{"id":{"repo_id":"uiuc","oai_identifier":"oai:www.ideals.illinois.edu:2142/21218"},"canonical_url":"https://search.dev.ndltd.org/etd/uiuc/oai:www.ideals.illinois.edu:2142/21218","repository":{"repo_id":"uiuc","name":"University of Illinois - Urbana-Champaign","base_url":"https://www.ideals.illinois.edu/oai-pmh"},"display":{"title":"The cardiovascular effects of the pharmacological interruption of the brain renin-angiotensin system in Dahl salt-induced hypertension","abstract":"Made available in DSpace on 2011-05-07T13:01:59Z (GMT). No. of bitstreams: 2 license.txt: 4922 bytes, checksum: 910b249b4beec47e7ab768910c8f966f (MD5) 9416390.pdf: 5287338 bytes, checksum: 7ad9cc893a5c5e88bc49745c02568e9f (MD5) Previous issue date: 1994","abstract_html":"Made available in DSpace on 2011-05-07T13:01:59Z (GMT). No. of bitstreams: 2 license.txt: 4922 bytes, checksum: 910b249b4beec47e7ab768910c8f966f (MD5) 9416390.pdf: 5287338 bytes, checksum: 7ad9cc893a5c5e88bc49745c02568e9f (MD5) Previous issue date: 1994","abstract_has_math":false,"creators":["Lark, Lisa Anne"],"institution":"University of Illinois at Urbana-Champaign","degree_name":"Ph.D.","degree_level":"Dissertation","degree_discipline":"Neuroscience","degree_department":null,"school":null,"contributors":["Weyhenmeyer, James A."],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2011,"date_issued":"2011-05-07T13:01:59Z","date_published":"2011-05-07T13:01:59Z","updated_at":"2026-07-22T22:25:17Z","subjects":["Biology, Neuroscience"],"languages":["eng"],"rights":["Copyright 1994 Lark, Lisa Anne"],"rights_urls":[],"identifier_entries":[{"key":"dc:identifier","label":"Identifier","values":["AAI9416390","(UMI)AAI9416390"],"render_values":[{"text":"AAI9416390","href":null,"code":true},{"text":"(UMI)AAI9416390","href":null,"code":true}]}]},"links":{"outbound_url":"http://hdl.handle.net/2142/21218","outbound_label":"Handle","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["Weyhenmeyer, James A."]},{"key":"dc:creator","label":"Author","values":["Lark, Lisa Anne"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["2011-05-07T13:01:59Z","10000-01-01","1994"]},{"key":"dc:type","label":"Dc Type","values":["text"]},{"key":"thesis:degree_discipline","label":"Discipline","values":["Neuroscience"]},{"key":"thesis:degree_level","label":"Degree Level","values":["Dissertation"]},{"key":"thesis:degree_name","label":"Degree Name","values":["Ph.D."]},{"key":"thesis:institution_name","label":"Thesis Institution Name","values":["University of Illinois at Urbana-Champaign"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Biology, Neuroscience"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["eng"]},{"key":"dc:rights","label":"Dc Rights","values":["Copyright 1994 Lark, Lisa Anne"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["AAI9416390","(UMI)AAI9416390","http://hdl.handle.net/2142/21218"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["Made available in DSpace on 2011-05-07T13:01:59Z (GMT). No. of bitstreams: 2 license.txt: 4922 bytes, checksum: 910b249b4beec47e7ab768910c8f966f (MD5) 9416390.pdf: 5287338 bytes, checksum: 7ad9cc893a5c5e88bc49745c02568e9f (MD5) Previous issue date: 1994","Item marked as restricted to the 'UIUC Users [automated]' Group (id=2) by Howard Ding (hding2@illinois.edu) on 2011-05-07T14:49:17Z Item is restricted indefinitely.","The brain renin-angiotensin system (RAS) is a known regulator of cardiovascular function. The present studies investigated the cardiovascular effects of the pharmacological interruption of this system in hypertensive inbred Dahl salt-sensitive (DS/JR) rats.","Intracerebroventricular (i.c.v.) administration of the angiotensin converting enzyme inhibitor captopril (10 $\\mu$g) to conscious, freely moving DS/JR rats produced a sustained depressor response but was without effect in normotensive control inbred Dahl salt-resistant rats.","Remaining studies focused on the effects of centrally administered peptide and nonpeptide angiotensin II (ANG II) antagonists in DS/JR rats. Both the peptide antagonist sarthran (20 $\\mu$g) and the nonpeptide antagonist losartan (10 $\\mu$g), which is specific to the AT$\\sb1$ receptor subtype, blocked pressor and dipsogenic responses to i.c.v. ANG II. The AT$\\sb2$ receptor antagonist PD 123319 (10 $\\mu$g) did not block the responses. Sarthran alone produced a significant and short-lived bradycardia with an accompanying slight depressor response. Losartan and PD 123319 were without effect on blood pressure and heart rate.","The sarthran-induced bradycardia was further evaluated