9305591","(UMI)AAI9305591"],"render_values":[{"text":"AAI9305591","href":null,"code":true},{"text":"(UMI)AAI9305591","href":null,"code":true}]}]},"links":{"outbound_url":"http://hdl.handle.net/2142/21420","outbound_label":"Handle","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["Beak, Peter"]},{"key":"dc:creator","label":"Author","values":["Kurtzweil, Mitchell Lloyd"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["2011-05-07T13:08:08Z","10000-01-01","1992"]},{"key":"dc:type","label":"Dc Type","values":["text"]},{"key":"thesis:degree_discipline","label":"Discipline","values":["Chemistry"]},{"key":"thesis:degree_level","label":"Degree Level","values":["Dissertation"]},{"key":"thesis:degree_name","label":"Degree Name","values":["Ph.D."]},{"key":"thesis:institution_name","label":"Thesis Institution Name","values":["University of Illinois at Urbana-Champaign"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Chemistry, Organic"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["eng"]},{"key":"dc:rights","label":"Dc Rights","values":["Copyright 1992 Kurtzweil, Mitchell Lloyd"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["AAI9305591","(UMI)AAI9305591","http://hdl.handle.net/2142/21420"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["The deoxygenation of a functional group containing an oxygen-heteroatom bond by a trivalent phosphorus compound to give the corresponding deoxygenated substrate and oxidized phosphorus compound is a reaction of synthetic and mechanistic importance. The endocyclic restriction test was utilized in this research to investigate transition structure geometries in the transfer of oxygen from heteroatoms to trivalent phosphorus.","Several systems were investigated which contained a diphenylphosphino group tethered to the oxygen-heteroatom functionality through some number of intervening carbon atoms. The functionalities included a nitrone, a short and long chain hydroxylamine, an O-acetylhydroxylamine, and a sulfoxide. In each system, distinction between intramolecular and intermolecular oxygen transfer was made through double labeling experiments. This information, along with kinetics, $\\sp{18}$O-labeling, and other techniques provided data to distinguish between alternative mechanisms of oxygen transfer.","The conversion of nitrone 95 to imine-phosphine oxide 96 is suggested to occur via an addition-elimination mechanism involving the 6-membered ring intermediate 109.","The conversion of hydroxylamine 24 to amine-phosphine oxide 26 is also considered to occur via an addition-elimination mechanism and involve a 6-membered ring intermediate 196. However, when the HCl salt of 24 is used or when 24 is treated in AcOH, competing processes occur and mechanistic alternatives are not readily distinguishable. By lengthening the hydroxylamine side chain in 153, conversion to amine-phosphine oxide 154 becomes at least partially intermolecular, indicating that intramolecular oxygen transfer is inhibited.","Treatment of O-acetylhydroxylamine 134 in AcOH gives a detectable intermediate 133 which is converted to 26 upon workup. Intermediate 133 is also observed in toluene, but further reaction gives acetamide-phosphine oxide 161.","The conversion of sulfoxide 174 to sulfide-phosphine oxide 175 apparently requires an electrophilic catalyst. Mechanisms involving both 5- and 6-membered ring intermediates, 191 and 197, are proposed depending on the catalyst.","We have found that oxygen transfer to trivalent phosphorus from functionalities containing a heteroatom-oxygen bond can occur through either 5- or 6-membered ring transition state structures involving valence expansion at phosphorus. These reactions are substrate and condition dependent, however.","Made available in DSpace on 2011-05-07T13:08:08Z (GMT). No. of bitstreams: 2 license.txt: 4922 bytes, checksum: 910b249b4beec47e7ab768910c8f966f (MD5) 9305591.pdf: 11365170 bytes, checksum: 6f56d028a95b93b1fa24db241b2d20f1 (MD5) Previous issue date: 1992","Item marked as restricted to the 'UIUC Users [automated]' Group (id=2) by Howard Ding (hding2@illinois.edu) on 2011-05-07T14:50:39Z Item is restricted indefinitely.","Restriction data tranferred 2014-07-01T11:23:10-05:00 Original Data Group with Access