{"id":{"repo_id":"uiuc","oai_identifier":"oai:www.ideals.illinois.edu:2142/20951"},"canonical_url":"https://search.dev.ndltd.org/etd/uiuc/oai:www.ideals.illinois.edu:2142/20951","repository":{"repo_id":"uiuc","name":"University of Illinois - Urbana-Champaign","base_url":"https://www.ideals.illinois.edu/oai-pmh"},"display":{"title":"The influence of the interaction of fluoride (F) and aluminum (Al) on bioavailability in bacterial and mammalian systems","abstract":"Fluoride and aluminum, which are known to form a strong complex, are both present in finished drinking water. The effect of F and Al on one another's tissue accumulation was determined using adult, male New-Zealand white rabbits. Fluoride accumulation in plasma, urine, incisors and tibia was increased as the F addition to the drinking water increased within groups receiving a single concentration of Al. In contrast, F accumulation in plasma, urine, incisors and tibia decreased as the Al concentration increased within groups receiving a single F concentration. In addition, Al levels of plasma and tibia were significantly increased by the addition of F to the drinking water, even in animals receiving no Al in their drinking water. Therefore, some of the toxicity associated with high F level might in fact be associated with Al or a combined form of F and Al.","abstract_html":"Fluoride and aluminum, which are known to form a strong complex, are both present in finished drinking water. The effect of F and Al on one another's tissue accumulation was determined using adult, male New-Zealand white rabbits. Fluoride accumulation in plasma, urine, incisors and tibia was increased as the F addition to the drinking water increased within groups receiving a single concentration of Al. In contrast, F accumulation in plasma, urine, incisors and tibia decreased as the Al concentration increased within groups receiving a single F concentration. In addition, Al levels of plasma and tibia were significantly increased by the addition of F to the drinking water, even in animals receiving no Al in their drinking water. Therefore, some of the toxicity associated with high F level might in fact be associated with Al or a combined form of F and Al.","abstract_has_math":false,"creators":["Ahn, Hye-Won"],"institution":"University of Illinois at Urbana-Champaign","degree_name":"Ph.D.","degree_level":"Dissertation","degree_discipline":"Veterinary Biosciences","degree_department":null,"school":null,"contributors":["Jeffery, Elizabeth H."],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2011,"date_issued":"2011-05-07T12:53:59Z","date_published":"2011-05-07T12:53:59Z","updated_at":"2026-07-22T22:25:17Z","subjects":["Health Sciences, Toxicology","Health Sciences, Public Health","Environmental Sciences"],"languages":["eng"],"rights":["Copyright 1994 Ahn, Hye-Won"],"rights_urls":[],"identifier_entries":[{"key":"dc:identifier","label":"Identifier","values":["AAI9503125","(UMI)AAI9503125"],"render_values":[{"text":"AAI9503125","href":null,"code":true},{"text":"(UMI)AAI9503125","href":null,"code":true}]}]},"links":{"outbound_url":"http://hdl.handle.net/2142/20951","outbound_label":"Handle","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["Jeffery, Elizabeth H."]},{"key":"dc:creator","label":"Author","values":["Ahn, Hye-Won"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["2011-05-07T12:53:59Z","10000-01-01","1994"]},{"key":"dc:type","label":"Dc Type","values":["text"]},{"key":"thesis:degree_discipline","label":"Discipline","values":["Veterinary Biosciences"]},{"key":"thesis:degree_level","label":"Degree Level","values":["Dissertation"]},{"key":"thesis:degree_name","label":"Degree Name","values":["Ph.D."]},{"key":"thesis:institution_name","label":"Thesis Institution Name","values":["University of Illinois at Urbana-Champaign"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Health Sciences, Toxicology","Health Sciences, Public Health","Environmental Sciences"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["eng"]},{"key":"dc:rights","label":"Dc Rights","values":["Copyright 1994 Ahn, Hye-Won"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["AAI9503125","(UMI)AAI9503125","http://hdl.handle.net/2142/20951"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["Fluoride and aluminum, which are known to form a strong complex, are both present in finished drinking water. The effect of F and Al on one another's tissue accumulation was determined using adult, male New-Zealand white rabbits. Fluoride accumulation in plasma, urine, incisors and tibia was increased as the F addition to the drinking water increased within groups receiving a single concentration of Al. In contrast, F accumulation in plasma, urine, incisors and tibia decreased as the Al concentration increased within groups receiving a single F concentration. In addition, Al levels of plasma and tibia were significantly increased by the addition of F to the drinking water, even in animals receiving no Al in their drinking water. Therefore, some of the toxicity associated with high F level might in fact be associated with Al or a combined form of F and Al.","Because in vivo studies have shown that F causes the co-accumulation of Al in bone, we determined the interactive effect of these two agents on bone turnover and