{"id":{"repo_id":"uiuc","oai_identifier":"oai:www.ideals.illinois.edu:2142/21144"},"canonical_url":"https://search.dev.ndltd.org/etd/uiuc/oai:www.ideals.illinois.edu:2142/21144","repository":{"repo_id":"uiuc","name":"University of Illinois - Urbana-Champaign","base_url":"https://www.ideals.illinois.edu/oai-pmh"},"display":{"title":"Developmental influences of thyroid hormones on the rat olfactory receptor sheet","abstract":"Although much is known about the regulatory role of thyroid hormones on brain development, little is known about the effects of thyroid hormones on the development of the peripheral nervous system. The major aim of this thesis therefore, is to examine the role of thyroid hormones on the postnatal development of the olfactory receptor sheet (epithelium) of the rat. Quantitative, light microscopic morphometric and cell count studies were carried out on the olfactory epithelium of growing normal, hypothyroid, hypothyroid/recovery and hyperthyroid rats to measure olfactory neuronal proliferation and maturation.","abstract_html":"Although much is known about the regulatory role of thyroid hormones on brain development, little is known about the effects of thyroid hormones on the development of the peripheral nervous system. The major aim of this thesis therefore, is to examine the role of thyroid hormones on the postnatal development of the olfactory receptor sheet (epithelium) of the rat. Quantitative, light microscopic morphometric and cell count studies were carried out on the olfactory epithelium of growing normal, hypothyroid, hypothyroid/recovery and hyperthyroid rats to measure olfactory neuronal proliferation and maturation.","abstract_has_math":false,"creators":["Paternostro, Mark Anthony"],"institution":"University of Illinois at Urbana-Champaign","degree_name":"Ph.D.","degree_level":"Dissertation","degree_discipline":"Physiology","degree_department":null,"school":null,"contributors":["Meismai, Esmail"],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2011,"date_issued":"2011-05-07T12:59:40Z","date_published":"2011-05-07T12:59:40Z","updated_at":"2026-07-22T22:25:17Z","subjects":["Biology, Neuroscience","Biology, Animal Physiology"],"languages":["eng"],"rights":["Copyright 1992 Paternostro, Mark Anthony"],"rights_urls":[],"identifier_entries":[{"key":"dc:identifier","label":"Identifier","values":["AAI9236564","(UMI)AAI9236564"],"render_values":[{"text":"AAI9236564","href":null,"code":true},{"text":"(UMI)AAI9236564","href":null,"code":true}]}]},"links":{"outbound_url":"http://hdl.handle.net/2142/21144","outbound_label":"Handle","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["Meismai, Esmail"]},{"key":"dc:creator","label":"Author","values":["Paternostro, Mark Anthony"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["2011-05-07T12:59:40Z","10000-01-01","1992"]},{"key":"dc:type","label":"Dc Type","values":["text"]},{"key":"thesis:degree_discipline","label":"Discipline","values":["Physiology"]},{"key":"thesis:degree_level","label":"Degree Level","values":["Dissertation"]},{"key":"thesis:degree_name","label":"Degree Name","values":["Ph.D."]},{"key":"thesis:institution_name","label":"Thesis Institution Name","values":["University of Illinois at Urbana-Champaign"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Biology, Neuroscience","Biology, Animal Physiology"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["eng"]},{"key":"dc:rights","label":"Dc Rights","values":["Copyright 1992 Paternostro, Mark Anthony"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["AAI9236564","(UMI)AAI9236564","http://hdl.handle.net/2142/21144"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["Although much is known about the regulatory role of thyroid hormones on brain development, little is known about the effects of thyroid hormones on the development of the peripheral nervous system. The major aim of this thesis therefore, is to examine the role of thyroid hormones on the postnatal development of the olfactory receptor sheet (epithelium) of the rat. Quantitative, light microscopic morphometric and cell count studies were carried out on the olfactory epithelium of growing normal, hypothyroid, hypothyroid/recovery and hyperthyroid rats to measure olfactory neuronal proliferation and maturation.","Our results have found that hypothyroidism during early postnatal development results in partial suppression of olfactory neuronal proliferation and maturation, while prolonged hypothyroidism resulted in complete suppression of epithelial growth. Thus, hypothyroidism led to significant reductions in the normal accretion of olfactory neurons. Unlike thyroid deficiency, hyperthyroidism was found to have no significant effect on olfactory neuronal proliferation or maturation.","Animals rehabilitated from hypothyroidism at weaning showed a resumption of epithelial growth such that by the age of 90 days, the deficits in neuronal number were completely overcome, while the number of mature neurons showed substantial but incomplete recovery. These results show that unlike central neural structures, the olfactory epithelium of the rat retains the ability to recover from early hypothyroid retardation.","Made available in DSpace on 2011-05-07T12:59:40Z (GMT). No. of bitstreams: 2 license.txt: 4922 bytes, checksum: 910b249b4beec47e7ab768910c8f966f (MD5) 9236564.pdf: 8020665 bytes, checksum: ffb5a97c266f9c593d5d6c4c7db938ae (MD5) Previous issue date: 1992","Item marked as restricted to the 'UIUC Users [automated]' Group (id=2) by Howard Ding (hding2@illinois.edu) on 2011-05-07T14:48:47Z Item is restricted indefinitely.","Restriction data tranferred 2014-07-01T11:22:07-05:00 Original Data Group with Access UIUC Users [automated] Release Date: none Reason: ETDs are only available to UIUC Users without author permission","ETDs are only available to UIUC Users without author permission","U of I Only"]},{"key":"dc:title","label":"Title","values":["Developmental influences of thyroid hormones on the rat olfactory receptor sheet"]}]}],"canonical_facts":{"dc:contributor":["Meismai, Esmail"],"dc:creator":["Paternostro, Mark Anthony"],"dc:date":["2011-05-07T12:59:40Z","10000-01-01","1992"],"dc:description":["Although much is known about the regulatory role of thyroid hormones on brain development, little is known about the effects of thyroid hormones on the development of the peripheral nervous system. The major aim of this thesis therefore, is to examine the role of thyroid hormones on the postnatal development of the olfactory receptor sheet (epithelium) of the rat. Quantitative, light microscopic morphometric and cell count studies were carried out on the olfactory epithelium of growing normal, hypothyroid, hypothyroid/recovery and hyperthyroid rats to measure olfactory neuronal proliferation and maturation.","Our results have found that hypothyroidism during early postnatal development results in partial suppression of olfactory neuronal proliferation and maturation, while prolonged hypothyroidism resulted in complete suppression of epithelial growth. Thus, hypothyroidism led to significant reductions in the normal accretion of olfactory neurons. Unlike thyroid deficiency, hyperthyroidism was found to have no significant effect on olfactory neuronal proliferation or maturation.","Animals rehabilitated from hypothyroidism at weaning showed a resumption of epithelial growth such that by the age of 90 days, the deficits in neuronal number were completely overcome, while the number of mature neurons showed substantial but incomplete recovery. These results show that unlike central neural structures, the olfactory epithelium of the rat retains the ability to recover from early hypothyroid retardation.","Made available in DSpace on 2011-05-07T12:59:40Z (GMT). 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