{"id":{"repo_id":"uiuc","oai_identifier":"oai:www.ideals.illinois.edu:2142/21330"},"canonical_url":"https://search.dev.ndltd.org/etd/uiuc/oai:www.ideals.illinois.edu:2142/21330","repository":{"repo_id":"uiuc","name":"University of Illinois - Urbana-Champaign","base_url":"https://www.ideals.illinois.edu/oai-pmh"},"display":{"title":"An evaluation of a proposed animal model of depression: Effect on adult behavior and response to imipramine in three tests","abstract":"Antidepressant (AD) administration to developing rats produces behavioral alterations in adulthood. The similarity between these behavioral alterations and symptoms of depressive disorder suggested that juvenile antidepressant administration may be useful as an animal model of depression.","abstract_html":"Antidepressant (AD) administration to developing rats produces behavioral alterations in adulthood. The similarity between these behavioral alterations and symptoms of depressive disorder suggested that juvenile antidepressant administration may be useful as an animal model of depression.","abstract_has_math":false,"creators":["Dwyer, Kathleen Dale"],"institution":"University of Illinois at Urbana-Champaign","degree_name":"Ph.D.","degree_level":"Dissertation","degree_discipline":"Neuroscience","degree_department":null,"school":null,"contributors":["Roy, Edward J."],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2011,"date_issued":"2011-05-07T13:05:31Z","date_published":"2011-05-07T13:05:31Z","updated_at":"2026-07-22T22:25:17Z","subjects":["Biology, Neuroscience","Psychology, Behavioral"],"languages":["eng"],"rights":["Copyright 1992 Dwyer, Kathleen Dale"],"rights_urls":[],"identifier_entries":[{"key":"dc:identifier","label":"Identifier","values":["AAI9236443","(UMI)AAI9236443"],"render_values":[{"text":"AAI9236443","href":null,"code":true},{"text":"(UMI)AAI9236443","href":null,"code":true}]}]},"links":{"outbound_url":"http://hdl.handle.net/2142/21330","outbound_label":"Handle","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["Roy, Edward J."]},{"key":"dc:creator","label":"Author","values":["Dwyer, Kathleen Dale"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["2011-05-07T13:05:31Z","10000-01-01","1992"]},{"key":"dc:type","label":"Dc Type","values":["text"]},{"key":"thesis:degree_discipline","label":"Discipline","values":["Neuroscience"]},{"key":"thesis:degree_level","label":"Degree Level","values":["Dissertation"]},{"key":"thesis:degree_name","label":"Degree Name","values":["Ph.D."]},{"key":"thesis:institution_name","label":"Thesis Institution Name","values":["University of Illinois at Urbana-Champaign"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Biology, Neuroscience","Psychology, Behavioral"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["eng"]},{"key":"dc:rights","label":"Dc Rights","values":["Copyright 1992 Dwyer, Kathleen Dale"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["AAI9236443","(UMI)AAI9236443","http://hdl.handle.net/2142/21330"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["Antidepressant (AD) administration to developing rats produces behavioral alterations in adulthood. The similarity between these behavioral alterations and symptoms of depressive disorder suggested that juvenile antidepressant administration may be useful as an animal model of depression.","In these studies, adult female rats administered the AD desipramine as juveniles (Jdes animals) behaved different in initial exposures to the Porsolt forced swimming test compared with animals that were not handled as juveniles (Junh controls), but similar compared with juvenile saline treated (Jsal) controls. Imipramine influenced swim behavior in all groups when administered short-term after a pretest exposure to the swim test, or when administered long-term. Imipramine did not influence behavior in Jdes animals, but did influence behavior in Junh and Jsal controls, when administered short-term with no pretest exposure to the swim test.","Open field behavior of all juvenile treatment groups was influenced by short-term imipramine. Long-term imipramine did not influence the open field behavior of Jdes animals, but did influence behavior of Jsal and Junh controls.","Baseline diurnal running wheel activity showed only minor alterations due to juvenile treatment. With imipramine administration diurnal running wheel activity is phase delayed. Jdes animals were more sensitive to the phase-delaying effects of imipramine compared with Jsal controls, and less sensitive to the phase-delaying effects of imipramine compared with Junh controls.","The reduced sensitivity to imipramine observed in Jdes animals, under certain conditions, indicates that Jdes treatment does not produce a useful animal model of depression for studying AD action. These results underscore the possibility that ADs administered to pregnant and nursing women may have permanent effects on their