accumulation in mouse calvarial culture. The combination of F and Al increases alkaline phosphatase activity in calvaria. However, the co-accumulation of Al in bone treated with F that we reported using in an in vivo system could not be confirmed using a calvaria culture system, due to high non-specific adsorption of Al.","Further, the effect of Al on F uptake and mutagenicity in Salmonella typhymurium TA98 has been determined and any effect of Al on Ames test results for F was also determined. Intracellular F was below the limit of detection (0.2 ppm). However, F was taken up from media, providing that Al was also present. Neither F, Al, nor Al:F was found to be mutagenic as assessed by a modification of the Ames standard plate incorporation assay. While F did not appear to cause mutations in the presence or absence of Al, it was concluded that the mutagenicity test, using TA98, is not suitable for the evaluation of F mutagenicity.","Made available in DSpace on 2011-05-07T12:53:59Z (GMT). No. of bitstreams: 2 license.txt: 4922 bytes, checksum: 910b249b4beec47e7ab768910c8f966f (MD5) 9503125.pdf: 4416922 bytes, checksum: 295468f4f9e0ecc50aa6b646a1f8d8fd (MD5) Previous issue date: 1994","Item marked as restricted to the 'UIUC Users [automated]' Group (id=2) by Howard Ding (hding2@illinois.edu) on 2011-05-07T14:47:28Z Item is restricted indefinitely.","Restriction data tranferred 2014-07-01T11:21:26-05:00 Original Data Group with Access UIUC Users [automated] Release Date: none Reason: ETDs are only available to UIUC Users without author permission","ETDs are only available to UIUC Users without author permission","U of I Only"]},{"key":"dc:title","label":"Title","values":["The influence of the interaction of fluoride (F) and aluminum (Al) on bioavailability in bacterial and mammalian systems"]}]}],"canonical_facts":{"dc:contributor":["Jeffery, Elizabeth H."],"dc:creator":["Ahn, Hye-Won"],"dc:date":["2011-05-07T12:53:59Z","10000-01-01","1994"],"dc:description":["Fluoride and aluminum, which are known to form a strong complex, are both present in finished drinking water. The effect of F and Al on one another's tissue accumulation was determined using adult, male New-Zealand white rabbits. Fluoride accumulation in plasma, urine, incisors and tibia was increased as the F addition to the drinking water increased within groups receiving a single concentration of Al. In contrast, F accumulation in plasma, urine, incisors and tibia decreased as the Al concentration increased within groups receiving a single F concentration. In addition, Al levels of plasma and tibia were significantly increased by the addition of F to the drinking water, even in animals receiving no Al in their drinking water. Therefore, some of the toxicity associated with high F level might in fact be associated with Al or a combined form of F and Al.","Because in vivo studies have shown that F causes the co-accumulation of Al in bone, we determined the interactive effect of these two agents on bone turnover and accumulation in mouse calvarial culture. The combination of F and Al increases alkaline phosphatase activity in calvaria. However, the co-accumulation of Al in bone treated with F that we reported using in an in vivo system could not be confirmed using a calvaria culture system, due to high non-specific adsorption of Al.","Further, the effect of Al on F uptake and mutagenicity in Salmonella typhymurium TA98 has been determined and any effect of Al on Ames test results for F was also determined. Intracellular F was below the limit of detection (0.2 ppm). However, F was taken up from media, providing that Al was also present. Neither F, Al, nor Al:F was found to be mutagenic as assessed by a modification of the Ames standard plate incorporation assay. While F did not appear to cause mutations in the presence or absence of Al, it was concluded that the mutagenicity test, using TA98, is not suitable for the evaluation of F mutagenicity.","Made available in DSpace on 2011-05-07T12:53:59Z (GMT). No. of bitstreams: 2 license.txt: 4922 bytes, checksum: 910b249b4beec47e7ab768910c8f966f (MD5) 9503125.pdf: 4416922 bytes, checksum: 295468f4f9e0ecc50aa6b646a1f8d8fd (MD5) Previous issue date: 1994","Item marked as restricted to the 'UIUC Users [automated]' Group (id=2) by Howard Ding (hding2@illinois.edu) on 2011-05-07T14:47:28Z Item is restricted indefinitely.","Restriction data tranferred 2014-07-01T11:21:26-05:00 Original Data Group with Access UIUC Users [automated] Release Date: none Reason: ETDs are only available to UIUC Users without author permission","ETDs are only available to UIUC Users without author permission","U of I Only"],"dc:identifier":["AAI9503125","(UMI)AAI9503125","http://hdl.handle.net/2142/20951"],"dc:language":["eng"],"dc:rights":["Copyright 1994 Ahn, Hye-Won"],"dc:subject":["Health Sciences, Toxicology","Health Sciences, Public Health","Environmental Sciences"],"dc:title":["The influence of the interaction of fluoride (F) and aluminum (Al) on bioavailability in bacterial and mammalian systems"],"dc:type":["text"],"thesis:degree_discipline":["Veterinary Biosciences"],"thesis:degree_level":["Dissertation"],"thesis:degree_name":["Ph.D."],"thesis:institution_name":["University of Illinois at Urbana-Champaign"]},"updated_at":"2026-07-22T22:25:17Z"}