UIUC Users [automated] Release Date: none Reason: ETDs are only available to UIUC Users without author permission","ETDs are only available to UIUC Users without author permission","U of I Only"]},{"key":"dc:title","label":"Title","values":["Investigation of transition structure geometries for the transfer of oxygen from heteroatoms to phosphorus"]}]}],"canonical_facts":{"dc:contributor":["Beak, Peter"],"dc:creator":["Kurtzweil, Mitchell Lloyd"],"dc:date":["2011-05-07T13:08:08Z","10000-01-01","1992"],"dc:description":["The deoxygenation of a functional group containing an oxygen-heteroatom bond by a trivalent phosphorus compound to give the corresponding deoxygenated substrate and oxidized phosphorus compound is a reaction of synthetic and mechanistic importance. The endocyclic restriction test was utilized in this research to investigate transition structure geometries in the transfer of oxygen from heteroatoms to trivalent phosphorus.","Several systems were investigated which contained a diphenylphosphino group tethered to the oxygen-heteroatom functionality through some number of intervening carbon atoms. The functionalities included a nitrone, a short and long chain hydroxylamine, an O-acetylhydroxylamine, and a sulfoxide. In each system, distinction between intramolecular and intermolecular oxygen transfer was made through double labeling experiments. This information, along with kinetics, $\\sp{18}$O-labeling, and other techniques provided data to distinguish between alternative mechanisms of oxygen transfer.","The conversion of nitrone 95 to imine-phosphine oxide 96 is suggested to occur via an addition-elimination mechanism involving the 6-membered ring intermediate 109.","The conversion of hydroxylamine 24 to amine-phosphine oxide 26 is also considered to occur via an addition-elimination mechanism and involve a 6-membered ring intermediate 196. However, when the HCl salt of 24 is used or when 24 is treated in AcOH, competing processes occur and mechanistic alternatives are not readily distinguishable. By lengthening the hydroxylamine side chain in 153, conversion to amine-phosphine oxide 154 becomes at least partially intermolecular, indicating that intramolecular oxygen transfer is inhibited.","Treatment of O-acetylhydroxylamine 134 in AcOH gives a detectable intermediate 133 which is converted to 26 upon workup. Intermediate 133 is also observed in toluene, but further reaction gives acetamide-phosphine oxide 161.","The conversion of sulfoxide 174 to sulfide-phosphine oxide 175 apparently requires an electrophilic catalyst. Mechanisms involving both 5- and 6-membered ring intermediates, 191 and 197, are proposed depending on the catalyst.","We have found that oxygen transfer to trivalent phosphorus from functionalities containing a heteroatom-oxygen bond can occur through either 5- or 6-membered ring transition state structures involving valence expansion at phosphorus. These reactions are substrate and condition dependent, however.","Made available in DSpace on 2011-05-07T13:08:08Z (GMT). No. of bitstreams: 2 license.txt: 4922 bytes, checksum: 910b249b4beec47e7ab768910c8f966f (MD5) 9305591.pdf: 11365170 bytes, checksum: 6f56d028a95b93b1fa24db241b2d20f1 (MD5) Previous issue date: 1992","Item marked as restricted to the 'UIUC Users [automated]' Group (id=2) by Howard Ding (hding2@illinois.edu) on 2011-05-07T14:50:39Z Item is restricted indefinitely.","Restriction data tranferred 2014-07-01T11:23:10-05:00 Original Data Group with Access UIUC Users [automated] Release Date: none Reason: ETDs are only available to UIUC Users without author permission","ETDs are only available to UIUC Users without author permission","U of I Only"],"dc:identifier":["AAI9305591","(UMI)AAI9305591","http://hdl.handle.net/2142/21420"],"dc:language":["eng"],"dc:rights":["Copyright 1992 Kurtzweil, Mitchell Lloyd"],"dc:subject":["Chemistry, Organic"],"dc:title":["Investigation of transition structure geometries for the transfer of oxygen from heteroatoms to phosphorus"],"dc:type":["text"],"thesis:degree_discipline":["Chemistry"],"thesis:degree_level":["Dissertation"],"thesis:degree_name":["Ph.D."],"thesis:institution_name":["University of Illinois at Urbana-Champaign"]},"updated_at":"2026-07-22T22:25:17Z"}