progeny.","The effect of imipramine administration on forced swimming test behavior and open field behavior was also different for Junh controls and Jsal controls, under certain conditions. It is suggested that the early handling received by Jsal controls, but not by Junh controls, may explain these different behavioral responses to imipramine.","Made available in DSpace on 2011-05-07T13:05:31Z (GMT). No. of bitstreams: 2 license.txt: 4922 bytes, checksum: 910b249b4beec47e7ab768910c8f966f (MD5) 9236443.pdf: 4161443 bytes, checksum: 12641e13b988cd693bbed31ccd560009 (MD5) Previous issue date: 1992","Item marked as restricted to the 'UIUC Users [automated]' Group (id=2) by Howard Ding (hding2@illinois.edu) on 2011-05-07T14:50:02Z Item is restricted indefinitely.","Restriction data tranferred 2014-07-01T11:22:49-05:00 Original Data Group with Access UIUC Users [automated] Release Date: none Reason: ETDs are only available to UIUC Users without author permission","ETDs are only available to UIUC Users without author permission","U of I Only"]},{"key":"dc:title","label":"Title","values":["An evaluation of a proposed animal model of depression: Effect on adult behavior and response to imipramine in three tests"]}]}],"canonical_facts":{"dc:contributor":["Roy, Edward J."],"dc:creator":["Dwyer, Kathleen Dale"],"dc:date":["2011-05-07T13:05:31Z","10000-01-01","1992"],"dc:description":["Antidepressant (AD) administration to developing rats produces behavioral alterations in adulthood. The similarity between these behavioral alterations and symptoms of depressive disorder suggested that juvenile antidepressant administration may be useful as an animal model of depression.","In these studies, adult female rats administered the AD desipramine as juveniles (Jdes animals) behaved different in initial exposures to the Porsolt forced swimming test compared with animals that were not handled as juveniles (Junh controls), but similar compared with juvenile saline treated (Jsal) controls. Imipramine influenced swim behavior in all groups when administered short-term after a pretest exposure to the swim test, or when administered long-term. Imipramine did not influence behavior in Jdes animals, but did influence behavior in Junh and Jsal controls, when administered short-term with no pretest exposure to the swim test.","Open field behavior of all juvenile treatment groups was influenced by short-term imipramine. Long-term imipramine did not influence the open field behavior of Jdes animals, but did influence behavior of Jsal and Junh controls.","Baseline diurnal running wheel activity showed only minor alterations due to juvenile treatment. With imipramine administration diurnal running wheel activity is phase delayed. Jdes animals were more sensitive to the phase-delaying effects of imipramine compared with Jsal controls, and less sensitive to the phase-delaying effects of imipramine compared with Junh controls.","The reduced sensitivity to imipramine observed in Jdes animals, under certain conditions, indicates that Jdes treatment does not produce a useful animal model of depression for studying AD action. These results underscore the possibility that ADs administered to pregnant and nursing women may have permanent effects on their progeny.","The effect of imipramine administration on forced swimming test behavior and open field behavior was also different for Junh controls and Jsal controls, under certain conditions. It is suggested that the early handling received by Jsal controls, but not by Junh controls, may explain these different behavioral responses to imipramine.","Made available in DSpace on 2011-05-07T13:05:31Z (GMT). No. of bitstreams: 2 license.txt: 4922 bytes, checksum: 910b249b4beec47e7ab768910c8f966f (MD5) 9236443.pdf: 4161443 bytes, checksum: 12641e13b988cd693bbed31ccd560009 (MD5) Previous issue date: 1992","Item marked as restricted to the 'UIUC Users [automated]' Group (id=2) by Howard Ding (hding2@illinois.edu) on 2011-05-07T14:50:02Z Item is restricted indefinitely.","Restriction data tranferred 2014-07-01T11:22:49-05:00 Original Data Group with Access UIUC Users [automated] Release Date: none Reason: ETDs are only available to UIUC Users without author permission","ETDs are only available to UIUC Users without author permission","U of I Only"],"dc:identifier":["AAI9236443","(UMI)AAI9236443","http://hdl.handle.net/2142/21330"],"dc:language":["eng"],"dc:rights":["Copyright 1992 Dwyer, Kathleen Dale"],"dc:subject":["Biology, Neuroscience","Psychology, Behavioral"],"dc:title":["An evaluation of a proposed animal model of depression: Effect on adult behavior and response to imipramine in three tests"],"dc:type":["text"],"thesis:degree_discipline":["Neuroscience"],"thesis:degree_level":["Dissertation"],"thesis:degree_name":["Ph.D."],"thesis:institution_name":["University of Illinois at Urbana-Champaign"]},"updated_at":"2026-07-22T22:25:17Z"}