{"id":{"repo_id":"uiuc","oai_identifier":"oai:www.ideals.illinois.edu:2142/21258"},"canonical_url":"https://search.dev.ndltd.org/etd/uiuc/oai:www.ideals.illinois.edu:2142/21258","repository":{"repo_id":"uiuc","name":"University of Illinois - Urbana-Champaign","base_url":"https://www.ideals.illinois.edu/oai-pmh"},"display":{"title":"Hepatic lipid metabolism and peroxisomal beta-oxidation in dairy cows","abstract":"Five experiments were conducted to measure peroxisomal $\\beta$-oxidation in the liver of cows and to determine the effects of physiological state and source of dietary energy (carbohydrate or lipid) on liver metabolism, blood metabolites, and production variables.","abstract_html":"Five experiments were conducted to measure peroxisomal <span class=\"etd-inline-math\">&beta;</span>-oxidation in the liver of cows and to determine the effects of physiological state and source of dietary energy (carbohydrate or lipid) on liver metabolism, blood metabolites, and production variables.","abstract_has_math":true,"creators":["Grum, David Eric"],"institution":"University of Illinois at Urbana-Champaign","degree_name":"Ph.D.","degree_level":"Dissertation","degree_discipline":"Animal Sciences","degree_department":null,"school":null,"contributors":["Drackley, James K."],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2011,"date_issued":"2011-05-07T13:03:15Z","date_published":"2011-05-07T13:03:15Z","updated_at":"2026-07-22T22:25:17Z","subjects":["Biology, Animal Physiology","Agriculture, Animal Culture and Nutrition"],"languages":["eng"],"rights":["Copyright 1994 Grum, David Eric"],"rights_urls":[],"identifier_entries":[{"key":"dc:identifier","label":"Identifier","values":["AAI9512377","(UMI)AAI9512377"],"render_values":[{"text":"AAI9512377","href":null,"code":true},{"text":"(UMI)AAI9512377","href":null,"code":true}]}]},"links":{"outbound_url":"http://hdl.handle.net/2142/21258","outbound_label":"Handle","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["Drackley, James K."]},{"key":"dc:creator","label":"Author","values":["Grum, David Eric"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["2011-05-07T13:03:15Z","10000-01-01","1994"]},{"key":"dc:type","label":"Dc Type","values":["text"]},{"key":"thesis:degree_discipline","label":"Discipline","values":["Animal Sciences"]},{"key":"thesis:degree_level","label":"Degree Level","values":["Dissertation"]},{"key":"thesis:degree_name","label":"Degree Name","values":["Ph.D."]},{"key":"thesis:institution_name","label":"Thesis Institution Name","values":["University of Illinois at Urbana-Champaign"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Biology, Animal Physiology","Agriculture, Animal Culture and Nutrition"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["eng"]},{"key":"dc:rights","label":"Dc Rights","values":["Copyright 1994 Grum, David Eric"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["AAI9512377","(UMI)AAI9512377","http://hdl.handle.net/2142/21258"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["Five experiments were conducted to measure peroxisomal $\\beta$-oxidation in the liver of cows and to determine the effects of physiological state and source of dietary energy (carbohydrate or lipid) on liver metabolism, blood metabolites, and production variables.","The in vitro capacity for peroxisomal $\\beta$-oxidation of palmitate in liver homogenates represented approximately 50% of the total $\\beta$-oxidative capacity in cows but only 30% in rats. Fasting increased peroxisomal $\\beta$-oxidation in rats but not cows. The rate of peroxisomal $\\beta$-oxidation was not altered by diet during midlactation, but increased in late lactation. Feeding supplemental fat throughout the dry period increased the rate of peroxisomal $\\beta$-oxidation. Dietary fat can increase the rate of peroxisomal $\\beta$-oxidation, but this appears to be limited to the periparturient period.","When supplemental dietary energy was fed as carbohydrate or lipid, the rate of palmitate esterification in liver slices from cows in midlactation was not altered, but esterification decreased when fat was fed throughout the dry period. Feeding supplemental fat throughout the dry period decreased hepatic concentrations of total lipid and triglyceride after parturition; the decrease was related to increased peroxisomal $\\beta$-oxidation, decreased esterification, and decreased concentration of NEFA in plasma. Source of dietary energy did not alter the accumulation of total lipid or triglyceride in the liver of cows in mid-or late lactation. Hepatic glycogen content was increased by feeding additional concentrate throughout the dry period or during midlactation. Nicotinic acid increased hepatic concentration of total lipid when it was added to a control diet but decreased hepatic lipid when added to a fat-supplemented diet during early lactation.","Milk production was not altered by source of dietary energy but was increased by nicotinic acid. Yield and percentage of milk fat decreased when cows in midlactation were fed diets supplemented with additional concentrate, but increased when diets