by examining its magnitude after preblockade of one or both of the ANG II receptor subtypes. Both losartan and PD 123319 (10 $\\mu$g) inhibited the bradycardic response to 20 $\\mu$g of sarthran by about 45%. Preblockade of both sites resulted in a slightly greater inhibition suggesting that sarthran's effects are mediated interdependently by the AT$\\sb1$ and AT$\\sb2$ sites.","In summary, the present studies demonstrated that the brain RAS is involved in cardiovascular regulation in the DS/JR rat and, as such, may be a potential target for the treatment of salt-induced hypertension. Furthermore, evidence was presented which suggests that both ANG II receptor subtypes are involved in this function.","Restriction data tranferred 2014-07-01T11:22:24-05:00 Original Data Group with Access UIUC Users [automated] Release Date: none Reason: ETDs are only available to UIUC Users without author permission","ETDs are only available to UIUC Users without author permission","U of I Only"]},{"key":"dc:title","label":"Title","values":["The cardiovascular effects of the pharmacological interruption of the brain renin-angiotensin system in Dahl salt-induced hypertension"]}]}],"canonical_facts":{"dc:contributor":["Weyhenmeyer, James A."],"dc:creator":["Lark, Lisa Anne"],"dc:date":["2011-05-07T13:01:59Z","10000-01-01","1994"],"dc:description":["Made available in DSpace on 2011-05-07T13:01:59Z (GMT). No. of bitstreams: 2 license.txt: 4922 bytes, checksum: 910b249b4beec47e7ab768910c8f966f (MD5) 9416390.pdf: 5287338 bytes, checksum: 7ad9cc893a5c5e88bc49745c02568e9f (MD5) Previous issue date: 1994","Item marked as restricted to the 'UIUC Users [automated]' Group (id=2) by Howard Ding (hding2@illinois.edu) on 2011-05-07T14:49:17Z Item is restricted indefinitely.","The brain renin-angiotensin system (RAS) is a known regulator of cardiovascular function. The present studies investigated the cardiovascular effects of the pharmacological interruption of this system in hypertensive inbred Dahl salt-sensitive (DS/JR) rats.","Intracerebroventricular (i.c.v.) administration of the angiotensin converting enzyme inhibitor captopril (10 $\\mu$g) to conscious, freely moving DS/JR rats produced a sustained depressor response but was without effect in normotensive control inbred Dahl salt-resistant rats.","Remaining studies focused on the effects of centrally administered peptide and nonpeptide angiotensin II (ANG II) antagonists in DS/JR rats. Both the peptide antagonist sarthran (20 $\\mu$g) and the nonpeptide antagonist losartan (10 $\\mu$g), which is specific to the AT$\\sb1$ receptor subtype, blocked pressor and dipsogenic responses to i.c.v. ANG II. The AT$\\sb2$ receptor antagonist PD 123319 (10 $\\mu$g) did not block the responses. Sarthran alone produced a significant and short-lived bradycardia with an accompanying slight depressor response. Losartan and PD 123319 were without effect on blood pressure and heart rate.","The sarthran-induced bradycardia was further evaluated by examining its magnitude after preblockade of one or both of the ANG II receptor subtypes. Both losartan and PD 123319 (10 $\\mu$g) inhibited the bradycardic response to 20 $\\mu$g of sarthran by about 45%. Preblockade of both sites resulted in a slightly greater inhibition suggesting that sarthran's effects are mediated interdependently by the AT$\\sb1$ and AT$\\sb2$ sites.","In summary, the present studies demonstrated that the brain RAS is involved in cardiovascular regulation in the DS/JR rat and, as such, may be a potential target for the treatment of salt-induced hypertension. Furthermore, evidence was presented which suggests that both ANG II receptor subtypes are involved in this function.","Restriction data tranferred 2014-07-01T11:22:24-05:00 Original Data Group with Access UIUC Users [automated] Release Date: none Reason: ETDs are only available to UIUC Users without author permission","ETDs are only available to UIUC Users without author permission","U of I Only"],"dc:identifier":["AAI9416390","(UMI)AAI9416390","http://hdl.handle.net/2142/21218"],"dc:language":["eng"],"dc:rights":["Copyright 1994 Lark, Lisa Anne"],"dc:subject":["Biology, Neuroscience"],"dc:title":["The cardiovascular effects of the pharmacological interruption of the brain renin-angiotensin system in Dahl salt-induced hypertension"],"dc:type":["text"],"thesis:degree_discipline":["Neuroscience"],"thesis:degree_level":["Dissertation"],"thesis:degree_name":["Ph.D."],"thesis:institution_name":["University of Illinois at Urbana-Champaign"]},"updated_at":"2026-07-22T22:25:17Z"}