were supplemented with fat. Feeding supplemental fat during the dry period decreased milk fat percentage and yield during early lactation, but did not affect milk production. Yields and percentages of milk CP and N fractions generally were not changed by source of dietary energy. Feeding additional concentrate decreased the digestibility of fatty acids of cows in midlactation.","Made available in DSpace on 2011-05-07T13:03:15Z (GMT). No. of bitstreams: 2 license.txt: 4922 bytes, checksum: 910b249b4beec47e7ab768910c8f966f (MD5) 9512377.pdf: 8407121 bytes, checksum: d8310f39d3ad085f6330f69520401952 (MD5) Previous issue date: 1994","Item marked as restricted to the 'UIUC Users [automated]' Group (id=2) by Howard Ding (hding2@illinois.edu) on 2011-05-07T14:49:33Z Item is restricted indefinitely.","Restriction data tranferred 2014-07-01T11:22:33-05:00 Original Data Group with Access UIUC Users [automated] Release Date: none Reason: ETDs are only available to UIUC Users without author permission","ETDs are only available to UIUC Users without author permission","U of I Only"]},{"key":"dc:title","label":"Title","values":["Hepatic lipid metabolism and peroxisomal beta-oxidation in dairy cows"]}]}],"canonical_facts":{"dc:contributor":["Drackley, James K."],"dc:creator":["Grum, David Eric"],"dc:date":["2011-05-07T13:03:15Z","10000-01-01","1994"],"dc:description":["Five experiments were conducted to measure peroxisomal $\\beta$-oxidation in the liver of cows and to determine the effects of physiological state and source of dietary energy (carbohydrate or lipid) on liver metabolism, blood metabolites, and production variables.","The in vitro capacity for peroxisomal $\\beta$-oxidation of palmitate in liver homogenates represented approximately 50% of the total $\\beta$-oxidative capacity in cows but only 30% in rats. Fasting increased peroxisomal $\\beta$-oxidation in rats but not cows. The rate of peroxisomal $\\beta$-oxidation was not altered by diet during midlactation, but increased in late lactation. Feeding supplemental fat throughout the dry period increased the rate of peroxisomal $\\beta$-oxidation. Dietary fat can increase the rate of peroxisomal $\\beta$-oxidation, but this appears to be limited to the periparturient period.","When supplemental dietary energy was fed as carbohydrate or lipid, the rate of palmitate esterification in liver slices from cows in midlactation was not altered, but esterification decreased when fat was fed throughout the dry period. Feeding supplemental fat throughout the dry period decreased hepatic concentrations of total lipid and triglyceride after parturition; the decrease was related to increased peroxisomal $\\beta$-oxidation, decreased esterification, and decreased concentration of NEFA in plasma. Source of dietary energy did not alter the accumulation of total lipid or triglyceride in the liver of cows in mid-or late lactation. Hepatic glycogen content was increased by feeding additional concentrate throughout the dry period or during midlactation. Nicotinic acid increased hepatic concentration of total lipid when it was added to a control diet but decreased hepatic lipid when added to a fat-supplemented diet during early lactation.","Milk production was not altered by source of dietary energy but was increased by nicotinic acid. Yield and percentage of milk fat decreased when cows in midlactation were fed diets supplemented with additional concentrate, but increased when diets were supplemented with fat. Feeding supplemental fat during the dry period decreased milk fat percentage and yield during early lactation, but did not affect milk production. Yields and percentages of milk CP and N fractions generally were not changed by source of dietary energy. Feeding additional concentrate decreased the digestibility of fatty acids of cows in midlactation.","Made available in DSpace on 2011-05-07T13:03:15Z (GMT). No. of bitstreams: 2 license.txt: 4922 bytes, checksum: 910b249b4beec47e7ab768910c8f966f (MD5) 9512377.pdf: 8407121 bytes, checksum: d8310f39d3ad085f6330f69520401952 (MD5) Previous issue date: 1994","Item marked as restricted to the 'UIUC Users [automated]' Group (id=2) by Howard Ding (hding2@illinois.edu) on 2011-05-07T14:49:33Z Item is restricted indefinitely.","Restriction data tranferred 2014-07-01T11:22:33-05:00 Original Data Group with Access UIUC Users [automated] Release Date: none Reason: ETDs are only available to UIUC Users without author permission","ETDs are only available to UIUC Users without author permission","U of I Only"],"dc:identifier":["AAI9512377","(UMI)AAI9512377","http://hdl.handle.net/2142/21258"],"dc:language":["eng"],"dc:rights":["Copyright 1994 Grum, David Eric"],"dc:subject":["Biology, Animal Physiology","Agriculture, Animal Culture and Nutrition"],"dc:title":["Hepatic lipid metabolism and peroxisomal beta-oxidation in dairy cows"],"dc:type":["text"],"thesis:degree_discipline":["Animal Sciences"],"thesis:degree_level":["Dissertation"],"thesis:degree_name":["Ph.D."],"thesis:institution_name":["University of Illinois at Urbana-Champaign"]},"updated_at":"2026-07-22T22:25:17Z"}